Tag: M.W:100-200

These common heterocyclic compound, 4522-35-4, name is 3-Iodo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 4522-35-4

INTERMEDIATE 11 l-(4-Chlorophenyl)-3-iodo-lH-pyrazole To 3 -iodo- 1 H-pyrazole (743 mg, 3.83 mmol) in DMSO (10 mL) at 0 C, was added sodium hydride (60% in mineral oil, 184 mg, 4.60 mmol). The reaction was warmed to 25 C and stirred for 60 min before l-chloro-4-fluorobenzene (500 mg, 4.13 mmol) was added. The reaction mixture was stirred at 90 C for 2 days before quenching by the addition of water. The reaction mixture was extracted with EtOAc. The combined organic extracts were dried over MgS04 and concentrated in vacuo. The crude mixture was purified by flash chromatography (ISCO Combiflash, 0-20% EtOAc in hexanes) to give product, as a white solid. LCMS calc. = 304.93; found = 304.92 (Mu+Eta)+. NMR (500 MHz, CDC13): delta 7.73 (d, J= 2.5 Hz, 1 H); 7.64-7.61 (m, 2 H); 7.46-7.43 (m, 2 H); 6.66 (d, J= 2.5 Hz, 1 H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4522-35-4.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15366-34-4 as follows. 15366-34-4

a) Methyl 1-(2-methylprop-1-enyl)-1H-pyrazole-3-carboxylate The title compound was prepared using the procedure described in Example 17(a) starting from methyl 1H-pyrazole-3-carboxylate (8 g, 63.4 mmol) and 1-bromo-2-methyl propene (12.7 g, 95.2 mmol). The product was purified with flash chromatography. Yield 2.4 g. 1H-NMR (400 MHz; CDCl3): delta 1.81 (d, 3H), 1.87 (d, 3H), 3.93 (s, 3H), 6.70 (d, 1H), 6.87 (d, 1H), 7.47 (d, 1H).

According to the analysis of related databases, 15366-34-4, the application of this compound in the production field has become more and more popular.

5932-27-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of tert-butyl ((2-chloro-6-((4,4- difluorocyclohexyl)amino)pyrimidin-4-yl)methyl)carbamate [003 ij (4.2 g, 15.178 mmol) and ethyl-1H-pyrazole-3-carboxylate [0005j (4.2 g, 15.178 mmol) in acetonitrile was added cesium carbonate (4.2 g, 15.178 mmol) and the reaction mixture was heated at 85 ¡ãC in sealed tube. After 2 h, the reaction mixture was filtered, washed with chloroform (50 mL). The combined filtrate was concentrated under reduced pressure to afford pale brown oil which was purified by column chromatography using 35percent ethyl acetate in hexane as eluent to afford ethyl 1 -(4-(((tert-butoxycarbonyl)amino)methyl)-6-((4,4- difluorocyclohexyl)amino)pyrimidin-2-yl)- 1 H-pyrazole-3 -carboxylate [0032j as a pale yellow solid (2.2 g). MS(M+1)=481.3.

The synthetic route of 5932-27-4 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 113100-53-1 as follows. 113100-53-1

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid 3 (7.50 mmol) and SOCl2 (30 mmol) were refluxed for 4 h. After the reaction is completed, the excess of SOCl2 was evaporated to give 4 as a yellow liquid that was used without further purification.

According to the analysis of related databases, 113100-53-1, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 15366-34-4, name is Methyl 1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 15366-34-4

A mixture of methyl liT-pyrazole-3-carboxylate (500.0 mg, 3.96 mmol), 3- methoxyphenyl boronic acid (901.0 mg, 5.9 mmol), Cu(OAc)2 (1.43 g, 7.9 mmol) and TEA (2.7 mL, 19.7 mmol) in DCM (15 mL) was stirred at 40 C for 12 h under 02 atmosphere. The reaction mixture was then filtered. The filtrate was concentrated, and the residue was purified by flash silica gel chromatography (80 g column, EtOAc in petroleum ether from 0% -30%) to give methyl l-(3-methoxyphenyl)-liT-pyrazole-3-carboxylate (190 mg, 21% yield, the higher polarity) as a yellow oil ( LC-MS (ESI+) m/z: 232.9 (M+H)+) and methyl l-(3-methoxyphenyl)-liT-pyrazole-5-carboxylate (30.0 mg, 3% yield) as a yellow solid( LC-MS (ESI+) m/z: 232.9 (M+H)+).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15366-34-4.

