Category: 127107-23-7

Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127107-23-7, Safety of 1-Methyl-1H-pyrazol-4-amine hydrochloride

2-((6-((2,5-dichloropyrimidin-4-yl)amino)hexahydrofuro[3,2-b]furan-3-yl)oxy)ethanol (0.18 g, 0.54 mmol) was suspended in n-BuOH (5 mL) and 1-methylpyrazol-4-amine hydrochloride (0.15 g, 1.10 mmol) and N,N-diisopropylethylamine (0.28 g, 2.18 mmol) were added thereto. The mixture was placed in a sealed tube and then heated to 150 C with stirring overnight and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (DCM / MeOH (v / v) = 20/1). The title compound was obtained as a brown viscous liquid (42 mg, 20%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Li Xiaobo; Dai Weilong; Wang Tingjin; (74 pag.)CN104926824; (2017); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 127107-23-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.

A 25 mL round-bottom flask was charged with intermediate 46.3 (462 mg, 1.17 mmol, 1.00 equiv), n-BuOH (5 mL), 1-methyl-1H-pyrazol-4- amine hydrochloride (187 mg, 1.40 mmol, 1.20 equiv) and HC1 in 1,4-dioxane (0.5 ml). The reaction was stirred for 16 hours at 110 C in an oil bath. The resulting mixture was concentrated under vacuum and diluted with 0.5 mL of sodium carbonate (1 mol/L). To this mixture was added 1 mL of methanol, and the resulting solution was extracted with 3 x 20 mL of CHC13/1PA3: 1. The organic layers were combined and dried over anhydrous sodium sulfate and concentrated under vacuum. The crude product was purified using preparative HPLC to furnish 45.7 mg (9%) of compound 1-47 as a white solid. LCMS (ES, m/z): 457 [M+H], ?H NMR (300 MHz ,CD3OD): oe 7.869 (1H, s), 7.564 (1H, s), 4.8684.597 (1H, s), 4.0454.054 (1H, s), 3.888 (3H, s) 3.736 (4H, t), 2.5592.658 (4H, s), 2.2062.423 (3H, s), 2.0412.103 (2H, m), 1.3111.534 (1OH, m).

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-4-amine hydrochloride. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine; WO2015/48281; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, A new synthetic method of this compound is introduced below., name: 1-Methyl-1H-pyrazol-4-amine hydrochloride

The 2,5-dichloro-N-(6-methoxyhexahydrofuro[3,2-b]furan-3-yl)pyrimidin-4-amine (430mg, 1.4046 mmol), diisopropylethylamine (546.7 mg, 4.23 mmol) and 1-methylpyrazol-4-amine hydrochloride (283.3 mg,2.12 mmol) was dissolved in n-BuOH (10 mL), the temperature of the reaction solution was raised to 150 C, sealed tube reaction for 23 hours, and then concentrated under reduced pressure.The residue was purified by silica gel column chromatography (DCM / MeOH (v / v) = 50/1) to afford the title compound as a white solid which was recrystallized from acetone to give the title compound as a white solid (220 mg, 42.6% ).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Li Xiaobo; Dai Weilong; Wang Tingjin; (74 pag.)CN104926824; (2017); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127107-23-7, Computed Properties of C4H8ClN3

. Into a 2000-mL 3-necked round-bottom flask, were placed a solution of intermediate 24.3 (56 g, 152.22 mmol, 1.00 equiv) in n-butanol (1000 mL) and 1- methyl-1H-pyrazol-4-amine hydrochloride (40.89 g, 306.11 mmol, 2.01 equiv). The reaction was stirred overnight at 110 C in an oil bath. Upon completion, the reaction was cooled to room temperature solids were collected by filtration and the resulting solution was diluted with 500 mL of H20. The pH value of the solution was adjusted to 10 with sodium hydroxide (1 mol/L). The resulting solids were collected by filtration and dried in an oven under reduced pressure to furnish 61.9 g (95%) of compound 1-24 as an off-white solid. LCMS: (ES, m/z):429 [M+H] ?HNMR: (400MHz, CD3OD): ?5 7.877(1H, s), 7.568(1H, s), 4.044(1H, s), 3.887(3H, s), 3.751- 3.740(4H, d), 2.692-.2638(7H, m), 2.343(1H, s), 2.264(2H, s), 2.099(2H, s), 1.514-1.392(4H, m).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine; WO2015/48281; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of 127107-23-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 127107-23-7 name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-bromo-N-(l-hydroxy-2-methylpropan-2-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)- 5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (150 mg, 338 muiotaetaomicron), l-methyl-lH-pyrazol-4-amine hydrochloride (67.8 mg, 526 muiotaetaomicron), BINAP (10.5 mg, 16.9 muiotaetaomicron), palladium (II) acetate (19.0 mg, 84.6 muiotaetaomicron) and sodium iert-butoxide (81.3 mg, 846 muiotaetaomicron) in DMF (1 mL) and toluene (500 munu> was heated in a microwave at 140C for 20 min. The reaction mixture was diluted with water then extracted into ethyl acetate (3x). The combined organic extracts were washed with brine then dried over magnesium sulfate. Purification by chromatography (silica, 20-65 % of a 10:89.5:0.5 methanol :dichloromethane: ammonium hydroxide solution in dichloromethane) gave N-(l-hydroxy-2-methylpropan-2-yl)-2-(l -methyl- lH-pyrazol-4-ylamino)-5-((2- (trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (28 mg, 60.9 muiotaetaomicron, 18 %) as a light yellow solid. (EI/CI) m/r. 460.3 [M + H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazol-4-amine hydrochloride, and friends who are interested can also refer to it.

