Category: 96799-02-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-(Furan-2-yl)-1H-pyrazol-3-amine

General procedure: A mixture of aldehyde (1.5 mmol), amine (3 mmol) and p-toluenesulphonic acid monohydrate (0.011 g, 0.06 mmol) in ethanol (10 mL) was heated to reflux for 2 h. After cooling, the precipitate was filtered off, washed with a little cold ethanol and dried in vacuo over anhydrous CaCl2.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 96799-02-9.

Reference:
Article; Markovic, Violeta; Eric, Slavica; Stanojkovic, Tatjana; Gligorijevic, Nevenka; Aranelovic, Sandra; Todorovic, Nina; Trifunovic, Snezana; Manojlovic, Nedeljko; Jelic, Ratomir; Joksovic, Milan D.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 15; (2011); p. 4416 – 4421;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Computed Properties of C7H7N3O

A solution of 3-amino-5-(2-furyl)pyrazole (162 mg, 1.09 mmol) and DIPEA (0.19 mL, 1.09 mmol) in THF (5 mL) was added dropwise to a solution of cyanuric chloride (200 mg, 1.09 mmol) in THF (16.0 mL) at 0 0C. The reaction mixture was stirred at 0 C to room temperature for 2 hours. Then, 1-metyl piperazine (0.12 mL, 1.09 mmol) and DlPEA (0.19 mL, 1.30 mmol) were added to the mixture. The mixture was allowed to stir at room temperature for 3 hours. The solids were filtered off to give compound 11 as white solid (1 10 mg, 14 %). %). 1H NMR (400 MHz, DMSOd6) delta 12.92 (s, IH, NH), 10.38 (s, IH, NH), 7.76 (s, IH, Ar-H), 6.816.61 (m, 3H, Ar-H), 3.77-3.72 (m, 4H, 2CH2), 2.38-2.35 (m, 4H, 2CH2), 2.21 (2, 3H, CH3); ESI-MS: calculated for (C15Hi7ClN8O) 360, found 361 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; NALLAN, Laxman; POLAT, Tulay; HO, David; DESAI, Neil, P.; WO2010/144550; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 96799-02-9,Some common heterocyclic compound, 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, molecular formula is C7H7N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 18To a solution of cyanuric chloride (230 mg, 1.25 mmol) in THF (16 mL) was added 4- fluorophenyl-2-ethylamine (0.16 mL, 1.25 mmol) and DIPEA (0. 20 mL, 1.25 mmol) at 0 C. The reaction mixture was let to stir at 0 C to room temperature for 2h. 3-amino-5-(2- furyl)pyrazole (187 mg, 1.25 mmol) and DIPEA (0.20 mL, 1.25 mmol) were added to the above mixture and the resulting mixture was heated with microwave initiator at 150 C for 10 minutes. 1 -methylpiperazine (0.28 mL, 2.50 mmol) and DIPEA (0.44 mL, 2.50 mmol) were added to the mixture and the mixture was heated with microwave initiator at 60 C for 10 minutes. Saturated NaHCO3 in water was added and the mixture was extracted by ethyl acetate (3 x 50 mL). The combined organic was washed by brine, dried over sodium sulfate and concentrated. The residue was chromatographed on a silica gel column eluted with 0-5 % MeOH/DCM afforded 18 as white solid (65 mg, 11 %). 1HNMR (400 MHz, DMSO-d6,80C) delta 12.48 (bs, 1H, NH), 9.52 (bs, 1Eta, NH), 8.55 (bs, 1Eta, NH), 7.71-5.96 (m, 8Eta, Ar-H), 5.12 (bs, 1Eta, CH), 3.67 (b, 4Eta, 2CH2), 2.30 (bs, 4Eta, 2CH2), 2.21 (s, 3Eta, CH3), 1.47 (s, 3Eta, CH3), 1.45 (s, 3Eta, CH3); ESI-MS: calcd for (C23Eta26FN9O) 463, found 464 [M+H]+. HPLC: retention time: 16.82 min. purity: 95%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-(Furan-2-yl)-1H-pyrazol-3-amine, its application will become more common.