14521-80-3, A common heterocyclic compound, 14521-80-3, name is 3-Bromo-1H-pyrazole, molecular formula is C3H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To compound 246.la (4g, 15.9mmol, 1.Oeq) and compound 1.2 (3.69g, 17.5mmol, 1.leq) in tetrahydrofuran (32mL), sodium carbonate (4.3g, 31.8mmol, 2.Oeq) was added. Reaction mixture was degassed for 5 mm. Then, [1,1?- Bis(diphenylphosphino)ferrocene]dichloropalladium(II) (1.16g, 1.59mmol, 0.leq) was added and again degassed for 5 mm. Reaction mixture was stirred at 120 C for 4h. After completion of the reaction, the reaction mixture was transferred to water and extracted with ethyl acetate. Organic layers were combined, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to get the crude material. This was purified by column chromatography using 13% ethyl acetate in hexane as eluant to obtain 287.1 (2.Og, 15.49%). MS(ES): m/z 238.46 [M+H]t

The synthetic route of 14521-80-3 has been constantly updated, and we look forward to future research findings.

16617-46-2, These common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

– Synthesis of Intermediate Compound (4) – 4.5 parts of Compound (3) was added to 45 parts of phosphoric acid and dissolved by heating at 38¡ãC. The resulting solution was cooled on ice and kept at -3 to 0¡ãC, and 3.0 parts of sodium nitrite were added thereto and stirred for 1 hour to give a diazonium salt solution. Separately, 10 parts of Compound (2) synthesized above were dissolved in 30 parts of methanol to prepare a solution of Compound (2). The above diazonium salt solution was added thereto at 8¡ãC or less. Simultaneously with the completion of the addition, the ice bath was removed, and the mixture was stirred for 2 hours. The reaction solution was added to 300 parts of water at 10¡ãC under stirring and stirred for additional 1 hour. Precipitated crystals were separated by filtration and sufficiently washed with water. The crystals were dried to give 12.5 parts of Intermediate Compound (4). The yield was 83.4percent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16617-46-2.

14521-80-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14521-80-3, name is 3-Bromo-1H-pyrazole, A new synthetic method of this compound is introduced below.

Production Example 1; (1) A mixture of 10.7 g of 3-bromo-1H-pyrazole, 11.8 g of 2,3-dichloropyridine, 57.3 g of cesium carbonate and 80 mL of N,N-dimethylformamide was stirred at 100C for 8 hours. After cooling to room temperature and adding water, the reaction mixture was extracted twice with methyl tert-butyl ether. The organic layers were combined, washed sequentially with water and a saturated sodium chloride solution, dried over magnesium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography to obtain 12.9 g of 2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine. 2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine 1H-NMR (CDCl3, TMS) delta (ppm): 6.51 (1H, d, J=2Hz), 7.31 (1H, dd, J=8Hz, 4hz), 7.91 (1H, dd, J=8Hz, 1Hz), 8.04 (1H, d, J=2Hz), 8.45 (1H, dd, J=4Hz, 1Hz)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

5334-40-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

N-Benzylthanolamine (2.147 mL, 1.06 g/mL, 15.052 mmol) and 4-nitro-1H-pyrazole-3- carboxylic acid (2 g, 12.732 mmol) in toluene (13.8 14 mL) were stirred at 15¡ãC. SOC12 (2.554 mL, 1.64 g/mL, 35.206 mmol) was slowly added followed by DMF (96.907 jiL,0.944 g/mL, 1.252 mmol). The reaction mixture was stirred at 55¡ãC for 10 minutes then70¡ãC for 1 8h. The reaction was allowed to cool to room temperature and then the solvents were evaporated in vacuo. The residue was taken up into DMF (11.655 mL) and triethylamine (9.4 15 mL, 0.728 g/mL, 67.732 mmol) was added slowly. The reaction mixture was stirred at rt for 1 2h. Water was added. The mixture was extracted twice withEtOAc, dried over MgSO4, filtered and concentrated in vacuo to give 4.4g of crude material. A purification was performed via preparative LC (Stationary phase: irregular SiOH 15-40jim 120g Grace, Mobile phase: gradient from 100percent DCM to 97percent DCM, 3percent MeOH, 0.3percentNH4OH) to give 1.7g of intermediate 133b (41percent).

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These common heterocyclic compound, 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 25016-11-9

General procedure: To a solution of S2 (50 mg, 0.2 mmol) in 1,2-dichloroethane (DCE, 1 mL) was added aldehyde(1.1 equiv), sodium triacetoxyborohydride (79 mg, 0.5 mmol) and AcOH (25 muL, 0.5 mmol) at roomtemperature. The solution was stirred for 16 h and concentrated. The solution was extracted withethyl acetate (3 mL), washed with citric acid solution, saturated NaHCO3, and concentrated. Theremaining residue was dissolved in THF and chloroacetyl chloride (23.8 muL, 0.3 mmol) was thenadded at 0 C. The solution was warmed to room temperature and stirred for 2 h. The solutionwas concentrated and separated by preparative TLC to afford RS004 analogues.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25016-11-9.