Tag: M.W:100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 25016-17-5

5-methyl-1- (pyrimidin-2-yl-methyl)lH-pyrazole-3-carboxylate (Scheme C-1)5-methyl -1H- pyrazole-3-carboxylate (4.60 g of the) in90mLN, N- dimethylformamideAmine solution and potassium carbonate (10.88g) and themixture is stirred at room temperature for 15 minutes.Then, 2- (chloromethyl) pyrimidine hydrochloride (6.49 gof), and the reaction mixture was heated at reflux18 hours, poured into 300mL water and extracted with ethylacetate. The organic phase was dried with sodium sulfate,Filtered and concentrated under reduced pressure. By columnchromatography on silica gel with cyclohexane / ethyl acetate (1: 9)The crude product was purified as eluent. 0.96g3- givemethyl-1- (pyrimidin-2-ylmethyl) lH-Pyrazole-5-carboxylate and 3.85g of the titlecompoun

According to the analysis of related databases, 25016-17-5, the application of this compound in the production field has become more and more popular.

Synthetic Route of 2075-45-8, These common heterocyclic compound, 2075-45-8, name is 4-Bromo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-{[2-(trimethylsilyl)ethoxy]methyl}-1H pyrazole-4-carbaldehyde was prepared as follows: To a solution of 4-bromo pyrazole (16.90 g, 115 mmol) in THF (400 mL) under N2 at 0 C was added NaH ( 3.31 g, 138 mmol) and stirred for 15 min. Neat SEM-Cl (21.10 g, 126.46 mmol) was added drop wise to the reaction mixture and stirred overnight at rt. The reaction was quenched with water (200 mL) and excess THF was removed in vacuo. The residue was extracted with EtOAc (2×500 mL), dried over MgS04 and removed in vacuo to give crude 4- bromo- 1 – ( [2-(trimethylsilyl)ethoxy]methyl) – lH-pyrazole (36 g) as a yellow oil. The crude material was used in next step without further purification. To a solution of 4-bromo-l-{[2-(trimethylsilyl)ethoxy]methyl}-IH-pyrazole (35.83 g, 129.35 mmol) in THF (750 mL) at at -78 C under N2 was added n-BuLi (67.26 mL, 168.16 mmol, 2.5 M) slowly. After the reaction mixture was stirred for 3 h at -78 C, DMF (50 mL) was added at -78 C and warmed to rt overnight. It was cooled to -30 C, quenched with 1 N HCl (120 mL) and stirred at 0 C for 30 min and 30 min at rt. The extraction was carried out with EtOAc (2×500 mL) and washed with brine (2×150 mL). The combined organic layers were dried over MgS04, filtered and removed in vacuo. The crude material was purified on silica gel and eluted with EtOAc/hexanes (from 5% to 20%) to yield 1-{[2- (trimethylsilyl)ethoxy]methyl]-1H pyrazole-4-carbaldehyde (12.34 g, 34%) as brown oil

The synthetic route of 2075-45-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Quality Control of Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate

A mixture of 2-[2-(3-chloro-5-fluorobenzyl)-1-benzothiophen-7-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.50 g, 3.72 mmol), ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate (0.76 g, 4.5 mmol) and copper(II) acetate monohydrate (0.37 g, 1.9 mmol) in pyridine (8 mL) was reacted for 20 hr at 50C. The reaction solution was concentrated, and the residue was diluted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate-hexane 1:10) to give ethyl 1-[2-(3-chloro-5-fluorobenzyl)-1-benzothiophen-7-yl]-3,5-dimethyl-1H-pyrazole-4-carboxylate (0.88 g). To a solution of the compound in methanol (20 mL) was added 1N aqueous sodium hydroxide solution (12 mL, 12 mmol) at room temperature, and the mixture was stirred for 1 days at 60C. To the reaction mixture were added water and hydrochloric acid, and the aqueous layer was acidified. The mixture was extracted with ethyl acetate. The organic layer was dried over magnesium sulfate, and evaporated under reduced pressure. The obtained residue was crystallized from ether to give the title compound (630 mg, yield 41%). melting point 187 – 188C. 1H-NMR (DMSO-d6)delta: 2.38 (6 H, s), 4.29 (2 H, s), 7.18 – 7.25 (1 H, m), 7.30 (1 H, s), 7.36 – 7.44 (2 H, m), 7.46 – 7.54 (1 H, m), 7.72 – 7.81 (1 H, m), 7.88 – 7.92 (1 H, m), 12.43 (1 H, br s).

The synthetic route of 35691-93-1 has been constantly updated, and we look forward to future research findings.

Reference of 23170-45-8,Some common heterocyclic compound, 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N2 protection,3-methyl-1H-pyrazole-4-carboxylate(0.14 g, 1.0 mmol), CuI (19.1 mg,0.1 mmol), K2CO3 (0.29 g, 2.1 mmol)III3 (0.34 g, 1.2 mmol),(E) -N, N’-dimethyl-1,2-cyclohexyl diamine (28.5 mg, 0.2 mmol) and DMF (3 mL) were added to a 25 mL two-necked flask and reacted at 110 C for 24 h,Cooled to room temperature, diluted with 10 mL of water, extracted with ethyl acetate (15 mL x 3)Saturated brine (10 mL), dried over anhydrous magnesium sulfate, the solvent was removed by distillation under reduced pressure,Silica gel column (V ethyl acetate: V petroleum ether = 6: 1),To a solution of 0.2 g of methyl orange 1- (3′-nitro-4′-piperidine-phenyl) -3-methyl-pyrazole-4-carboxylate (IV3).

