Adding a certain compound to certain chemical reactions, such as: 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67-51-6, Safety of 3,5-Dimethyl-1H-pyrazole
EXAMPLE 5 Synthesis of 1,3,5-Trimethylpyrazole From 3,5-Dimethylpyrazole The apparatus used was the same as that described in Example 1. 24.03 g of 3,5-dimethylpyrazole, i.e. 0.25 mol, and 4.5 g of dimethyl carbonate, i.e. 0.05 mol, were introduced and the reaction medium was heated to 140 C. and this temperature was maintained throughout the reaction.The dimethyl carbonate was then introduced with a flow rate of 50 mmol/h for 8 hours.The methanol produced was distilled off as it was formed and the excess dimethyl carbonate was also distilled off to stabilize the temperature of the reaction medium at 140 C. After having introduced all the dimethyl carbonate, the reaction medium was allowed to cool to ambient temperature to obtain 15.41 g of 1,3,5-trimethylpyrazole, i.e. 0.14 mol, which corresponded to a yield of 57%. The example which follows does not form part of the invention.It was carried out for the purpose of showing that the continuous withdrawal of the methanol produced during the reaction is necessary to be able to generalize this process to several families of nitrogenous heterocycles and particularly, to nitrogenous heterocycles having a boiling point of less than 190 C.
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