Tag: M.W=0-100

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H4N2O

To a stirred solution of l,3-dibromo-5-isopropoxy-benzene (500 mg, 1.70 mmol) in toluene (15 mL) w’ere added lH-pyrazole-4-carbaldehyde (179.77 mg, 1 87 mmol) and potassium phosphate tribasic anhydrous (722.05 mg, 3.40 mmol) and the reaction was degassed with N?. for 10 minutes. Copper (1) iodide (64.78 mg, 340.16 umol, 1 1.53 uL) and N,N’-dimethyl cyclohexane- 1 ,2-diamine (48.38 mg, 340.16 umol) were added to the reaction and the reaction was again degassed for 10 minutes. The reaction was heated to 130 C for 16 hours in a sealed tube at which point TLC confirmed the formation of product. The reaction was cooled and diluted with water and EtOAc. The organics was separated and aqueous part was extracted with EtOAc. The combined organics was washed with water and brine, dried over Na2S04, and concentrated to afford crude compound that was purified by combi-flash using 20-50% EtOAc in hexane to afford l-(3-bromo-5- isopropoxy-phenyl)-lH-pyrazole-4-carbaldehyde (190 mg, 583.84 umol, 34 33% yield, 95% purity, 000) as brown solid m/z = 309.

The synthetic route of 35344-95-7 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35277-02-2 as follows. Application In Synthesis of 4-Fluoro-1H-pyrazole

In a 100mL single mouth bottle,Add 5-acetyl-2-bromopyridine (1i) (4.00 g, 20 mmol),4-fluoropyrazole (1j) (2.06 g, 24 mmol) and 50 mL of DMF,Reaction at 110 C for 7 hours,The reaction was detected by TLC until the starting point disappeared. After lowering the temperature to room temperature, it was poured into ice water to precipitate a yellow solid, which was washed with a large amount of water, filtered, and dried to obtain 3.31 g of a light yellow solid (1k) with a yield of 81%.

According to the analysis of related databases, 35277-02-2, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67-51-6, name is 3,5-Dimethyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H8N2

3,5-dimethyl-1 H-pyrazole (100 mg, 1.04 mmol) was dissolved in 1.0 mL of TFA. N-iodosuccinimide (234 mg, 1.04 mmol) was added in one portion. The reaction was strirred at rt for 1 h. LCMS showed clean reaction. Water and EtOAc were added and the phases were separated. The organic phase was washed with a aqueous saturated solution of sodium sulfite and was dried over sodium sulfate, filtered and concentrated. Afforded 230 mg of crude product (1.04 mmol, 99%) as a white solid.

The synthetic route of 67-51-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67-51-6, Safety of 3,5-Dimethyl-1H-pyrazole

EXAMPLE 5 Synthesis of 1,3,5-Trimethylpyrazole From 3,5-Dimethylpyrazole The apparatus used was the same as that described in Example 1. 24.03 g of 3,5-dimethylpyrazole, i.e. 0.25 mol, and 4.5 g of dimethyl carbonate, i.e. 0.05 mol, were introduced and the reaction medium was heated to 140 C. and this temperature was maintained throughout the reaction.The dimethyl carbonate was then introduced with a flow rate of 50 mmol/h for 8 hours.The methanol produced was distilled off as it was formed and the excess dimethyl carbonate was also distilled off to stabilize the temperature of the reaction medium at 140 C. After having introduced all the dimethyl carbonate, the reaction medium was allowed to cool to ambient temperature to obtain 15.41 g of 1,3,5-trimethylpyrazole, i.e. 0.14 mol, which corresponded to a yield of 57%. The example which follows does not form part of the invention.It was carried out for the purpose of showing that the continuous withdrawal of the methanol produced during the reaction is necessary to be able to generalize this process to several families of nitrogenous heterocycles and particularly, to nitrogenous heterocycles having a boiling point of less than 190 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, A new synthetic method of this compound is introduced below., Recommanded Product: 1120-82-7

Cystamine dihydrochloride (1.90 g, 8.43 mmol), N-hydroxymethylpyrazole(3.32 g, 33.9 mmol) and triethylamine (1.76 g,17.5 mmol) dissolved in dichloromethane (50 mL) were stirredfor 24 h at RT. The reaction mixture was extracted with water(30 mL) three times, after which the organic layer was dried overMgSO4 and the solvent was evaporated. This yielded L3 as a colorlessoil (3.96 g, 8.38 mmol, 99%), which was used without furtherpurification. 1H NMR (300 MHz, CD3CN, RT): d 2.65 (t, J = 7 Hz,4H, S-CH2), 2.94 (t, J = 7 Hz, 4H, S-CH2-CH2), 5.07 (s, 8H, N-CH2-Pz), 6.27 (t, J = 2 Hz, 4H, N-CH-CH), 7.47 (d, J = 1 Hz, 4H, N-CH),7.63 (d, J = 2 Hz, N-CH). 13C NMR (75 MHz, CD3CN, RT): d 37.1 (SCH2),50.2 (S-CH2-CH2), 68.9 (N-CH2-Pz), 106.6 (N-CH-CH), 130.8(N-CH), 140.1 (N-CH). ESI-MS found (calculated) for [M+Na]+ m/z495.0 (495.2); [MC3+Na]+ m/z 459.0 (459.2); [M2 C3+Na]+ m/z422.9 (423.2); [M3 C3+Na]+ m/z 387.0 (387.2); [M4 C3+Na]+m/z 350.9 (351.2). IR (neat, cm1): 3110w, 2941w, 1513m,1393m, 1251m, 1121m, 1084s, 1046s, 962m, 743vs, 653m, 614s.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 81945-73-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 81945-73-5 name is 1H-Pyrazol-1-ol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(General Procedure 16)4-Cyclopentyl-piperazine-1-carboxylic Acid pyrazol-1-yl Ester The title compound was prepared from 1-hydroxypyrazole and N-cyclopentylpiperazine applying the general procedure 16. The crude product was purified by preparative HPLC (water-acetonitrile-0.1% TFA) (34%, salt with TFA). 1H NMR (300 MHz; CDCl3): delta 1.45-2.01 (m, 8H), 2.70 (bs, 4H), 2.92 (bs, 1H), 3.55 (bt, 1H), 3.63 (bs, 2H), 3.77 (bs, 2H), 6.31 (t, 1H), 7.38 (dd, 1H), 7.41 (dd, 1H); HPLC-MS: m/z=265.1 (M+1); Rt=0.54 min.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazol-1-ol, and friends who are interested can also refer to it.