Reference:
Patent; ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; HO, David; NALLAN, Laxman; POLAT, Tulay; SUN, Xiaowen; DESAI, Neil; WO2010/144394; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 96799-02-9, These common heterocyclic compound, 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 21 To a solution of cyanuric chloride (230 mg, 1.25 mmol) in THF (16 mL) was added (S)- l-(4-fluorophenyl)ethylamine (0.16 mL, 1.25 mmol) and DIPEA (0. 20 mL, 1.25 mmol) at 0 C. The reaction mixture was let to stir at 0 C to room temperature for 2h. 3-amino- 5-(2-furyl)pyrazole (187 mg, 1.25 mmol) and DIPEA (0.20 mL, 1.25 mmol) were added to the above mixture and the resulting mixture was heated with microwave initiator at 150 C for 10 minutes. 1-methylpiperazine (0.28 mL, 2.50 mmol) and DIPEA (0.44 mL, 2.50 mmol) were added to the mixture and the mixture was heated with microwave initiator at 60 C for 10 minutes. Saturated NaHCO3 in water was added and the mixture was extracted by ethyl acetate (3 x 50 mL). The combined organic was washed by brine, dried over sodium sulfate and concentrated. The residue was chromatographed on a silica gel column eluted with 0-5 % MeOH/DCM afforded 21 as light brown solid (52 mg, 9 %). 1H NMR (400 MHz, DMSO-d6,80C) delta 12.46 (bs, 1H, NH), 9.52 (bs, 1Eta, NH), 8.55 (bs, 1Eta, NH), 7.63-6.04 (m, 8Eta, Ar-H), 5.12 (bs, 1Eta, CH), 3.67 (bs, 4Eta, 2CH2), 2.30 (bs, 4Eta, 2CH2), 2.21 (s, 3Eta, CH3), 1.47 (s, 3Eta, CH3), 1.45 (s, 3Eta, CH3); ESI-MS: calcd for (C23Eta26FN9O) 463, found 464 [M+H]+. HPLC: retention time: 17.10 min. purity: 99%.

The synthetic route of 96799-02-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; HO, David; NALLAN, Laxman; POLAT, Tulay; SUN, Xiaowen; DESAI, Neil; WO2010/144394; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 96799-02-9, Recommanded Product: 96799-02-9

Example 6 8-(4-Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid (5-furan-2-yl-1H-pyrazol-3-yl)-amide This compound was prepared from 8-(4Methyl-piperazin-1-yl)-4-oxo-4H-chromene-2-carboxylic acid hydrochloride (Reference Example 1) and commercially available 5-furan-2-yl-1H-pyrazol-3-ylamine (Maybridge) as prepared in example 1, yielding a yellow solid. MS (M+H) m/z=420.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(Furan-2-yl)-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chapdelaine, Marc; Davenport, Timothy; Haeberlein, Markus; Horchler, Carey; McCauley, John; Pierson, Edward; Sohn, Daniel; US2004/110745; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 96799-02-9, A common heterocyclic compound, 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, molecular formula is C7H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

6- amino-benzothiazole (188 mg, 1.25 mmol) and DIPEA (0. 22 mL, 1.25 mmol) were added to a solution of cyanuric chloride (230 mg, 1.25 mmol) in THF (16 mL) at 0 0C. The reaction mixture was stirred at 0 0C to room temperature for 2 hours. 3-amino-5-(2- furyl) pyrazole (187 mg, 1.25 mmol) and DIPEA (0.22 mL, 1.25 mmol) were added to the above mixture and the resulting mixture was heated with microwave initiator at 150 C for 10 minutes. 1 -methylpiperazine (0.28 mL, 2.50 mmol) and DIPEA (0.44 mL, 2.50 mmol) were added to the mixture and the mixture was heated with microwave initiator at 60 0C for 10 minutes. Saturated NaHCO3 in water was added and the mixture was extracted by ethyl acetate (3 x 50 mL). The combined organic was washed by brine, dried over sodium sulfate and concentrated. The residue was chromatographed on a silica gel column and eluted with 0- 5 % MeOH/DCM which afforded compound 37 as a white solid (200 mg, 34%). 1H NMR (400 MHz, DMSO-d6) delta 12.86 (bs, IH, NH), 10.99 (bs, IH, NH), 9.61 (bs, IH, NH), 9.21 – 6.59 (m, 8H, Ar-H), 4.68 (bs, 2H, CH2), 3.43 (bs, 2H, CH2), 3.09 (bs, 4H, 2CH2), 2.76 (s, 3H, CH3); ESI-MS: calculated for (C22H22Ni0OS) 474, found 475 [M+H]+. HPLC: retention time: 14.52 min. purity: 97%.

The synthetic route of 96799-02-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; NALLAN, Laxman; POLAT, Tulay; HO, David; DESAI, Neil, P.; WO2010/144550; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 5-(Furan-2-yl)-1H-pyrazol-3-amine

Synthesis of 2-(5-Amino-3-furan-2-yl-pyrazol-1-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone Protocol T was followed using 3-Furan-2-yl-2H-pyrazol-5-ylamine, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using 100% ethyl acetate afforded the title compound as a white solid. 1H NMR (400 MHz, CD6CO) delta 7.48-7.52 (m, 1H), 6.98-7.06 (m, 2H), 6.52-6.56 (m, 2H), 6.44-6.48 (m, 2H), 5.74 (s, 1H), 4.98 (s, 2H), 3.68-3.88 (m, 4H), 3.12-3.24 (m, 4H). MS (ES) M+H) expected=369.4, found 370.1.

