Electric Literature of 57999-06-1,Some common heterocyclic compound, 57999-06-1, name is 4-Phenyl-1H-pyrazol-5-amine, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A suspension of 3(5)-amino-4-(thien-2-yl)pyrazole (1h) or 3(5)-amino-4-phenylpyrazole (1i) 11,13 (10 mmoles) and ethyl 2-(pyrazol-10-yl)-2-formylacetate (A) or ethyl 2-(imidazol-10-yl)-2-formylacetate (B) (10 mmoles) in dyglime (20 mL) was refluxed under magnetic stirring until the starting material disappeared. The precipitate was collected by filtration from the reaction mixture and recrystallized by suitable solvent, obtaining compounds 5a, 5b, 6a and 6b respectively.
The synthetic route of 57999-06-1 has been constantly updated, and we look forward to future research findings.