Tag: M.W:100-200

Reference of 1780-72-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1780-72-9 name is 4-Bromo-5-methyl-1H-pyrazol-3-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[Pt(bpma)(pzBr)]Cl2·2H2O was synthesized with reaction of the methanolic solution of pzBr (0.0022 g,12.4 muM, 4 cm3) and aqueous solution of [Pt(bpma)Cl]Cl (0.006 g, 12.4 muM, 5 cm3) mixed in molar ratio1 : 1. pH of the colorless solution was maintained at 7 because [Pt(bpma)Cl]Cl could be converted intothe unreactive hydroxo species at higher pH. The mixture was stirred for 24 h and after two days the colorless crystal product was filtered off and washed with methanol. The crystals of the complex aremechanically separated for X-ray analysis. Anal Calcd for C16H23Cl2BrN6O2Pt (%) FW = 677.28: C, 28.37; H,3.42; N, 12.41. Found: C, 28.29; H, 3.48; N, 12.10; UV-vis: lambdamax (nm) = 245; 271, 1H NMR, 200 MHz, D2O: delta(ppm): 1.89 (s, 3H, CH3-pzBr); 3.76 (s, 4H, CH2-bpma); 7.42 (t, 2H, J = 6.8 Hz, H4-bpma); 7.68 (d, 2H, J = 8 Hz,H3-bpma); 7.74 (d, 2H, J = 6.8 Hz, H6-bpma), 8.18 (t, 2H, J = 8 Hz, H5-bpma). IR (KBr, 4000-300 cm-1):3500-3200 (N-H stretch, O-H stretch); 3150-2850 (-CH stretch,=CH stretch); 1630 (C=N stretch); 787(N-H wagging) (figures 1S-3S, supplementary material).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-5-methyl-1H-pyrazol-3-amine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 121507-34-4, name is 5-Isopropoxy-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 121507-34-4, COA of Formula: C6H11N3O

6-chloro-N’-(5-isopropoxy-1H-pyrazol-3-yl)-N-[(3-methylisoxazol-5-yl)methyl]pyrimidine-2,4-diamine (also known as 6-chloro-N-[(3-methyl-1,2-oxazol-5-yl)methyl]-N’-(5-propan-2-yloxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine), used as starting material, was prepared as follows: a) A solution of 2,4,6-trichloropyrimidine (1.3 g, 7.08 mmol) and sodium carbonate (0.751 g, 7.08 mmol) in ethanol (20 ml) was cooled to 0 C. and then 5-isopropoxy-1H-pyrazol-3-amine (1.0 g, 7.08 mmol) was added. The mixture was stirred at room temperature overnight and then evaporated. The residue was taken up in ethyl acetate (50 ml) and washed with water (50 ml) and then with brine (25 ml). The organic extracts were dried over magnesium sulfate, filtered and then evaporated to leave a yellow oil. The oil was purified by chromatography on silica eluting with a mixture of 25-60% ethyl acetate in iso-hexane. The fractions containing product were combined and evaporated to leave a solid that was triturated with diethyl ether to give 2,6-dichloro-N-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidin-4-amine (1.06 g, 52% yield). 1HNMR(400 MHz, DMSO 373K): 1.31 (d, 6H), 4.5 (bs, 1H), 5.62 (s, 1H), 7.19 (bs, 1H), 10.16 (bs, 1H), 11.72 (bs, 1H).MS: m/z 288 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Isopropoxy-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 112758-40-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112758-40-4 name is 3-Methyl-1H-pyrazole-4-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 3 -methyl- lH-pyrazole-4-carbaldehyde (5 g, 45.41 mmol), potassium carbonate (9.41 g, 68.11 mmol), 2,3-difluorobenzonitrile (6.06 mL, 54.5 mmol) and dimethylformamide (50 mL) is stirred at 100C for 5 hr. and then at room temperature overnight. Water is added and a precipitated is formed. The precipitate is filtered. The aqueous solution filtered is extracted in ethyl acetate. Organic layer is washed with brine, dried over magnesium sulfate and solvent is evaporated. Both the solid precipitated and the solid recovered from organic layer after evaporation are combined and 10.4 g of the title compound is obtained and used with no further purification (the title compound is contaminated with the other pyrazole regioisomer in a ratio 90: 10). MS (m/z): 230 (M+l). To a suspension of 2-chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4′- piperidine] hydrochloride (1.3 g, 4.11 mmol) in 1,2-dichloroethane (20.5 mL) is added triethylamine (0.75 mL, 5.3 mmol) and 3-fluoro-2-(4-formyl-3-methyl-pyrazol-l-yl)- benzonitrile (as major compound in a mixture of regioisomers) (1.13 g, 4.93 mmol). The mixture is stirred at room temperature for 30 min. Then, sodium triacetoxyborohydride (1.82 g, 8.22 mmol) is added. The mixture is stirred at room temperature overnight. After that time, solvent is evaporated and the residue is diluted with methanol and purified using a 50 g SCX cartridge and then by normal phase Isco chromatography eluting with dichloromethane and methanol to give 1.6 g of a crude material containing a mixture of regioisomers (80:20 aprox). This residue is further purified by reverse phase HPLC to give 927 mg of 2-[4-[(2-chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4′-piperidine]- r-yl)methyl]-3-methyl-pyrazol-l-yl]-3-fluoro-benzonitrile as the major regioisomer. MS (m/z): 493 (M+l).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methyl-1H-pyrazole-4-carbaldehyde, and friends who are interested can also refer to it.