Electric Literature of 1120-82-7, A common heterocyclic compound, 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of primary diamine (one equiv.) in acetonitrile(20 mL), was slowly added to a solution of 2a or 2b (fourequiv.) in 60 mL of acetonitrile. The reaction mixture was stirred under refluxed for 6h then dried over MgSO4. The solvent was removed under reduced pressure. The solid was dried using a Schlenk line. Transparent oil, yield = 65.69 % .IR ( (cm-1)): 3200 -2858 (CH); 1514 (C=N); 1440 (C=C); 1280 (C-N aromatic);1143 (C-N aliphatic). 1H NMR (300 MHz, CDCl3) (ppm):7.49 – 7 .36 (m, 8H, pz(5) /pz(3)), 6.19 (t, 4H, pz, J = 3 Hz),4.85 (d, 8H, N-CH2-N, J = 3 Hz), 2.50 (t, 4H, N-CH2-CH2 ofamine, J = 3 Hz),1.57 – 1.51 (m, 2H, N-CH2-CH2 of amine).13C NMR (75 MHz, CDCl3, ppm): 139.59 (C(3)pz), 129.57(C(5)pz), 105.91(pz), 67.69(N-CH2-N), 48.85 (N-CH2-CH2 ofamine), 22.96 (N-CH2-CH2 of amine). MS [M+] (m/z): calculated394,48, found 420,12 ([M++ Na+3]).

The synthetic route of 1120-82-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1904-31-0,Some common heterocyclic compound, 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under the protection of nitrogen,The compound 1-methyl-1H-pyrazol-3-amine (200 mg, 2.06 mmol) was suspended in THF (5 mL).Then, CuI (431 mg, 2.27 mmol) and CH2I2 (0.5 mL, 6.18 mmol) were added thereto.Next addNitrosoisoamyl ester(8.30 mL, 61.78 mmol).The mixture was heated to reflux for 5 hours and then cooled to room temperature.Then diluted with EtOAc (15 mL).The resulting mixture was washed with aq. aq.Filtered through a silica gel pad,The filtrate was washed with saturated brine (10 mL).The organic phase was dried over anhydrous sodium sulfate and then evaporated.The residue was chromatographed on silica gel (EtOAc /EtOAcThe title compound was obtained as a yellow liquid (233 mg, 54.4%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazol-3-amine, its application will become more common.

Reference of 31230-17-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixtureof 2, 4,6-trichloropyrimidine (1.00 g, 5. 46 mmol),3-amino-5-methyl-lH- pyrazole (530 mg, 5.46 mmol) and triethylamine (1.1 ml,8. 2 mmol) inEtOH (10 ml) was stirred at room temperature for 1 day. Solvent was removed and the mixture was partitioned between EtOAc and water. The organic layer was concentrated to give the desired product (1.34 g,quantitative). lH NMR (CDC13) :6 2.30(m, 3 H), 5.90 (m, 1 H), 7.85 (m, 1 H), 8.50 (br s,1 H).

The synthetic route of 5-Methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1-Methyl-1H-pyrazol-3-amine

A solution of 1-methyl-1H-pyrazol-3-ylamine (0.92 g, 9.5 mmol) in benzene (4.8 mL) was treated with hexane-2,5-dione (1.34 mL, 11.4 mmol) and para-toluenesulfonic acid (182 mg, 0.95 mmol) and was heated to 115° C. under Dean-Stark conditions for 4 h. After this time, the reaction was cooled to 25° C., concentrated in vacuo and dried under high vacuum overnight. The resulting residue was dissolved in methylene chloride (100 mL) and was washed with water (1.x.150 mL), dried over sodium sulfate, filtered and concentrated in vacuo. Silica gel column chromatography (ISCO, 80 g, 1:4 ethyl acetate/hexanes) afforded 3-(2,5-dimethyl-pyrrol-1-yl)-1-methyl-1H-pyrazole (1.57 g, 94percent) as a green oil; ES+-HRMS m/e calcd for C10H13N3 [M+H+] 176.1182, found 176.1182.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1904-31-0, its application will become more common.