Category: 1120-82-7

1120-82-7, Adding a certain compound to certain chemical reactions, such as: 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1120-82-7.

General procedure: The target pyrazoly compounds (Scheme 2), were preparedin one step by condensation of one equivalent of (3,5-dimethyl-1H-pyrazol-1-yl) methanol ((1H-pyrazol-1-yl)methanol) with one equivalent of an appropriate amine in20 mL of acetonitrile (CH3CN) as solvent. All reactionswere carried out at reflux for 4 h. The liquid residue is driedover MgSO4, filtered and concentrated in vacuum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-1-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Abrigach; Karzazi; Benabbes; El Youbi; Khoutoul; Taibi; Karzazi; Benchat; Bouakka; Saalaoui; Touzani; Medicinal Chemistry Research; vol. 26; 8; (2017); p. 1784 – 1795;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 1120-82-7, The chemical industry reduces the impact on the environment during synthesis 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, I believe this compound will play a more active role in future production and life.

To a Schlenk tube was added Cul (9.5 mg), Pd(Ph3P)2Cl2 (35 mg), compound A (1085) (188 mg, 0.5 mmol), TMS acetylene (98 mg, 1.0 mmol), DMF (2 mL), and Et3N (0.5 mL). The reaction mixture was heated at 80 C for 12 hours. The reaction mixture was cooled and treated with EtOAc and brine. The organic layer was separated, dried, and evaporated. The residue was chromatographed on silica gel to give the TMS intermediate. The TMS intermediate was treated with TBAF (0.6 mmol) in 2 mL dry THF for 15 min. The residue was chromatographed on silica gel to give compound C (115 mg, 17% yield). (1086) [0621] To a solution of (lH-pyrazol-l-yl)methanol (196 mg, 2 mmol) in DCM (2 mL) was added methanesulfonyl chloride (4 mmol). The mixture was stirred at 0 C for 10 minutes then Et3N (6 mmol) was slowly added. After stirring at r.t. for 30 min, all volatiles were removed. 3-(4-Hydroxy-l-oxoisoindolin-2-yl)piperidine-2,6-dione (520 mg, 2 mmol), KHC03 (400 mg, 4 mmol), KI (10 mg) and 4 mL CH3CN were added to the residue. The mixture was heated at reflux overnight. The residue was chromatographed on silica gel to give compound D (210 mg, 31% yield). (1087) [0622] To a solution of compound D (210 mg, 0.62 mmol) in acetic acid (4 mL) was added NIS (321 mg, 0.75 mmol). The reaction was stirred for 1 h prior to being concentrated. The residue was purified by HPLC to afford compound E (156 mg, 54%). ESI-MS: 481.05. (1088) [0623] To a Schlenk tube was added Cul (2 mg), Pd(Ph3P)2Cl2 (4 mg), compound C (1089) (20 mg, 0.06 mmol), compound E (28 mg, 0.06 mmol), DMF (2 mL), and Et3N (0.5 mL). The reaction mixture was heated at 80 C for 12 hours. The reaction mixture was cooled and treated with EtOAc and brine. The organic layer was separated, dried, and evaporated. The residue was subjected to HPLC purification to afford Cpd. No. 82 (25 mg, 64% yield). ESI-MS: 674.05.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-1-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; HU, Yang; QIN, Chong; XU, Fuming; HU, Jiantao; ZHOU, Bing; CHEN, Zhou; FERNANDEZ-SALAS, Ester; BAI, Longchuan; McEACHERN, Donna; (198 pag.)WO2018/52945; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 1120-82-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1120-82-7 as follows.

first,4-bromobenzenamine (3.44 g,0.0200 mol) was dissolved in a CH2Cl2 solvent (30.0 mL). 1H-1-pyrazolyl-1-methanol (3.92 g, 0.0400 mol) was dissolved in a CH2Cl2 solvent (20.0 mL) and added. The reaction was carried out at room temperature for 24 hours, the water was removed by solution reaction with MgSO4,The solution was removed by pressure. A green solid was obtained after distillation under reduced pressure. (5.89 g, 88.7%).

