16617-46-2, These common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
– Synthesis of Intermediate Compound (4) – 4.5 parts of Compound (3) was added to 45 parts of phosphoric acid and dissolved by heating at 38¡ãC. The resulting solution was cooled on ice and kept at -3 to 0¡ãC, and 3.0 parts of sodium nitrite were added thereto and stirred for 1 hour to give a diazonium salt solution. Separately, 10 parts of Compound (2) synthesized above were dissolved in 30 parts of methanol to prepare a solution of Compound (2). The above diazonium salt solution was added thereto at 8¡ãC or less. Simultaneously with the completion of the addition, the ice bath was removed, and the mixture was stirred for 2 hours. The reaction solution was added to 300 parts of water at 10¡ãC under stirring and stirred for additional 1 hour. Precipitated crystals were separated by filtration and sufficiently washed with water. The crystals were dried to give 12.5 parts of Intermediate Compound (4). The yield was 83.4percent.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16617-46-2.