Related Products of 14884-01-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14884-01-6, name is 4-Methoxy-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of Al (150 mg, 0.339 mmol) in acetone (3 mL) was added 4-methoxy-lH- pyrazole (49.8 mg, 0.508 mmol), followed by K2CO3 (93.7 mg, 0.678 mmol). The resulting reaction mixture was stirred at 40C for 16 hrs. To the mixture was added water (10 mL) and extracted with EtOAc (3 x 8 mL). The combined organic phase was concentrated to give a residue, which was purified by preparative HPLC to give compound 37 (10 mg, 7%), [381] 37: 1H NMR (400 MHz, CDCI3) delta 7.28 (s, IH), 7.09 (s, IH), 4.87-4.75 (m, 2H), 3.76 (s, 3H), 3.47-3.31 (m, 2H), 3.28 (s, 3H), 2.56 (t, = 8.8 Hz, IH), 2.17-2.01 (m, 4H), 1.71-1.42 (m, 8H), 1.41-0.92 (m, 12H), 0.91-0.84 (m, 2H), 0.69 (s, 3H). LCMS Rt = 1.256 min in 2 min chromatography, MS ESI calcd. for C27H43N204 [M+H]+ 459, found 459.
The synthetic route of 4-Methoxy-1H-pyrazole has been constantly updated, and we look forward to future research findings.