Tag: M.W=0-100

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1820-80-0, name is 1H-Pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1H-Pyrazol-3-amine

To a stirred suspension of 118 (2.00g, 24.O7mmol) in concentrated HC1 (32mL) was added a solution ofNaNO2 (3.32g. 48.i4mmoi) in water (5mL) over 5 minutes at 0C. To the resulting orange reaction mixture was added a solution of KI (9.99g, 60 iSmmol) in water (l0mL) over 10 minutes. The reaction mixture was stirred at 0C for 30 minutes and then kept at 28C for another 2 hours, TLC showed the reaction was complete, then, solvent THF (3OmL) was added,followed by water (3OmL). The aqueous mixture was extracted with EtOAc (3 x8OmL) and the combined organic extracts were washed with Na2S2O3 (2 x4OmL), dried over Na2SO4, filtered and concentrated in vacuum to afford product 180 (200 g, crude), the crude product was used directly for the next step without purification.LCMS: m/z, i94.9M+H)??.

According to the analysis of related databases, 1820-80-0, the application of this compound in the production field has become more and more popular.

Electric Literature of 288-13-1, The chemical industry reduces the impact on the environment during synthesis 288-13-1, name is 1H-Pyrazole, I believe this compound will play a more active role in future production and life.

General procedure: General procedure: iodobenzene (1.0mmol), pyrazole (1.5 mmol), LiOH (2.0 mmol), TBAB(0.2 mmol), active Cu (0.1 mmol) and 2 mL H2O were added to a 10 mL flask. The mixture was heated in an oil bath at 120?. When the reaction completed, the resulting mixture was cooled to room temperature and the product was extracted by ethyl acetate (10 mL¡Á3). The combine dextracts were washed by brine (15 mL) , dried over MgSO4 and evaporated under reduced pressure. Further purification by silica gel column chromatography (5:1 petroleum ether/ethylacetate) give 1-phenyl-1H-pyrazole (2a, 0.126 g, 88%) as a Colorless liquid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole, other downstream synthetic routes, hurry up and to see.

132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 132712-71-1

General procedure: Dichloromethane (10 mL) was taken in a round-bottomed flask,into which 1.0 equivalent (1 mmol) of triethylamine and pyrazolonewere poured. The mixture was stirred for 2 min without heating. To this mixture, 1.0 equivalent of corresponding presynthesized benzylidene from malononitrile was added. Then the mixture was agitated for 25-30 min. The reaction was observed by TLC. The desired products appeared as precipitates. The precipitates were washed with water to remove the unreacted pyrazolone to obtain pure products. Melting points were recordedfor crystalline substances.

The synthetic route of 132712-71-1 has been constantly updated, and we look forward to future research findings.

Electric Literature of 2820-37-3, A common heterocyclic compound, 2820-37-3, name is 3,4-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 63 N,N,alpha,3,4-Pentamethylpyrazole-1-acetamide and N,N,alpha,4,5-pentamethylpyrazole-1-acetamide Following the procedure of Example 36, Part B, but substituting 3,4-dimethylpyrazole for 4-bromo-3-isopropylpyrazole, there was prepared N,N,alpha,3,4-pentamethylpyrazole-1-acetamide having a boiling point at 77 C. at 0.03 mm Hg.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1120-82-7

1,4-bis(pyrazol-1-ylmethyl)-7-ethyl-1,4,7-triazacyclononane (L3) The ligand can be synthesised by heating 20 mmol Et-tacn (3.10 g), 40 mmol pyrazolylmethanol (3.92) (ref W. Driessen, Recl. Trav., Chim. Pays-Bas, 101, 441, 1982) and 0.4 g LiOH in 50 ml acetonitril for 20 hours under back-flow and argon atmosphere. The solution is filtered and the solvent is rotated off. The product has the form of a bright yellow oil. Yield: 6.3 g (80%). 1H-NMR (CDCl3- 400 MHz; 300K): 7.43 (d; 4H); 6.21 (s; 2H); 4.93 (s, 4H); 2.83(m; 8H); 2.62 (m; 4H); 2.53 (q; 2H); 0.95 (t, 3H); 13C-NMR: 139.0; 129.3; 125.9; 72.6; 54.3; 53.5; 52.7; 51.7; 12.3 ppm. MS (EI): m/z: 317.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1120-82-7.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 930-36-9, name is 1-Methylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Methylpyrazole

To a mixture of 1-methyl-1H-pyrazole (16.4 g, 0.2 mol, 1.0 eq) in dry THF (150 mL) was added n-BuLi (2.5 M in hexane, 96 mL, 0.24 mol, 1.2 eq) at -78 C. under nitrogen atmosphere. The mixture was stirred at -78 C. for 1 h. Then DMF (30.8 mL, 0.4 mol, 2.0 eq) was added dropwise and the mixture was stirred for 1 h. TLC analysis of the reaction mixture showed full conversion to the desired product. The reaction was quenched with a saturated aqueous solution of NH4Cl and extracted with EA (3¡Á500 mL). The organic layer was washed with brine and water, dried over Na2SO4 and concentrated under vacuum. The residue was purified by column chromatography on a silica gel to give compound OI-5a (12.7 g, 58%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 930-36-9.

