Electric Literature of 67-51-6,Some common heterocyclic compound, 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
15.6 g (0.088 mol) of the above intermediate crude product was dissolved in 500 mL of acetone and 17.6 g (0.132 mol) of NIS was added.The reaction solution was placed in ultrasonic wave for 8 h, the temperature should not exceed 25-30 .The reaction solution was filtered and the filtrate was concentrated and the resulting residue was passed through a short silica gel column,Dichloromethane as eluent. And concentrated under reduced pressure to give an orange liquid (16.85 g)Is a crude product of 4-iodo-3,5-dimethyl-lH-pyrazole.
The synthetic route of 67-51-6 has been constantly updated, and we look forward to future research findings.