Electric Literature of 127107-23-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 127107-23-7 name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Into a 20 mL round-bottom flask under nitrogen, were placed intermediate 50.3 (83 mg, 0.21 mmol, 1.00 equiv), butan-1-ol (2 mL) and 1-methyl-1H- pyrazol-4-amine hydrochloride (32 mg, 0.39 mmol, 1.20 equiv). The reaction was stirred overnight at 110 C in an oil bath, then concentrated under vacuum. The resulting solution was diluted with 0.5 mL of sodium bicarbonate and concentrated under vacuum. The resulting solution was extracted with DCM/IPA (3/1), and the organic layers were combined and concentrated under vacuum. The crude product was purified using flash column chromatography to furnish 11.4mg (12%) of compound I-SO as a brown solid. LCMS; (ES, m/z): 471 [M+H] ?H NMR (400 MHz, CD3OD): oe 7.828 (s, 1H), 7.526 (s, 1H), 3.842 (s, 3H), 3.6793.710 (m, 4H), 2.5962.626 (m, 4H), 2.216 (s, 3H), 2.0672.082 (d, 2H), 1.3951.460 (m, 13H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazol-4-amine hydrochloride, and friends who are interested can also refer to it.