Tag: M.W:200-300

Related Products of 20055-01-0, These common heterocyclic compound, 20055-01-0, name is 1-Methyl-1H-pyrazole-4,5-diamine sulfate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of 1, 1′-CARBONYLDIIMIDAZOLE (973 mg) in methylene chloride (10 ml) was added 0- [2- (tert- butoxycarbonylamino) ethyl] hydroxylamine (1.11 g) under ice-cooling, and the mixture was stirred at room temperature for 2 hours. To the reaction mixture were added N-ethyldiisopropylamine (1.28 g) and 4,5-diamino- 1-methylpyrazole sulfuric acid salt (1.05 g), and the mixture was stirred under reflux for 4 hours. The reaction mixture was washed with brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with 10% methanol/chloroform to give 5-amino-4- (3- {2- [ (TERT-BUTOXYCARBONYL) amino] ethoxy} UREIDO)-1- methylpyrazole (255 mg) as a solid. H-NMR (DMSO-d6) 8 1.38 (9H, s), 3.19-3. 20 (2H, m), 3.51 (3H, s), 3.72 (2H, t, J=6Hz), 4.86 (2H, br), 6.95 (1H, br), 7.06 (1H, s), 8.02 (1H, brs), 9.15 (1H, brs)

The synthetic route of 20055-01-0 has been constantly updated, and we look forward to future research findings.

Reference of 39806-90-1, A common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 4-Iodo-1-methyl-1H-pyrazole 1 (101 mg, 0.5 mmol) and phenylboronic 2 (59 mg, 0.5 mmol) were dissolved in DME (3 mL) and H2O (1.2 mL) in a microwave vial under a nitrogen atmosphere. Pd(PPh3)4 (2 mmol%, 11.6 mg) and Cs2CO3 (407.3 mg, 1.25 mmol) were added, and the reaction mixture was irradiated in a microwave apparatus at 90 C for 5-12 min. After the reaction mixture was cooled to ambient temperature, the product was concentrated, and the crude mixture was purified by silica gel column chromatography using petroleum ether/acetone as eluent to give the title compound.

The synthetic route of 39806-90-1 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 30169-25-6, name is 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine, A new synthetic method of this compound is introduced below., name: 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine

Compound 1 (270 mg, 1.0 mmol) was placed in a 50 ml round bottomed flask. acetonitrile (10 ml) was added. 1,4 phenylene diamine (108 mg, 1.0 mmol) was added and the reaction heated to reflux for 1 hour. The reaction was allowed to cool to ambient temperature and the precipitate was isolated by filtration. The product was washed with cold acetonitrile, and air dried to give 225 mg of a purple solid (80% yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 39806-90-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A suspension of 5-chloro-lH-pyrazolo[3,4-c]pyridine (300 mg, 1.95 mmol), 4- iodo-l-methylpyrazole (600 mg, 2.88 mmol), 2-isobutyrylcyclohexanone (130 mg, 0.773 mmol), copper(I) iodide (75 mg, 0.39 mmol) and cesium carbonate (1.5 g, 4.60 mmol) in 5 mL of DMA was deoxygenated by bubbling nitrogen for 15 min. Next, the reaction mixture was warmed to (0809) 100C and stirred overnight. The reaction mixture was then cooled and diluted with DCM, washed with 1 N aqueous NaOH and water, dried (Na2S04) and concentrated to dryness. The solid residue was suspended in ether and filtered to collect the desired intermediate, 5-chloro-l- (0810) (l-methyl-lH-pyrazol-4-yl)-lH-pyrazolo[3,4-c]pyridine: MS (EI) calc’d for Ci0H9ClN5 [M+H]+ (0811) 234, found 234; 1H NMR (600 MHz, OMSO-d6) delta 9.02 (s, 1 H), 8.41 (s, 1 H), 8.38 (s, 1 H), 7.97 (0812) (s, 1 H), 7.96 (s, 1 H), 3.91 (s, 3 H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Application of 1015868-48-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1015868-48-0 name is 3-(4-Chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: After hydrolysis of the ester, thionyl chloride (0.025mol) and catalytic amount of DMF were added to the solution of acid derivative (0.01mol) in CH2Cl2 under argon atmosphere and refluxed for 3h. Then, to the reaction mixture, diisopropylethylamine (0.015mol) and piperidine (0.01mol) were added and stirred overnight at room temperature. After the reaction was complete, the solvent was evaporated and the residue was purified by flash chromatography using CH2Cl2: MeOH solvent gradient.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(4-Chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H15N3O2

