Category: 2820-37-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2820-37-3, name is 3,4-Dimethyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H8N2

145 Kg of 3,4-dimethylpyrazole obtained after post-treatment of reaction zone B was dissolved in 200 Kg of ethanol and 110 Kg of water.After the mixed solution is placed in the corresponding storage tank, the reaction zone C of the microchannel reactor is preheated to about 45 C, wherein the reaction CThe zone is composed of 3 microchannel reaction tablets with a liquid holding capacity of 200 mL, wherein the ethanol solution of 3,4-methylpyrazole and 174 Kg areThe amount of phosphoric acid with a fraction of 85% is 2.50 L/min and 1.02 L/min, the residence time is about 10 s, cooling, crystallization, overFiltration, drying to obtain about 281.2Kg of white powdery solid, namely 3,4-dimethylpyrazole phosphate, the yield is 95.9%, the purity is96.2% (HPLC).

The synthetic route of 2820-37-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sinochem Agricultural (Linyi) Research And Development Center Co., Ltd.; Sun Yingxiang; Wei Yanqing; Liu Xiaobo; Zhang Xixing; (17 pag.)CN109574935; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2820-37-3, name is 3,4-Dimethyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Safety of 3,4-Dimethyl-1H-pyrazole

5 will weigh 100mg, 0.23mmolThe pentachloroene was placed in a 25 mL two-necked flask.Drum nitrogen evacuation was repeated 3 times to obtain an anhydrous and oxygen-free reaction system.Then 7 mL of N,N-dimethylformamide was added as a reaction solvent.The reaction device is then placed in a sonicator at room temperature for 2hThe decachloromaleene is fully dispersed in N,N-dimethylformamide,At the same time weighed 68mg,2.84mmol, 20 equivalent mass fraction of 60%The sodium hydride was placed in a 25 mL two-necked flask.Drum nitrogen evacuation repeat 3In the same manner, an anhydrous and oxygen-free reaction system was obtained.Then 8 mL of N,N-dimethylformamide was added as a reaction solvent.Stir 0.5 h so that sodium hydride is fully dispersed in the solvent.Then use a syringe to extract 453mg,20 equivalents of 3,4-dimethylpyrazole are slowly injected into dispersed sodium hydride N,N-dimethylformamide.Then there are a lot of bubbles in the solution,Stirred for 0.5 h to give a clear orange solution.Then slowly add this clear orange solutionAfter ten bowl chloride ultrasound ene reaction flask,It can be seen that the color of the solution quickly turns dark green and slowly approaches blackThe reaction system was reacted overnight at 25C.After the reaction is over,Add a small amount of water slowly to quench the reaction.Then it is extracted with dichloromethane and washed continuously until the color in the aqueous phase is colorless.Then all the organic phases were collected, spin-dried and passed through a silica gel column.The light yellow ribbon is the target molecule3,4-Dimethylpyrazoleene bowlene compound, 4.4 mg,The yield was 30%

The synthetic route of 2820-37-3 has been constantly updated, and we look forward to future research findings.

Electric Literature of 2820-37-3, A common heterocyclic compound, 2820-37-3, name is 3,4-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 63 N,N,alpha,3,4-Pentamethylpyrazole-1-acetamide and N,N,alpha,4,5-pentamethylpyrazole-1-acetamide Following the procedure of Example 36, Part B, but substituting 3,4-dimethylpyrazole for 4-bromo-3-isopropylpyrazole, there was prepared N,N,alpha,3,4-pentamethylpyrazole-1-acetamide having a boiling point at 77 C. at 0.03 mm Hg.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2820-37-3 as follows. 2820-37-3

To a solution of crude reactant (249.5 mg, 0.629 mmol, theoretical amount) in anhydrous THF (5 mL) was added 3.4-dimethyl-lH-pyrazole (120.7 mg, 1.256 mmol) followed by potassium carbonate (173.6 mg, 1.256 mmol). The solution was stirred at 25 C overnight then the solution was diluted with ethyl acetate (200 mL). The resulting solution was washed with brine (2x100mL), dried over magnesium sulfate and concentrated in vacuo. The crude product was purified by silica gel chromatography (petroleum ether/ ethyl acetate =1 :3) to afford product (56 mg, 0.136 mmol, Yield=22% (2 steps)) as white solid. 1HNMR (400 MHz, CDC13) 5(ppm): 7.08 (1H, s), 4.77 (1H, AB), 4.76 (1H, AB), 2.55 (1H, t), 2.18 (3H, s), 1.00-2.20 (24H, m).0.67 (3H, s). LCMS: rt = 2.41 mm, m/z = 413.2 [M+H]+

According to the analysis of related databases, 2820-37-3, the application of this compound in the production field has become more and more popular.