Application of 2075-46-9,Some common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: Preparation of 1-benzyl-4-nitro-pyrazole To a stirred solution of 4-nitro-1H-pyrazole (2.00 g, 17.7 mmol) in N,N-dimethylformamide (15 mL) was added sodium hydride (0.778 g, 19.0 mmol, 60% purity in mineral oil) at 0 C. The reaction mixture was stirred at 15 C. for 1 h and then cooled to 0 C. before benzyl bromide (2.10 mL, 17.7 mmol) was added. The reaction mixture was warmed to 15 C. and stirred for 15 h then quenched by adding ice water (5 mL) and extracted with ethyl acetate (15 mL*3). The combined organic layers were washed with water (10 mL*2) and brine (5 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (ISCO, 20 g silica, 0-30% ethyl acetate in petroleum ether, gradient over 20 min) to give 1-benzyl-4-nitro-pyrazole (2.80 g, 13.8 mmol, 78%) as a white solid. 1H NMR (400 MHz, Chloroform-d) delta 8.10 (s, 1H), 8.04 (s, 1H), 7.45-7.39 (m, 3H), 7.32-7.28 (m, 2H), 5.31 (s, 2H); LCMS (ESI) m/z: 204.1 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Nitro-1H-pyrazole, its application will become more common.

Electric Literature of 4522-35-4, These common heterocyclic compound, 4522-35-4, name is 3-Iodo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

INTERMEDIATE 23 Methyl 4-(3-iodo- lH-pyrazol- 1 -yl)picolinate To 3-iodo-lH-pyrazole (625 mg, 3.22 mmol) in DMSO (15 mL) at 0 C,was added sodium hydride (60% in mineral oil, 155 mg, 3.87 mmol). The reaction was stirred for 30 min before methyl 4-fluoropicolinate (500 mg, 3.22 mmol) was added and the reaction was stirred at 90 C for 4.5 h. The reaction mixture was quenched by the addition of water and the mixture was extracted with EtOAc. The combined organic extracts were dried over MgS04 and concentrated in vacuo. The crude mixture was purified by flash chromatography (ISCO Combiflash, 0-100%) EtOAc in hexanes) to afford methyl 4-(3-iodo-lH-pyrazol-l-yl)picolinate, as a colorless solid. LCMS calc. = 329.97; found = 329.88 (M+H)+.

Statistics shows that 3-Iodo-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 4522-35-4.

151049-87-5, name is 3-Bromo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3-Bromo-1-methyl-1H-pyrazole

0583-1 A suspension of 5-bromothiazole (200 mg), bis(pinacolato)diboron (371 mg), (1,1′-bis(diphenylphosphino)ferrocene)palladium(II) dichloride (98 mg) and potassium acetate (296 mg) in 1,4-dioxane (6 mL) was stirred at 100 C. for 2 hours in a nitrogen atmosphere. 3-Bromo-1-methyl-1H-pyrazole (194 mg), water (0.6 mL), sodium carbonate (320 mg), and bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II) (42 mg) were added to the reaction mixture, followed by stirring at 100 C. for 2 hours. The reaction mixture was cooled to room temperature, the insolubles were filtered off, and the obtained residue was purified by silica gel column chromatography (methanol-ethyl acetate), thereby obtaining 5-(1-methyl-1H-pyrazol-3-yl)thiazole (16 mg). MS m/z (M+H): 166.

