14521-80-3, A common heterocyclic compound, 14521-80-3, name is 3-Bromo-1H-pyrazole, molecular formula is C3H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To compound 246.la (4g, 15.9mmol, 1.Oeq) and compound 1.2 (3.69g, 17.5mmol, 1.leq) in tetrahydrofuran (32mL), sodium carbonate (4.3g, 31.8mmol, 2.Oeq) was added. Reaction mixture was degassed for 5 mm. Then, [1,1?- Bis(diphenylphosphino)ferrocene]dichloropalladium(II) (1.16g, 1.59mmol, 0.leq) was added and again degassed for 5 mm. Reaction mixture was stirred at 120 C for 4h. After completion of the reaction, the reaction mixture was transferred to water and extracted with ethyl acetate. Organic layers were combined, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to get the crude material. This was purified by column chromatography using 13% ethyl acetate in hexane as eluant to obtain 287.1 (2.Og, 15.49%). MS(ES): m/z 238.46 [M+H]t
The synthetic route of 14521-80-3 has been constantly updated, and we look forward to future research findings.