Category: 25016-17-5

Some common heterocyclic compound, 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 25016-17-5

General procedure: A mixture of 1 (5.68 mmol) and potassium tert-butoxide (7.59 mmol) in 80 ml of anhydrous THF was heated under reflux for 1 h. After cooling to 0 C, a solution of ethylbromoacetate (7.78 mmol) in 20 ml of THF was slowly added. The reaction mixture was then stirred for 5 h at room temperature. The resulting mixture was filtered and the solvent was evaporated to dryness. The obtained residue was purified on alumina using dichloromethane as eluant.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 25016-17-5, its application will become more common.

Reference:
Article; Radi, Smaail; Yahyi, Abderrahmane; Ettouhami, Abdelkader; Chaudhary Jha, Ambika; Adarsh; Robeyns, Koen; Garcia, Yann; Polyhedron; vol. 85; (2015); p. 383 – 388;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: pyrazoles-derivatives

b. Synthesis of I.S-dimethyl-pyrazole-delta-carboxylic acid methylester; S-methyl-pyrazole-delta-carboxylic acid methyl ester (6.8 Kg Kg) is dissolved in DMF (8L) and dimethyl sulfate (6.0 L) is added dropwise in over three hours. The reaction is exothermic and the addition of dimethyl sulfate must be controlled so that the internal temperature does not exceed 900C. After complete addition, the mixture is heated for 18 hours at 800C. The mixture is then cooled to room temperature, diluted with ice (3.4 Kg), and cooled in an ice bath. A solution of aqueous 28% ammonium hydroxide (8.6 L) is added to the reaction mixture over 3 hours. The resulting mixture is stirred for 18 hours, diluted with ethyl acetate (12 L) and water (16 L), extracted, and the layers are separated. The organic layer is washed with water (4L), dried over MgSO4, filtered, and concentrated under reduced pressure to provide 5.14 Kg of 1 ,3-dimethyl-pyrazole-delta-carboxylic acid methylester (69 % yield with a purity of >90 % by HPLC). The crude product is used directly in the next step.

The synthetic route of 25016-17-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; WO2006/48761; (2006); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C6H8N2O2

General procedure: A mixture of 1 (5.68 mmol) and potassium tert-butoxide (7.59 mmol) in 80 ml of anhydrous THF was heated under reflux for 1 h. After cooling to 0 C, a solution of ethylbromoacetate (7.78 mmol) in 20 ml of THF was slowly added. The reaction mixture was then stirred for 5 h at room temperature. The resulting mixture was filtered and the solvent was evaporated to dryness. The obtained residue was purified on alumina using dichloromethane as eluant.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 25016-17-5, its application will become more common.

Reference:
Article; Radi, Smaail; Yahyi, Abderrahmane; Ettouhami, Abdelkader; Chaudhary Jha, Ambika; Adarsh; Robeyns, Koen; Garcia, Yann; Polyhedron; vol. 85; (2015); p. 383 – 388;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 25016-17-5

5-methyl-1- (pyrimidin-2-yl-methyl)lH-pyrazole-3-carboxylate (Scheme C-1)5-methyl -1H- pyrazole-3-carboxylate (4.60 g of the) in90mLN, N- dimethylformamideAmine solution and potassium carbonate (10.88g) and themixture is stirred at room temperature for 15 minutes.Then, 2- (chloromethyl) pyrimidine hydrochloride (6.49 gof), and the reaction mixture was heated at reflux18 hours, poured into 300mL water and extracted with ethylacetate. The organic phase was dried with sodium sulfate,Filtered and concentrated under reduced pressure. By columnchromatography on silica gel with cyclohexane / ethyl acetate (1: 9)The crude product was purified as eluent. 0.96g3- givemethyl-1- (pyrimidin-2-ylmethyl) lH-Pyrazole-5-carboxylate and 3.85g of the titlecompoun

According to the analysis of related databases, 25016-17-5, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Safety of Methyl 5-methyl-1H-pyrazole-3-carboxylate

Methyl 5-methylpyrazole-3-carboxylate (14 g, 0.1 mol), ethyl bromide (10.9 g, 0.1 mol),Tetrabutylammonium hydrogen sulfate (2.7 g, 0.008 mol), dissolved in 10 ml of dimethyl sulfoxide (DMSO),Potassium hydroxide solution was added dropwise [potassium hydroxide solution: a solution obtained by dissolving 22.4 g (0.40 mol) of potassium hydroxide in 20 ml of water],The reaction is exothermic, the addition is completed, and the mixture is stirred at room temperature overnight, diluted with water and quenched to adjust the pH to 2 to precipitate a white solid.Nuclear magnetic resonance test is a mixture of 1-ethyl-3-methylpyrazole-5-carboxylic acid and 1-ethyl-5-methylpyrazole-3-carboxylic acid.The ratio is 1:1, and the total weight of the product after drying is 14.6 g, and the yield is 94.8percent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 25016-17-5, These common heterocyclic compound, 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 1.2 g of a mixture of acids 8 and 9 obtained in the previous synthesis 5 mL of acetic anhydride was added, the mixture was stirred for 4 hours at boiling and left overnight. The precipitated crystals in the form of fine colorless needles were filtered off and washed with acetic acid. Yield 452 mg (41%), mp 144-145C. The acetic anhydride contained in the mother liquor was hydrolyzed with water. The precipitated crystals were filtered off, washed with water and after drying recrystallized from methanol. Additionally, 101 mg of the reaction product were obtained, total yield 50%. IR spectrum, nu, cm-1: 1730(CO), 1630 (Ph). 1H NMR spectrum, delta, ppm: 2.41 s(3H, CH3), 6.97 s (1H, CH), 7.41 t (1H, Ph, J 7.2 Hz),7.45 t (2H, Ph, J 7.2 Hz), 7.82 d (2H, Ph, J 7.6 Hz),8.50 s (1H,CH). 13 NMR spectrum, delta, ppm: 15.3(CH3), 109.1 (CH), 109.5 (CH), 126.1 (Ph), 128.8,130.6 (Ph), 131.2 (Ph), 131.7 (Ph), 143.6, 152.9, 154.8(CO). Found, %: C 64.98; H 4.48; N 12.40.13H10N2O2. Calculated, %: C 65.02; H 4.46; N 12.38.

Statistics shows that Methyl 5-methyl-1H-pyrazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 25016-17-5.

Application of 25016-17-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

b) Method for svnthesising the pyrazolecarboxylic acid ED-2b (synthesis method B)ED-5a (2.00 g, 14.3 mmol) in DMF (7 mL) is added dropwise to a suspension of NaH (694 mg, 60 %, 17.4 mmol) in anhydrous DMF (8 mL) while cooling with ice and the mixture is slowly thawed to RT over 1 h. Then isopropyl bromide (2.7 mL, 28.8 mmol) is added and the mixture is stirred for 20 h at RT. The reaction mixture is mixed with a little water, then for saponification aqueous LiOH solution (414 mg in 3 mL H20) is added and the mixture is stirred for 2 h at 40C. The reaction mixture is neutralised with hydrochloric acid, evaporated down to some extent using the rotary evaporator and the residue is purified by preparative RP-MPLC. The product-containing fractions of ED-2b (HPLC-MS: tRet. = 0.00 min; MS (M-H)” = 167) are combined and freeze-dried.

The chemical industry reduces the impact on the environment during synthesis Methyl 5-methyl-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.