5334-40-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
N-Benzylthanolamine (2.147 mL, 1.06 g/mL, 15.052 mmol) and 4-nitro-1H-pyrazole-3- carboxylic acid (2 g, 12.732 mmol) in toluene (13.8 14 mL) were stirred at 15¡ãC. SOC12 (2.554 mL, 1.64 g/mL, 35.206 mmol) was slowly added followed by DMF (96.907 jiL,0.944 g/mL, 1.252 mmol). The reaction mixture was stirred at 55¡ãC for 10 minutes then70¡ãC for 1 8h. The reaction was allowed to cool to room temperature and then the solvents were evaporated in vacuo. The residue was taken up into DMF (11.655 mL) and triethylamine (9.4 15 mL, 0.728 g/mL, 67.732 mmol) was added slowly. The reaction mixture was stirred at rt for 1 2h. Water was added. The mixture was extracted twice withEtOAc, dried over MgSO4, filtered and concentrated in vacuo to give 4.4g of crude material. A purification was performed via preparative LC (Stationary phase: irregular SiOH 15-40jim 120g Grace, Mobile phase: gradient from 100percent DCM to 97percent DCM, 3percent MeOH, 0.3percentNH4OH) to give 1.7g of intermediate 133b (41percent).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.