Reference of 1780-72-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1780-72-9 name is 4-Bromo-5-methyl-1H-pyrazol-3-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[Pt(bpma)(pzBr)]Cl2·2H2O was synthesized with reaction of the methanolic solution of pzBr (0.0022 g,12.4 muM, 4 cm3) and aqueous solution of [Pt(bpma)Cl]Cl (0.006 g, 12.4 muM, 5 cm3) mixed in molar ratio1 : 1. pH of the colorless solution was maintained at 7 because [Pt(bpma)Cl]Cl could be converted intothe unreactive hydroxo species at higher pH. The mixture was stirred for 24 h and after two days the colorless crystal product was filtered off and washed with methanol. The crystals of the complex aremechanically separated for X-ray analysis. Anal Calcd for C16H23Cl2BrN6O2Pt (%) FW = 677.28: C, 28.37; H,3.42; N, 12.41. Found: C, 28.29; H, 3.48; N, 12.10; UV-vis: lambdamax (nm) = 245; 271, 1H NMR, 200 MHz, D2O: delta(ppm): 1.89 (s, 3H, CH3-pzBr); 3.76 (s, 4H, CH2-bpma); 7.42 (t, 2H, J = 6.8 Hz, H4-bpma); 7.68 (d, 2H, J = 8 Hz,H3-bpma); 7.74 (d, 2H, J = 6.8 Hz, H6-bpma), 8.18 (t, 2H, J = 8 Hz, H5-bpma). IR (KBr, 4000-300 cm-1):3500-3200 (N-H stretch, O-H stretch); 3150-2850 (-CH stretch,=CH stretch); 1630 (C=N stretch); 787(N-H wagging) (figures 1S-3S, supplementary material).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-5-methyl-1H-pyrazol-3-amine, and friends who are interested can also refer to it.