Synthesis of 257-A and 258-A. A mixture of tert-butyl 4,6-dihydropyrrolo[3,4- c]pyrazole-5(2H)-carboxylate (314 mg, 1.50 mmol), Cs2CO3 (978 mg, 3.00 mmol) and iodomethane (320 mg, 2.25 mmol) in DMF (6 mL) was stirred at room temperature for 16 h. The mixture was diluted with water (18 mL), extracted with EtOAc (10 mL × 3). The combined organic layer was washed with brine (10 mL × 3), dried over anhydrous Na2SO4 and then concentrated in vacuo. The residue was purified by column chromatography on silica gel (DCM : MeOH = 100 : 1 ~ 50 : 1) to give 257-A and 258-A (270 mg, 81%) as a yellow solid.

The synthetic route of 1280210-79-8 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 1280210-79-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Dissolve 2,6-dihydropyrrolo [3,4-c] pyrazole-5(4H)-tert-butyl carboxylate (12 g, 56.7 mmol) in acetonitrile (100 mL),Add 1-bromo-3- (bromomethyl) -5-methoxybenzene 4b (19 g, 68.1 mmol), Cesium carbonate (64.8 g, 199 mmol), Nitrogen was replaced 3 times, and the reaction was performed in an 80 C oil bath for 3 hours. Filtering the reaction solution,The filtrate was concentrated. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 2: 1) to obtain 2-(3-bromo-5-methoxybenzyl)-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-tert-butyl carboxylate 4c (23 g, yellow oil), yield: 82.9%.

The chemical industry reduces the impact on the environment during synthesis tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate. I believe this compound will play a more active role in future production and life.

Application of 345637-71-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 345637-71-0 name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step F: Preparation of 1-[4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperazinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone To a solution of 1-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]piperazine hydrochloride (i.e. the product of Example 7, Step E) (200 mg, 0.57 mmol) and 5-methyl-3-(trifluoromethyl)-1H-pyrazole-1-acetic acid (0.120 g, 0.57 mmol) in dichloromethane (10 mL) at room temperature was added 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.110 g, 0.57 mmol), triethylamine (0.086 g, 0.85 mmol) and 1-hydroxy-benzotriazole hydrate (0.020 g, 0.14 mmol). The reaction mixture was stirred at room temperature for 24 h. The reaction mixture was diluted with dichloromethane (30 mL) and washed with water (20 mL) and brine (20 mL). The organic layer was dried (Na2SO4) and concentrated under reduced pressure. The crude residue was purified by column chromatography using 3% methanol in chloroform as eluant to give 180 mg of the title product as a white solid. 1H NMR (CDCl3): delta 2.32 (s, 3H), 3.29 (m, 1H), 3.52 (m, 2H), 3.61 (m, 2H), 3.79-3.72 (m, 5H), 4.98 (m, 2H), 5.69 (m,1H), 6.33 (s, 1H), 6.93 (s, 1H), 7.38-7.28 (m, 5H). Mass spectrum at 505.5 (M+1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, and friends who are interested can also refer to it.

Reference of 141573-95-7, A common heterocyclic compound, 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C8H10F2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

l,2,3,4-tetrahydro-9-isopropyl-l,4-methanonaphthalen-5-amine320 mg (1 eq. ; 9: 1 syn:anti mixture) in 2 ml THF and 325 mg (1.6 mmol)DFMMP (1) in 2 ml THF were added to a suspension of 268mg (1.5 eq.) KOtBu in 10 ml THF at 0C. After stirring at room temperature over night the reaction mixture was poured out in water and extracted twice with acetic ether. The purified organic extracts were washed with water and a saturated NaCl solution, dried, filtered and concentrated over sodium sulphate. The residue was filtrated through a silicagel column (Si02 ; hexane/acetic ether 1 : 1) and the desired product Isopyrazam was obtained in 77 % yield (440 mg) (purity GC 100 % ; HPLC – 254nm > 99 % as 86.5: 12.7 symanti mixture).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 10250-64-3,Some common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, molecular formula is C11H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 19 (1.2 eq) and HOBt(1.4 eq) in DMF (0.5 M) were added EDCI (1.3 eq) and a solution of 15a-j or 16a-j (1.0 eq) in DMF (0.25 M), Et3N (3.5 eq) at 0 C. The reaction mixture was stirred at room temperature for 24 hours, then diluted in AcOEt. The organic phase was washed with water twice, saturated aqueous NaHCO3 three times, and brine, then dried over Na2SO4,filtered, and concentrated. The residue was purified by flash column chromatography to give intermediates 17a-j and 18a-j.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, its application will become more common.