According to the analysis of related databases, 1120-82-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kyungpook National University Industry-Academic Cooperation Foundation.; Lee, Hyo Sun; Jung, Jong Hwa; Choe, Sung Hey; Cho, Jae Won; (24 pag.)KR2017/51867; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 1120-82-7,Some common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The three compounds were prepared by the same procedure analogue for L1. L1 was prepared by a similar procedure asdescribed in the literature [21]. The CH2Cl2 solution (10.0 mL) ofpyrimidinamine (1.15 g, 12.09 mmol) was added to the CH2Cl2 solution(10.0 mL) of 1H-1-pyrazolyl-1-methanol (1.86 g,12.09 mmol). The reaction solution was dried over MgSO4 afterstirring at room temperature for 4 days. The filtrate solvent, underreduced pressure, produced a transparent oil andwas recrystallizedusing a mixture of methanol with a few drops of ether. The whitecrystals obtained after 3 days were filtered and washed withmethanol (2 50 mL), followed by washing with Et2O (2 50 mL)to yield the final product (L1). 2.2.1.1. The N-((1H-pyrazol-1-yl) methyl) pyrimidin-2-amine (L1).White cristal. Yield (1.8 g, 85.3%). mp 418 K. FT-IR, cm1: 1077(CeN), 3080 (CeH, HeC]CeH), 1333 (C]N), 1380 (N]N), 1582(C]C), 3234 (NeH). UVevis (l 298 nm). 1H NMR(300 MHz,DMSO): dH 5.37 (d, 2H, CH2), 6.27 (t, 1H, CHPyr), 6.54 (t,1H, CHAr), 6.71 (t, 1H, NH), 7.47 (d, 1H, CHPy), 7.78 (d, 1H, CHPyr), 8.20(d, 1H, CHAr), 8.21 (d, 1H, CHAr). 13C NMR (75 MHz, CDCl3):dC 73.70 (CH2), 106.15 (CHPy), 110.55 (CHAr), 112.30 (CHPy), 129.85(CHPy), 139.74 (CHAr), 158.45 (CHAr), 164.02 (C).

The synthetic route of 1120-82-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Titi, Abderrahim; Messali, Mouslim; Alqurashy, Bakhet A.; Touzani, Rachid; Shiga, Takuya; Oshio, Hiroki; Fettouhi, Mohammed; Rajabi, Mehdi; Almalki, Faisal A.; Ben Hadda, Taibi; Journal of Molecular Structure; vol. 1205; (2020);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1120-82-7, Safety of (1H-Pyrazol-1-yl)methanol

General procedure: A solution of primary diamine (one equiv.) in acetonitrile(20 mL), was slowly added to a solution of 2a or 2b (fourequiv.) in 60 mL of acetonitrile. The reaction mixture was stirred under refluxed for 6h then dried over MgSO4. The solvent was removed under reduced pressure. The solid was dried using a Schlenk line.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-1-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Abrigach, Farid; Bouchal, Btissam; Riant, Olivier; Mace, Yohan; Takfaoui, Abdelilah; Radi, Smaail; Oussaid, Abdelouahad; Bellaoui, Mohammed; Touzani, Rachid; Medicinal Chemistry; vol. 12; 1; (2016); p. 83 – 89;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, A new synthetic method of this compound is introduced below., Recommanded Product: 1120-82-7

General procedure: Step 2: The reaction was performed under argon by using standard Schlenk techniques. To a cold (0?C) solution of 1-(2-hydroxymethyl)-3,5-dimethylpyrazole (1.0?g, 8?mmol) in chloroform was added dropwise thionyl chloride (1.15?mL in 15?mL of CHCl3) and the mixture was refluxed for 4?h. The precipitate (1-(2-chloromethyl)-3,5-dimethylpyrazole, 79% yield) was collected, washed with diethyl ether and dried.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Coelho, Felipe Lange; Dresch, Lucielle Codeim; Stieler, Rafael; Campo, Leandra Franciscato; Schneider, Paulo Henrique; Catalysis Communications; vol. 121; (2019); p. 19 – 26;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 1120-82-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows.

1-Fluoromethyl-lH-pyrazole Diethylaminosulfur trifluoride (4.5 mL, 34 mmol) was added dropwise to a stirred solution of pyrazol-1-yl-methanol (3.34 g, 34.1 mmol) in anhydrous THF (67 mL) at -80C. The reaction mixture was allowed to warm to room temperature and was then concentrated in vacuo. The residue was partitioned between DCM (100 mL) and water (30 mL). The pH of the aqueous layer was adjusted to 8 by the addition of solid NHCO3. The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo to give the title compound. MS (m/z): 101.0 [M+H4].

