Related Products of 20055-01-0, These common heterocyclic compound, 20055-01-0, name is 1-Methyl-1H-pyrazole-4,5-diamine sulfate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of 1, 1′-CARBONYLDIIMIDAZOLE (973 mg) in methylene chloride (10 ml) was added 0- [2- (tert- butoxycarbonylamino) ethyl] hydroxylamine (1.11 g) under ice-cooling, and the mixture was stirred at room temperature for 2 hours. To the reaction mixture were added N-ethyldiisopropylamine (1.28 g) and 4,5-diamino- 1-methylpyrazole sulfuric acid salt (1.05 g), and the mixture was stirred under reflux for 4 hours. The reaction mixture was washed with brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with 10% methanol/chloroform to give 5-amino-4- (3- {2- [ (TERT-BUTOXYCARBONYL) amino] ethoxy} UREIDO)-1- methylpyrazole (255 mg) as a solid. H-NMR (DMSO-d6) 8 1.38 (9H, s), 3.19-3. 20 (2H, m), 3.51 (3H, s), 3.72 (2H, t, J=6Hz), 4.86 (2H, br), 6.95 (1H, br), 7.06 (1H, s), 8.02 (1H, brs), 9.15 (1H, brs)
The synthetic route of 20055-01-0 has been constantly updated, and we look forward to future research findings.