Electric Literature of 127107-23-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 127107-23-7 name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 2-bromo-N-(l-hydroxy-2-methylpropan-2-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)- 5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (150 mg, 338 muiotaetaomicron), l-methyl-lH-pyrazol-4-amine hydrochloride (67.8 mg, 526 muiotaetaomicron), BINAP (10.5 mg, 16.9 muiotaetaomicron), palladium (II) acetate (19.0 mg, 84.6 muiotaetaomicron) and sodium iert-butoxide (81.3 mg, 846 muiotaetaomicron) in DMF (1 mL) and toluene (500 munu> was heated in a microwave at 140C for 20 min. The reaction mixture was diluted with water then extracted into ethyl acetate (3x). The combined organic extracts were washed with brine then dried over magnesium sulfate. Purification by chromatography (silica, 20-65 % of a 10:89.5:0.5 methanol :dichloromethane: ammonium hydroxide solution in dichloromethane) gave N-(l-hydroxy-2-methylpropan-2-yl)-2-(l -methyl- lH-pyrazol-4-ylamino)-5-((2- (trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (28 mg, 60.9 muiotaetaomicron, 18 %) as a light yellow solid. (EI/CI) m/r. 460.3 [M + H].
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazol-4-amine hydrochloride, and friends who are interested can also refer to it.