Category: 1780-72-9

These common heterocyclic compound, 1780-72-9, name is 4-Bromo-5-methyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4-Bromo-5-methyl-1H-pyrazol-3-amine

To a solution of 2H-pyrazol-3-ylamine (2.3 mmol, 1 eq) in acetic acid (3 mL) was added 2-ethoxymethylene-malonic acid diethyl ester (500 muL, 2.5 mmol, 1.1 eq). The mixture was heated at 120 C. for 20 h in a sealed tube. After cooling, the precipitate was filtered and washed with ethanol to afford the expected compound (from 30% to 80% yield). [0595] The expected compound was obtained according to general procedure C step 1 using 4-bromo-5-methyl-2H-pyrazol-3-ylamine. The expected compound was isolated as pale yellow powder. [0596] MS: 300.0 [0597] Mp: decomposes at 270 C.-275 C.

The synthetic route of 4-Bromo-5-methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; European Molecular Biology Laboratory; F. Hoffmann-La Roche AG; WOLKERSTORFER, Andrea; SZOLAR, Oliver; HANDLER, Norbert; CUSACK, Stephen; SAUVAITRE, Thibault; SIMON, Celine; MORICE, Christophe; GIETHLEN, Bruno; LANGER, Thierry; SMITH, Mark; SO, Sung-Sau; CLASSEN-HOUBEN, Dirk; BUSCHMANN, Helmut; US2013/317022; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1780-72-9, name is 4-Bromo-5-methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., name: 4-Bromo-5-methyl-1H-pyrazol-3-amine

General procedure: The kinetics of reactions were followed by measuring the change in absorbance at suitable wavelengthsas a function of time. Working wavelengths were determined for each reaction system, recording thespectra of reaction mixture over wavelength range between 220 and 600 nm. Substitution reactionswere studied under pseudo-first-order conditions whereas the concentration of entering ligand wasalways in large excess (at least 10-fold). Reactions were initiated by mixing equal volumes (1.5 cm3) ofcomplex (2 × 10-4 M) and ligand (2 × 10-3; 4 × 10-3; 6 × 10-3; 8 × 10-3; 1 × 10-2 M) solutions in a quartzcuvette. The changes in absorbance versus time were fitted as a single-exponential function usingOrigin Pro 8. Values for the pseudo-first-order rate constants, kobsd, were calculated as the average valuefrom three to five independent kinetic runs. Experimental data are reported in tables S2-S13 (supplementarymaterial). The values of pseudo-first-order rate constants, kobsd, at 298 K were recalculatedby Guggenheim and Kezdy-Swinbourne methods (table 14S) [33, 34]. All reactions were studied atfour different temperatures (288, 298, 308, and 313 K). The activation parameters, DeltaH? and DeltaS?, werecalculated using the Eyring equation. Eyring plots for all studied systems are given in supplementarymaterial, figures 4S-15S.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kosovi?, Milica; Jovanovi?, Sne?ana; Bogdanovi?, Goran A.; Giester, Gerald; Ja?imovi?, ?eljko; Bugar?i?, ?ivadin D.; Petrovi?, Biljana; Journal of Coordination Chemistry; vol. 69; 19; (2016); p. 2819 – 2831;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 1780-72-9, These common heterocyclic compound, 1780-72-9, name is 4-Bromo-5-methyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The kinetics of reactions were followed by measuring the change in absorbance at suitable wavelengthsas a function of time. Working wavelengths were determined for each reaction system, recording thespectra of reaction mixture over wavelength range between 220 and 600 nm. Substitution reactionswere studied under pseudo-first-order conditions whereas the concentration of entering ligand wasalways in large excess (at least 10-fold). Reactions were initiated by mixing equal volumes (1.5 cm3) ofcomplex (2 × 10-4 M) and ligand (2 × 10-3; 4 × 10-3; 6 × 10-3; 8 × 10-3; 1 × 10-2 M) solutions in a quartzcuvette. The changes in absorbance versus time were fitted as a single-exponential function usingOrigin Pro 8. Values for the pseudo-first-order rate constants, kobsd, were calculated as the average valuefrom three to five independent kinetic runs. Experimental data are reported in tables S2-S13 (supplementarymaterial). The values of pseudo-first-order rate constants, kobsd, at 298 K were recalculatedby Guggenheim and Kezdy-Swinbourne methods (table 14S) [33, 34]. All reactions were studied atfour different temperatures (288, 298, 308, and 313 K). The activation parameters, DeltaH? and DeltaS?, werecalculated using the Eyring equation. Eyring plots for all studied systems are given in supplementarymaterial, figures 4S-15S.

Statistics shows that 4-Bromo-5-methyl-1H-pyrazol-3-amine is playing an increasingly important role. we look forward to future research findings about 1780-72-9.

