The important role of (1H-Pyrazol-3-yl)methanamine

The synthetic route of 37599-58-9 has been constantly updated, and we look forward to future research findings.

Reference of 37599-58-9, A common heterocyclic compound, 37599-58-9, name is (1H-Pyrazol-3-yl)methanamine, molecular formula is C4H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Compound 1 (535 mg, 3.00 mmol, 1 equiv.)was dissolved in MeOH (3 mL). The corresponding amine(3.6 mmol) was added. The reaction mixture was stirred at RT for overnight. The solvent was removed under reduced pressure. The residue was purified by column chromatography(neutral Al2O3, EtOAc/hexane) to give pure compound 2.

The synthetic route of 37599-58-9 has been constantly updated, and we look forward to future research findings.

Analyzing the synthesis route of 4-Fluoro-1H-pyrazole

The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Related Products of 35277-02-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35277-02-2, name is 4-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4-Chloro-2-methyl-quinolin-8-ol (30 mg, 0.15 mmol) and 4-Fluoro-lH- pyrazole (Shi, Xifeng; Ishihara, Takashi; Yamanaka, Etairoki; Gupton, John T. Tetrahedron Letters 1995, 36, 1527-1530) (33 mg, 0.39 mmol) in NMP (25 muL) was stirred at 150 C for 90 min. The crude product was purified by reversed phase EtaPLC using a gradient of acetonitrile in water with 0.1 % TFA to give the title compound as the TFA salt. MS (m/z): 244.0 [M+H+]

The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

New learning discoveries about 1H-Pyrazole-4-carbaldehyde

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Pyrazole-4-carbaldehyde, its application will become more common.

Related Products of 35344-95-7,Some common heterocyclic compound, 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of the aldehyde (1 equiv.) and amine (1 equiv.) in methanol was added a catylytic amount of glacial acetic acid (a few drops) and the contents were stirred at 25 ¡ãC as outlined in reaction Scheme 1. After 4 h, the methanol was removed under reduced pressure and the crude aldimine J_a was used in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Pyrazole-4-carbaldehyde, its application will become more common.

Share a compound : 3-Methylpyrazole

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methylpyrazole, other downstream synthetic routes, hurry up and to see.

Application of 1453-58-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1453-58-3, name is 3-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1 -Benzenesulfonyl-3-methylpyrazole (T)A mixture of 3-methylpyrazole (5 g, 60.9 mmol), benzenesulfonyl chloride (8.55 mL, 67 mmol) and triethylamine (9.3 mL, 67 mmol) in acetonitrile was heated at reflux for 2 h, allowed to cool and concentrated. EtOAc (300 mL) was added and the solution was filtered and concentrated to provide a solid residue which was crystallised from EtOAc to give the title compound as an off-white powder (Yield: 7.92 g, 58 percent).1U-NMR (DMSO-d6): delta 8.35 (d, IH)5 7.97-7.94 (m, 2H), 7.78 (tt5 IH), 7.66 (t, 2H)5 6.43 (d, IH), 2.17 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methylpyrazole, other downstream synthetic routes, hurry up and to see.

The important role of (1H-Pyrazol-3-yl)methanamine

The synthetic route of 37599-58-9 has been constantly updated, and we look forward to future research findings.

Reference of 37599-58-9, A common heterocyclic compound, 37599-58-9, name is (1H-Pyrazol-3-yl)methanamine, molecular formula is C4H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Compound 1 (535 mg, 3.00 mmol, 1 equiv.)was dissolved in MeOH (3 mL). The corresponding amine(3.6 mmol) was added. The reaction mixture was stirred at RT for overnight. The solvent was removed under reduced pressure. The residue was purified by column chromatography(neutral Al2O3, EtOAc/hexane) to give pure compound 2.

The synthetic route of 37599-58-9 has been constantly updated, and we look forward to future research findings.

The important role of (1H-Pyrazol-1-yl)methanol

The synthetic route of 1120-82-7 has been constantly updated, and we look forward to future research findings.

Application of 1120-82-7,Some common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: L1 was prepared by a similar procedure as described in the literature[6,49,52-54]. The CH2Cl2 solution (10.0 mL) of para-phenylenediamine(1.08 g, 0.010 mol) was added a CH2Cl2 solution(50.0 mL) of 1H-1-pyrazolyl-1-methanol (3.92 g, 0.040 mol). Thereaction solution was dried over the MgSO4 after stirring the reactionmixture at room temperature for 3 days.