Electric Literature of 67-51-6,Some common heterocyclic compound, 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

15.6 g (0.088 mol) of the above intermediate crude product was dissolved in 500 mL of acetone and 17.6 g (0.132 mol) of NIS was added.The reaction solution was placed in ultrasonic wave for 8 h, the temperature should not exceed 25-30 .The reaction solution was filtered and the filtrate was concentrated and the resulting residue was passed through a short silica gel column,Dichloromethane as eluent. And concentrated under reduced pressure to give an orange liquid (16.85 g)Is a crude product of 4-iodo-3,5-dimethyl-lH-pyrazole.

The synthetic route of 67-51-6 has been constantly updated, and we look forward to future research findings.

Related Products of 14884-01-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14884-01-6, name is 4-Methoxy-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of Al (150 mg, 0.339 mmol) in acetone (3 mL) was added 4-methoxy-lH- pyrazole (49.8 mg, 0.508 mmol), followed by K2CO3 (93.7 mg, 0.678 mmol). The resulting reaction mixture was stirred at 40C for 16 hrs. To the mixture was added water (10 mL) and extracted with EtOAc (3 x 8 mL). The combined organic phase was concentrated to give a residue, which was purified by preparative HPLC to give compound 37 (10 mg, 7%), [381] 37: 1H NMR (400 MHz, CDCI3) delta 7.28 (s, IH), 7.09 (s, IH), 4.87-4.75 (m, 2H), 3.76 (s, 3H), 3.47-3.31 (m, 2H), 3.28 (s, 3H), 2.56 (t, = 8.8 Hz, IH), 2.17-2.01 (m, 4H), 1.71-1.42 (m, 8H), 1.41-0.92 (m, 12H), 0.91-0.84 (m, 2H), 0.69 (s, 3H). LCMS Rt = 1.256 min in 2 min chromatography, MS ESI calcd. for C27H43N204 [M+H]+ 459, found 459.

The synthetic route of 4-Methoxy-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35277-02-2, name is 4-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C3H3FN2

To a solution of C30 (222 mg, 0.539 mmol) in N,N-dimethylformamide (3 mL) were added cesium carbonate (528 mg, 1.62 mmol) and 4-fluoro-1H-pyrazole (69.6 mg, 0.809 mmol). The reaction mixture was stirred overnight at room temperature, and then at 50 C. for 3 hours, whereupon it was diluted with water and extracted with ethyl acetate (3*50 mL). The combined organic layers were dried over magnesium sulfate, filtered, concentrated in vacuo, and purified via chromatography on silica gel (Gradient: 10% to 65% ethyl acetate in heptane) to provide the product as a colorless oil. Yield: 148 mg, 0.455 mmol, 84%. LCMS m/z 326.4 [M+H]+. 1H NMR (400 MHz, CDCl3) delta 7.37 (d, J=5.1 Hz, 1H), 7.32 (d, J=4.3 Hz, 1H), 4.88-4.80 (m, 1H), 4.15 (dd, half of ABX pattern, J=10.0, 6.0 Hz, 1H), 4.10 (dd, half of ABX pattern, J=10.2, 4.7 Hz, 1H), 3.68-3.56 (br m, 2H), 3.37-3.26 (m, 2H), 2.28 (dd, half of ABX pattern, J=13.7, 8.6 Hz, 1H), 2.17 (dd, half of ABX pattern, J=13.5, 5.3 Hz, 1H), 1.80-1.59 (m, 3H), 1.59-1.49 (m, 1H), 1.44 (s, 9H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 35277-02-2.

Synthetic Route of 67-51-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 67-51-6 name is 3,5-Dimethyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 1-benzyl-4-chloro-3,5-dimethyl-1H-pyrazole. To a 16 mL vial containing 1-benzyl-3,5-dimethyl-1H-pyrazole (196 mg, 1.05 mmol) and a magnetic stir bar, 0.7 mL of water and 0.3 mL of ethyl acetate was added. Next, NaCl (123 mg, 2 mmol) was added and the vial was placed in a room temperature water bath to control exotherms. Finally, Oxone (322 mg, 0.52 mmol or 1.05 mmol KHSO5) was added and the vial was capped. The reaction proceeded with continuous and vigorous stirring until no starting material remained as indicated by TLC (1 h). The remaining oxidants were reduced with solid sodium bisulfite until starch iodide paper tested negative. Water (5 mL) was added and the mixture was extracted with 1:1 hexanes/diethyl ether (3 x 5 mL). The combined organic fractions were dried (MgSO4) and concentrated to yield crude product that was purified by flash chromatography (14 x 1 cm), 9:1 hexane/ethyl acetate eluent. Pure 1-benzyl-4-chloro-3,5-dimethyl-1H-pyrazole was obtained as a pale yellow oil (215 mg, 93% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dimethyl-1H-pyrazole, and friends who are interested can also refer to it.