Reference:
Article; Kosovi?, Milica; Jovanovi?, Sne?ana; Bogdanovi?, Goran A.; Giester, Gerald; Ja?imovi?, ?eljko; Bugar?i?, ?ivadin D.; Petrovi?, Biljana; Journal of Coordination Chemistry; vol. 69; 19; (2016); p. 2819 – 2831;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1780-72-9, name is 4-Bromo-5-methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Computed Properties of C4H6BrN3

General procedure: Kinetics of reactions were followed using stopped-flow technique by measuring the change in absorbance as a function of time at suitable wavelengths. The working wavelengths were determined by comparing consecutive spectra of the reaction mixture over the wavelength range 200-600 nm. The reactions were studied under the pseudo-first-order conditions, which means that the concentration of entering ligand was always much higher (at least a 10-fold times) than the concentration of complex ([complex]e = 1 * 10-4 M, [ligand]e = from1 * 10-3 M to 5 * 10-3 M). Reactions were initiated in the stopped-flow instrument by mixing equal volumes of complex solution and entering ligand solution. Reactions were followed for at least eight half-lives. Kinetic traces were fitted as a double-exponential function. The pseudo-first-order rate constants, kobsd1 and kobsd2,were obtained as average values from four to eight independent kinetic runs. All reactions were studied at three different temperatures (from 15 to 35 C) to determine the activation parameters.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kosovi?, Milica; Ja?imovi?, ?eljko; Bugar?i?, ?ivadin D.; Petrovi?, Biljana V.; Transition Metal Chemistry; vol. 41; 2; (2016); p. 161 – 168;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 1780-72-9, name is 4-Bromo-5-methyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C4H6BrN3

To a solution of 2H-pyrazol-3-ylamine (2.3 mmol, 1 eq) in acetic acid (3 mL) was added 2-ethoxymethylene-malonic acid diethyl ester (500 muL, 2.5 mmol, 1.1 eq). The mixture was heated at 120 C. for 20 h in a sealed tube. After cooling, the precipitate was filtered and washed with ethanol to afford the expected compound (from 30% to 80% yield). [0595] The expected compound was obtained according to general procedure C step 1 using 4-bromo-5-methyl-2H-pyrazol-3-ylamine. The expected compound was isolated as pale yellow powder. [0596] MS: 300.0 [0597] Mp: decomposes at 270 C.-275 C.

The synthetic route of 4-Bromo-5-methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; European Molecular Biology Laboratory; F. Hoffmann-La Roche AG; WOLKERSTORFER, Andrea; SZOLAR, Oliver; HANDLER, Norbert; CUSACK, Stephen; SAUVAITRE, Thibault; SIMON, Celine; MORICE, Christophe; GIETHLEN, Bruno; LANGER, Thierry; SMITH, Mark; SO, Sung-Sau; CLASSEN-HOUBEN, Dirk; BUSCHMANN, Helmut; US2013/317022; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 1780-72-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1780-72-9 as follows.

To a solution of 22 (14.0 g, 79.54 mmol) in ethanol (280 mL) were added ethyl acetoacetate (15.15 mL, 15.59 g, 119.79 mmol) and acetic acid (4.55 mL, 79.54 mmol) at room temperature under nitrogen atmosphere. The reaction mixture was then heated to 85 C. and stirred for 16 h. The progress of the reaction was monitored by TLC. After 16 h, the reaction mixture was concentrated completely under reduced pressure. The resultant solid was treated with CH2Cl2 (30 mL) and the solid was filtered. The filtered solid was dried under high vacuum at 45-55 C. to afford 23 (10.7 g, 55.57%) as a pale yellow solid.

According to the analysis of related databases, 1780-72-9, the application of this compound in the production field has become more and more popular.

Reference of 1780-72-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1780-72-9 name is 4-Bromo-5-methyl-1H-pyrazol-3-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[Pt(bpma)(pzBr)]Cl2·2H2O was synthesized with reaction of the methanolic solution of pzBr (0.0022 g,12.4 muM, 4 cm3) and aqueous solution of [Pt(bpma)Cl]Cl (0.006 g, 12.4 muM, 5 cm3) mixed in molar ratio1 : 1. pH of the colorless solution was maintained at 7 because [Pt(bpma)Cl]Cl could be converted intothe unreactive hydroxo species at higher pH. The mixture was stirred for 24 h and after two days the colorless crystal product was filtered off and washed with methanol. The crystals of the complex aremechanically separated for X-ray analysis. Anal Calcd for C16H23Cl2BrN6O2Pt (%) FW = 677.28: C, 28.37; H,3.42; N, 12.41. Found: C, 28.29; H, 3.48; N, 12.10; UV-vis: lambdamax (nm) = 245; 271, 1H NMR, 200 MHz, D2O: delta(ppm): 1.89 (s, 3H, CH3-pzBr); 3.76 (s, 4H, CH2-bpma); 7.42 (t, 2H, J = 6.8 Hz, H4-bpma); 7.68 (d, 2H, J = 8 Hz,H3-bpma); 7.74 (d, 2H, J = 6.8 Hz, H6-bpma), 8.18 (t, 2H, J = 8 Hz, H5-bpma). IR (KBr, 4000-300 cm-1):3500-3200 (N-H stretch, O-H stretch); 3150-2850 (-CH stretch,=CH stretch); 1630 (C=N stretch); 787(N-H wagging) (figures 1S-3S, supplementary material).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-5-methyl-1H-pyrazol-3-amine, and friends who are interested can also refer to it.

Electric Literature of 1780-72-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1780-72-9 as follows.

General procedure: To a mixture of 1-aryl-3-ethoxy-2-(phenylsulfonyl)prop-2-en-1-one 3refPreviewPlaceHolder[28] (10 mmol) and appropriate aminopyrazole derivative 2 (10 mmol) in absolute EtOH (25 mL) were added few drops of piperidine and the reaction mixture was refluxed for 1 h, then left to cool. The formed solid product was filtered off, washed with ethanol and recrystallized from EtOH/DMF to afford products identical in all respects (mp, mixed mp and spectra) with those obtained by refPreviewPlaceHolderMethod A above.

According to the analysis of related databases, 1780-72-9, the application of this compound in the production field has become more and more popular.