Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives
Into a 100 mL round-bottom flask under inert atmosphere were placed interemediate 55.1 (200 mg, 0.54 mmol, 1.00 equiv), 2-methylpropan- 2-ol (10 mL), potassium phosphate (346 mg, 1.63 mmol, 3.00 equiv), 1-methyl-1H-pyrazol-4- amine hydrochloride (109 mg, 1.12 mmol, 1.50 equiv), and 3T generation xphos precatalyst (43 mg, 0.05 mmol, 0.10 equiv). The resulting solution was stirred overnight at room temperature. The resulting mixture was concentrated under vacuum and crude was purified using preparative HPLC to furnish 84.4 mg (36%) of compound 1-55 as a pink solid. LCMS (ES, m/z): 430 [M+H] ?H NMR (400 MHz ,CD3OD): oe 7.53 1 (s, 1H), 7.8777.913 (d, 1H), 5.1565.225 (m, 1H), 3.8503.886 (d, 3H), 3.6763.707 (t, 4H), 2.6822.725 (d, 3H), 2.5852.616 (t, 4H), 2.2892.360 (m, 3H), 2.0692.113 (d, 2H), 1.5041.596 (t, 2H), 1.5961.681 (t, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.