Application of 39806-90-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A suspension of 5-chloro-lH-pyrazolo[3,4-c]pyridine (300 mg, 1.95 mmol), 4- iodo-l-methylpyrazole (600 mg, 2.88 mmol), 2-isobutyrylcyclohexanone (130 mg, 0.773 mmol), copper(I) iodide (75 mg, 0.39 mmol) and cesium carbonate (1.5 g, 4.60 mmol) in 5 mL of DMA was deoxygenated by bubbling nitrogen for 15 min. Next, the reaction mixture was warmed to (0809) 100C and stirred overnight. The reaction mixture was then cooled and diluted with DCM, washed with 1 N aqueous NaOH and water, dried (Na2S04) and concentrated to dryness. The solid residue was suspended in ether and filtered to collect the desired intermediate, 5-chloro-l- (0810) (l-methyl-lH-pyrazol-4-yl)-lH-pyrazolo[3,4-c]pyridine: MS (EI) calc’d for Ci0H9ClN5 [M+H]+ (0811) 234, found 234; 1H NMR (600 MHz, OMSO-d6) delta 9.02 (s, 1 H), 8.41 (s, 1 H), 8.38 (s, 1 H), 7.97 (0812) (s, 1 H), 7.96 (s, 1 H), 3.91 (s, 3 H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.