Reference of 23170-45-8,Some common heterocyclic compound, 23170-45-8, name is Methyl 3-methyl-1H-pyrazole-4-carboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N2 protection,3-methyl-1H-pyrazole-4-carboxylate(0.14 g, 1.0 mmol), CuI (19.1 mg,0.1 mmol), K2CO3 (0.29 g, 2.1 mmol)III3 (0.34 g, 1.2 mmol),(E) -N, N’-dimethyl-1,2-cyclohexyl diamine (28.5 mg, 0.2 mmol) and DMF (3 mL) were added to a 25 mL two-necked flask and reacted at 110 C for 24 h,Cooled to room temperature, diluted with 10 mL of water, extracted with ethyl acetate (15 mL x 3)Saturated brine (10 mL), dried over anhydrous magnesium sulfate, the solvent was removed by distillation under reduced pressure,Silica gel column (V ethyl acetate: V petroleum ether = 6: 1),To a solution of 0.2 g of methyl orange 1- (3′-nitro-4′-piperidine-phenyl) -3-methyl-pyrazole-4-carboxylate (IV3).
The synthetic route of 23170-45-8 has been constantly updated, and we look forward to future research findings.