The synthetic route of 23170-45-8 has been constantly updated, and we look forward to future research findings.

Related Products of 1780-72-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1780-72-9 as follows.

To a solution of 22 (14.0 g, 79.54 mmol) in ethanol (280 mL) were added ethyl acetoacetate (15.15 mL, 15.59 g, 119.79 mmol) and acetic acid (4.55 mL, 79.54 mmol) at room temperature under nitrogen atmosphere. The reaction mixture was then heated to 85 C. and stirred for 16 h. The progress of the reaction was monitored by TLC. After 16 h, the reaction mixture was concentrated completely under reduced pressure. The resultant solid was treated with CH2Cl2 (30 mL) and the solid was filtered. The filtered solid was dried under high vacuum at 45-55 C. to afford 23 (10.7 g, 55.57%) as a pale yellow solid.

According to the analysis of related databases, 1780-72-9, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 133228-21-4

17(1) 1-(Dimethylsulfamoyl)-5-(2-chloro-6-methylphenylthio)pyrazole 32.3 ml of a 1.59M solution of butyllithium in hexane were added, at -78 C. and under an atmosphere of nitrogen, to a solution of 8.18 g of 1-(dimethylsulfamoyl)pyrazole [prepared as described in Example 1(1)] in 250 ml of dry tetrahydrofuran, and the resulting mixture was allowed to stand at the same temperature for 40 minutes. At the end of this time, a solution of 14.73 g of 2-chloro-6-methylphenyl disulfide in 100 ml of tetrahydrofuran was added to the mixture, which was then stirred at the same temperature for 1 hour. The reaction mixture was then mixed with an aqueous solution of ammonium chloride and extracted with ethyl acetate. The extract was washed with water and dried over anhydrous sodium sulfate, after which it was concentrated by evaporation under reduced pressure. The concentrate was purified by column chromatography through silica gel, eluted with a 10:1 by volume mixture of hexane and ethyl acetate, to give 13.70 g (yield 88%) of the title compound as an oil. Nuclear Magnetic Resonance Spectrum (CDCl3, 200 MHz), delta ppm: 7.48 (1H, doublet, J=1.6 Hz); 7.45-7.27 (3H, multiplet); 5.32 (1H, doublet, J=1.6 Hz); 3.05 (6H, singlet); 2.53 (3H, singlet).

The synthetic route of N,N-Dimethyl-1H-pyrazole-1-sulfonamide has been constantly updated, and we look forward to future research findings.

3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 1H-Pyrazole-3,5-dicarboxylic acid

Example 20: 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrazole-3-carboxylic acid methyl ester(i) 1H-Pyrazole-3,5-dicarboxylic acid dimethyl ester To 12 g of 1H-Pyrazole-3,5-dicarboxylic acid 100 ml HCl in methanol (8M) were added at RT and stirred for 48h. Then the solvents were removed under reduced pressure and the residue codestilled with toluene (2X50 ml). Yield: 14g.

The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.

Electric Literature of 57999-06-1,Some common heterocyclic compound, 57999-06-1, name is 4-Phenyl-1H-pyrazol-5-amine, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A suspension of 3(5)-amino-4-(thien-2-yl)pyrazole (1h) or 3(5)-amino-4-phenylpyrazole (1i) 11,13 (10 mmoles) and ethyl 2-(pyrazol-10-yl)-2-formylacetate (A) or ethyl 2-(imidazol-10-yl)-2-formylacetate (B) (10 mmoles) in dyglime (20 mL) was refluxed under magnetic stirring until the starting material disappeared. The precipitate was collected by filtration from the reaction mixture and recrystallized by suitable solvent, obtaining compounds 5a, 5b, 6a and 6b respectively.

The synthetic route of 57999-06-1 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole

To a solution of oxetan-3-ol (0.273 mL, 4.14 mmol) in dry DMF (5 mL) was added sodium hydride (60% in mineral oil, 265.5 mg, 5.53 mmol), and the mixture was stirred at r.t. for about 1 h. 5-(Chloromethyl)-l,3-dimethyl-lH-pyrazole (400 mg, 2.76 mmol) in DMF (5 mL) was added and the reaction mixture was stirred for 16 h at r.t. After removal of DMF under vacuum, the residue was dissolved in DCM (50 mL) and water (20 mL). The aqueous layer was extracted with DCM and the combined organic extracts were washed with brine, then dried over Na2S04 and evaporated to dryness. The crude residue was purified by column chromatography, with a gradient of 25-100%) EtOAc in heptane, to afford the title compound (349 mg, 69%). Method B HPLC-MS: MH+ mlz 183, RT 1.09 minutes (100%)

According to the analysis of related databases, 852227-86-2, the application of this compound in the production field has become more and more popular.

Electric Literature of 33064-36-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33064-36-7, name is 1H-Pyrazole-3-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A flask was charged with t-butyl lH-pyrazole-3-carboxylate (2.42 g, 14.4 mmol, 1.00 equiv), DCM (20 mL), 4-nitrophenyl chloroformate (2.90 g, 14.4 mmol, 1.00 equiv), and triethylamine (4.36 g, 43. 1 mmol, 3.00 equiv). The resulting solution was stirred for 3 h at room temperature and concentrated under reduced pressure to provide 4.80 g (crude) of 3-(t-butyl) l-(4- nitrophenyl) lH-pyrazole-l,3-dicarboxylate as a yellow oil. LCMS (ESI, m/z): 334 [M+H]+.

The synthetic route of 1H-Pyrazole-3-carboxamide has been constantly updated, and we look forward to future research findings.