According to the analysis of related databases, 96799-02-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ChemoCentryx, Inc.; US2004/162282; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 96799-02-9 as follows. Quality Control of 5-(Furan-2-yl)-1H-pyrazol-3-amine

EXAMPLE 50 6-Fluoro-3-[(5-furan-2-yl-1H-pyrazol-3-ylamino)-methylene]-1,3-dihydro-indol-2-one The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 5-furan-2-yl-1H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one (0.033 gms.) is reacted with 0.061 gms. 5-furan-2-yl-1H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (0.88 mL) to afford the named compound in the amount of 0.0263 gms.

According to the analysis of related databases, 96799-02-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Allergan, Inc.; US6559173; (2003); B1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H7N3O

Example 15To a solution of cyanuric chloride (300 mg, 1.63 mmol) in THF (16 mL) was added benzylmercaptan (0.19 mL, 1.63 mmol) and DIPEA (0.21 mL, 1.63 mmol) at 0 C. The reaction mixture was let to stir at 0 C to room temperature for 2h. 3-amino-5-(2- furyl)pyrazole (243 mg, 1.63 mmol) and DIPEA (0.21 mL, 1.63 mmol) were added to the above mixture and the resulting mixture was heated with microwave initiator at 150 C for 10 minutes. 1 -methylpiperazine (0.36 mL, 3.26 mmol) and DIPEA (0.57 mL, 3.26 mmol) were added to the mixture and the mixture was heated with microwave initiator at 60 C for 10 minutes. Saturated NaHCO3 in water was added and the mixture was extracted by ethyl acetate (3 x 50 mL). The combined organic was washed by brine, dried over sodium sulfate and concentrated. The residue was chromatographed on a silica gel column eluted with 0-5 % MeOH/DCM afforded 15 as white solid (250 mg, 34 %). 1H NMR (400 MHz, DMSOd6) delta 12.83 (s, 1H, NH), 9.92 (bs, 1Eta, NH), 7.74-6.59 (m, 9Eta, Ar-H), 4.34 (s, 2Eta, CH2), 3.75 (s, 4Eta, 2CH2), 2.34 (s, 4Eta, 2CH2), 2.29 (s, 3Eta, CH3); ESI-MS: calcd for (C22Eta24N8OS) 448, found 449 [M+H]+. HPLC: retention time: 20.34 min. purity: 99%.

According to the analysis of related databases, 96799-02-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; HO, David; NALLAN, Laxman; POLAT, Tulay; SUN, Xiaowen; DESAI, Neil; WO2010/144394; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Product Details of 96799-02-9

To a solution of compound 2 (300 mg, 0.88 mmol) in THF (5 mL) a solution of 3- amino-5-92-furyl)pyrazole (105 mg, 0.70 mmol) and DIPEA (0.16 mL, 0.88 mmol) was added in 10-20 mL microwave vial. Vial was sealed with a cap and the mixture was allowed to stir at 150 0C for 5 minutes in the microwave synthesizer. Next, 1 -methyl piperazine (0.15 mL, 1.32 mmol) and DIPEA (0.23 mL, 1.32 mmol) were added to the above mixture and allowed to stir at 60 0C for 10 min. in the microwave synthesizer. The solvents were evaporated and the residue was chromatographed on a silica gel column eluted with 0-5 % MeOH/DCM obtaining compound 5 as off white solid (120 mg, 26 %). 1H NMR (400 MHz, DMSOd6) 5 12.66 (bs, IH, NH), 10.37 (s, IH, NH), 9.79 (s, IH, NH), 7.71 (bs, 3H; Ar-H), 7.51 (d, J = 8.4 Hz, IH, Ar-H), 6.07-6.01 (bs, IH, Ar-H), 3.70 (bs, 4H, 2CH2), 2.33 (m, 4H, 2CH2), 2.20 (s, 3H, CH3), 1.85-1.78 (m, IH, CH), 1.84-1.82 (m, 4H, Ar-H); ESI-MS: calculated for (C25H27N9OS2) 517, found 518 [M+H]+. HPLC: retention time: 17.10 min. purity: 100%.

The synthetic route of 96799-02-9 has been constantly updated, and we look forward to future research findings.