Electric Literature of 127107-23-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 127107-23-7 name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Into a 20 mL round-bottom flask under nitrogen, were placed intermediate 50.3 (83 mg, 0.21 mmol, 1.00 equiv), butan-1-ol (2 mL) and 1-methyl-1H- pyrazol-4-amine hydrochloride (32 mg, 0.39 mmol, 1.20 equiv). The reaction was stirred overnight at 110 C in an oil bath, then concentrated under vacuum. The resulting solution was diluted with 0.5 mL of sodium bicarbonate and concentrated under vacuum. The resulting solution was extracted with DCM/IPA (3/1), and the organic layers were combined and concentrated under vacuum. The crude product was purified using flash column chromatography to furnish 11.4mg (12%) of compound I-SO as a brown solid. LCMS; (ES, m/z): 471 [M+H] ?H NMR (400 MHz, CD3OD): oe 7.828 (s, 1H), 7.526 (s, 1H), 3.842 (s, 3H), 3.6793.710 (m, 4H), 2.5962.626 (m, 4H), 2.216 (s, 3H), 2.0672.082 (d, 2H), 1.3951.460 (m, 13H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazol-4-amine hydrochloride, and friends who are interested can also refer to it.

Synthetic Route of 127107-23-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Into a 25 mL round-bottom flask were placed intermediate 48.3 (330 mg, 0.84 mmol, 1.00 equiv), n-BuOH (10 mL) and 1-methyl-1H-pyrazol- 4-amine hydrochloride (170 mg, 1.27 mmol, 1.20 equiv). The reaction was stirred overnight at110 C in an oil bath. The resulting mixture was concentrated under vacuum, diluted with sodium carbonate (1 mol/L) and extracted with 3 x 20 mL of DCE/IPA (3:1). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under vacuum. The crude product was purified by preparative HPLC to furnish 81.7 mg (21%) of compound 1-49 as an off-white solid. LCMS: 455 [M+H] ?H NMR: (300MHz, CD3OD): oe 7.518-7.817 (2H, s), 3.998 (1H, s), 3.836 (1H, d), 3.888 (4H, s), 3.5083.781 (4H, t), 2.6062.636 (4H, t), 2.2062.321 (6H, m), 1.1741.490 (8H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazol-4-amine hydrochloride, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127107-23-7, Application In Synthesis of 1-Methyl-1H-pyrazol-4-amine hydrochloride

Synthesis of Compound 1-8. Into a 25-mL round-bottom flask, was placed 8.5 (50 mg, 0.15 mmol, 1.00 equiv), l-methyl-lH-pyrazol-4-amine hydrochloride (30 mg, 0.22 mmol, 1.50 equiv), K3P04 (99 mg, 0.45 mmol, 3.00 equiv), Xphos-Pd (13 mg, 0.10 equiv) in tert-butanol (5 mL). The resulting solution was stirred for 4 h at 80 C. The resulting mixture was concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with dichloromethane/methanol (20: 1). This resulted in 34 mg (58%) of 1-8 as a yellow solid. LC-MS (ESI, m/z): 398 (M+H+); MR (300 MHz, CD3OD) delta 8.62 (s, 1H), 7.94 (s, 1H), 7.86 (s, 1H), 7.65 (s, 1H), 4.24 (m, 1H), 3.98 (m, 4H), 3.89 (s, 3H), 3.42 (s, 4H), 2.34 (m, 4H), 1.53-1.76 (m, 4H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 127107-23-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.

4- ( (IS, 2R) -2- ( (tert-Butoxycarbonyl) amino) cyclopropyl) -5- methylthiophene-2-carboxylic acid (3.06 g) , 1-methyl.-1H- pyrazol-4-amine hydrochloride (1.37 g) and triethylamine (5.73 mL) were dissolved in DMF (30 mL) , 0- (7-azabenzotriazol-l-yl) – Nu,Nu,Nu’ ,Nu’ -tetramethyluronium hexafluorophosphate (4.69 g) was added, and the mixture was stirred at 40C overnight. Water was added to the reaction mixture, and the mixture wasextracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogen carbonate solution, water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate and methanol/ethyl acetate) to give the title compound (3.7 g) .MS: [M+H]+377.1

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-4-amine hydrochloride. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

Into a 100 mL round-bottom flask under inert atmosphere were placed interemediate 55.1 (200 mg, 0.54 mmol, 1.00 equiv), 2-methylpropan- 2-ol (10 mL), potassium phosphate (346 mg, 1.63 mmol, 3.00 equiv), 1-methyl-1H-pyrazol-4- amine hydrochloride (109 mg, 1.12 mmol, 1.50 equiv), and 3T generation xphos precatalyst (43 mg, 0.05 mmol, 0.10 equiv). The resulting solution was stirred overnight at room temperature. The resulting mixture was concentrated under vacuum and crude was purified using preparative HPLC to furnish 84.4 mg (36%) of compound 1-55 as a pink solid. LCMS (ES, m/z): 430 [M+H] ?H NMR (400 MHz ,CD3OD): oe 7.53 1 (s, 1H), 7.8777.913 (d, 1H), 5.1565.225 (m, 1H), 3.8503.886 (d, 3H), 3.6763.707 (t, 4H), 2.6822.725 (d, 3H), 2.5852.616 (t, 4H), 2.2892.360 (m, 3H), 2.0692.113 (d, 2H), 1.5041.596 (t, 2H), 1.5961.681 (t, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.