The synthetic route of 151049-87-5 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1151814-36-6, name is 1-Cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1151814-36-6, Computed Properties of C6H8N2

To a solution of crude 1 -cyclopropyl- lH-pyrazole (108 mg, 1.00 mmol) in CEtaCI3 (4 mL) at room temperature was added Br2 (51 uL, 1.0 mmol) via syringe. The orange solution was stirred for 1 h. The reaction was diluted with saturated aqueous Na2S2O3 (3 mL) and saturated aqueous NaHCO3 (3 mL). The mixture was extracted with CH2Cl2 (3 x 5 mL). The combined organic layers were dried over Na2Stheta4 and concentrated on a rotary evaporator without heating the sample to give 4-bromo-l -cyclopropyl- lH-pyrazole as a volatile, light yellow liquid that was used without further purification, m/z 187.3 [M + H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Product Details of 96799-02-9

To a solution of compound 2 (300 mg, 0.88 mmol) in THF (5 mL) a solution of 3- amino-5-92-furyl)pyrazole (105 mg, 0.70 mmol) and DIPEA (0.16 mL, 0.88 mmol) was added in 10-20 mL microwave vial. Vial was sealed with a cap and the mixture was allowed to stir at 150 0C for 5 minutes in the microwave synthesizer. Next, 1 -methyl piperazine (0.15 mL, 1.32 mmol) and DIPEA (0.23 mL, 1.32 mmol) were added to the above mixture and allowed to stir at 60 0C for 10 min. in the microwave synthesizer. The solvents were evaporated and the residue was chromatographed on a silica gel column eluted with 0-5 % MeOH/DCM obtaining compound 5 as off white solid (120 mg, 26 %). 1H NMR (400 MHz, DMSOd6) 5 12.66 (bs, IH, NH), 10.37 (s, IH, NH), 9.79 (s, IH, NH), 7.71 (bs, 3H; Ar-H), 7.51 (d, J = 8.4 Hz, IH, Ar-H), 6.07-6.01 (bs, IH, Ar-H), 3.70 (bs, 4H, 2CH2), 2.33 (m, 4H, 2CH2), 2.20 (s, 3H, CH3), 1.85-1.78 (m, IH, CH), 1.84-1.82 (m, 4H, Ar-H); ESI-MS: calculated for (C25H27N9OS2) 517, found 518 [M+H]+. HPLC: retention time: 17.10 min. purity: 100%.

The synthetic route of 96799-02-9 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 25016-20-0

Step 1: Preparation ofmethyl 1-methyl-JH-pyrazole-3-carboxylate. To a solution of i-methyl1H-pyrazole-3-carboxylic acid (504 mg, 4 mmol) in MeOH (5 mL) was added SOC12 (1.4 mL, 20 mmol) at 0C. The mixture was stirred at r.t overnight then concentrated under reduced pressure. The residue was dissolved in EtOAc, washed withsatd. aq. NaHCO3and concentrated to afford methyl 1 -methyl-1H-pyrazole-3-carboxylate.LC-MS: m/z 141 (M+H).

The synthetic route of 1-Methyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

Electric Literature of 1780-72-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1780-72-9 as follows.

General procedure: To a mixture of 1-aryl-3-ethoxy-2-(phenylsulfonyl)prop-2-en-1-one 3refPreviewPlaceHolder[28] (10 mmol) and appropriate aminopyrazole derivative 2 (10 mmol) in absolute EtOH (25 mL) were added few drops of piperidine and the reaction mixture was refluxed for 1 h, then left to cool. The formed solid product was filtered off, washed with ethanol and recrystallized from EtOH/DMF to afford products identical in all respects (mp, mixed mp and spectra) with those obtained by refPreviewPlaceHolderMethod A above.

According to the analysis of related databases, 1780-72-9, the application of this compound in the production field has become more and more popular.