The synthetic route of 1120-82-7 has been constantly updated, and we look forward to future research findings.

Share a compound : 5-Methyl-1H-pyrazol-3-amine

The synthetic route of 5-Methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Application of 31230-17-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

The 2,4-dichloroquinazoline (1.00g, 5 . 0mmol) and 5-methyl -1H-pyrazol-3-amine (498 mg, 5 . 1mmol) dissolved in ethanol (20 ml) in, adding Et3N (1.07g, 10 . 6mmol). After adding, the reaction mixture stirring at room temperature overnight, after the reaction, the reaction mixture is concentrated under reduced pressure. Added to the resulting residue in the mixed solution of water and ethanol (10/1(v/v), 22 ml), stirring beating at room temperature 0.5 hours, filtering, the filter cake is washed with petroleum ether (20mLx3) washing, collecting filter cake to obtain the title compound as light brown solid (1.30g, 100percent)

The synthetic route of 5-Methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Discovery of 1-Methylpyrazole

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylpyrazole, other downstream synthetic routes, hurry up and to see.

Reference of 930-36-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 930-36-9, name is 1-Methylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2-Methyl-2H-pyrazole-3-boronic acid: N-methyl pyrazole (25 mL, 0.3 mol) was dissolved in 500 mL of THF. The solution was then cooled to-78C in a dry ice/isopropanol bath. Once the solution reached -78C, n-BuLi (140 mL, 0.40 mol) was added dropwise by canula. The reaction mixture was stirred at -78C for 1.5 hours. Then, triisopropyl borate (280 mL, 1.2 mol) was added to the above mixture via canula. While stirring overnight, the reaction temperature was gradually increased from -78deltaC to 0deltaC. The pH of the mixture was adjusted to 6 with IN HCI. THF was removed under reduced pressure, and the aqueous residue was extracted with EtOAc (2 x 100mL). The solid was then filtered to yield 108 g (100%) of 2-methyl-2H-pyrazole-3-boronic acid as a yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylpyrazole, other downstream synthetic routes, hurry up and to see.

The origin of a common compound about 1,5-Dimethyl-1H-pyrazole

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,5-Dimethyl-1H-pyrazole, its application will become more common.

Electric Literature of 694-31-5,Some common heterocyclic compound, 694-31-5, name is 1,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In this example, the preparation of 1,5-dimethylpyrazole hydrobromide is as follows:1.442 g (15 mmol) of 1,5-dimethylpyrazole and 3.102 g (18 mmol) of hydrobromic acid were respectively added to 100 mL of three neck Bottle, stirring 15 ~ 30h; After the reaction, the addition of water, the product was washed with ethyl acetate and dried to give a white solid 1,5-dimethylpyrazole hydrobromide ionic liquid, a yield of 70%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,5-Dimethyl-1H-pyrazole, its application will become more common.

New learning discoveries about 4-Fluoro-1H-pyrazole

According to the analysis of related databases, 35277-02-2, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35277-02-2 as follows. Safety of 4-Fluoro-1H-pyrazole

Add in 100mL round bottom flask1-bromo-N- (6-cyano-5-trifluoromethyl-pyridin-3-yl) -cyclobutanecarboxamide (0.30 g, 0.8618 mmol),4-fluoro-1H-pyrazole (0.148 g, 1.7236 mmol),Cuprous bromide dimethyl sulfide (17.7 mg, 0.08618 mmol),Triphenylphosphine (22.6 mg, 0.08618 mmol),Tripotassium phosphate (0.22 g, 1.0341 mmol),Sodium hydroxide (38 mg, 0.9480 mmol),10mL of anhydrous toluene was used as the solvent.The resulting mixture was heated to 50 C,Stir for 15 hours under argon protection.After confirming the completion of the reaction by thin layer chromatography,The reaction solution is cooled to 20 ¡À 5 ,Then add water (30 ml) and ethyl acetate (35 ml),After brief stirring, the liquid is separated,The organic phase was washed with brine (25 ml),Magnesium sulfate drying,filter,Drain the organic phase,An oily substance is obtained.Silica gel column chromatography separation (mobile phase is dichloromethane: ethyl acetate = 9: 1), purification,82 mg of yellow powder was obtained,Identified asN- (4-cyano-3-trifluoromethyl) phenyl-1- (4-fluoro-1H-pyrazol-1-yl) -cyclobutanecarboxamide.The yield is 27%.

According to the analysis of related databases, 35277-02-2, the application of this compound in the production field has become more and more popular.