The chemical industry reduces the impact on the environment during synthesis (1H-Pyrazol-1-yl)methanol. I believe this compound will play a more active role in future production and life.

Reference:
Patent; JERINI AG; WO2008/116620; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, A new synthetic method of this compound is introduced below., Recommanded Product: 1120-82-7

Cystamine dihydrochloride (1.90 g, 8.43 mmol), N-hydroxymethylpyrazole(3.32 g, 33.9 mmol) and triethylamine (1.76 g,17.5 mmol) dissolved in dichloromethane (50 mL) were stirredfor 24 h at RT. The reaction mixture was extracted with water(30 mL) three times, after which the organic layer was dried overMgSO4 and the solvent was evaporated. This yielded L3 as a colorlessoil (3.96 g, 8.38 mmol, 99%), which was used without furtherpurification. 1H NMR (300 MHz, CD3CN, RT): d 2.65 (t, J = 7 Hz,4H, S-CH2), 2.94 (t, J = 7 Hz, 4H, S-CH2-CH2), 5.07 (s, 8H, N-CH2-Pz), 6.27 (t, J = 2 Hz, 4H, N-CH-CH), 7.47 (d, J = 1 Hz, 4H, N-CH),7.63 (d, J = 2 Hz, N-CH). 13C NMR (75 MHz, CD3CN, RT): d 37.1 (SCH2),50.2 (S-CH2-CH2), 68.9 (N-CH2-Pz), 106.6 (N-CH-CH), 130.8(N-CH), 140.1 (N-CH). ESI-MS found (calculated) for [M+Na]+ m/z495.0 (495.2); [MC3+Na]+ m/z 459.0 (459.2); [M2 C3+Na]+ m/z422.9 (423.2); [M3 C3+Na]+ m/z 387.0 (387.2); [M4 C3+Na]+m/z 350.9 (351.2). IR (neat, cm1): 3110w, 2941w, 1513m,1393m, 1251m, 1121m, 1084s, 1046s, 962m, 743vs, 653m, 614s.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 1120-82-7, A common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of primary diamine (one equiv.) in acetonitrile(20 mL), was slowly added to a solution of 2a or 2b (fourequiv.) in 60 mL of acetonitrile. The reaction mixture was stirred under refluxed for 6h then dried over MgSO4. The solvent was removed under reduced pressure. The solid was dried using a Schlenk line. Transparent oil, yield = 65.69 % .IR ( (cm-1)): 3200 -2858 (CH); 1514 (C=N); 1440 (C=C); 1280 (C-N aromatic);1143 (C-N aliphatic). 1H NMR (300 MHz, CDCl3) (ppm):7.49 – 7 .36 (m, 8H, pz(5) /pz(3)), 6.19 (t, 4H, pz, J = 3 Hz),4.85 (d, 8H, N-CH2-N, J = 3 Hz), 2.50 (t, 4H, N-CH2-CH2 ofamine, J = 3 Hz),1.57 – 1.51 (m, 2H, N-CH2-CH2 of amine).13C NMR (75 MHz, CDCl3, ppm): 139.59 (C(3)pz), 129.57(C(5)pz), 105.91(pz), 67.69(N-CH2-N), 48.85 (N-CH2-CH2 ofamine), 22.96 (N-CH2-CH2 of amine). MS [M+] (m/z): calculated394,48, found 420,12 ([M++ Na+3]).

The synthetic route of 1120-82-7 has been constantly updated, and we look forward to future research findings.

Application of 1120-82-7,Some common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: L1 was prepared by a similar procedure as described in the literature[6,49,52-54]. The CH2Cl2 solution (10.0 mL) of para-phenylenediamine(1.08 g, 0.010 mol) was added a CH2Cl2 solution(50.0 mL) of 1H-1-pyrazolyl-1-methanol (3.92 g, 0.040 mol). Thereaction solution was dried over the MgSO4 after stirring the reactionmixture at room temperature for 3 days.

The synthetic route of 1120-82-7 has been constantly updated, and we look forward to future research findings.