Electric Literature of 1904-31-0,Some common heterocyclic compound, 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under the protection of nitrogen,The compound 1-methyl-1H-pyrazol-3-amine (200 mg, 2.06 mmol) was suspended in THF (5 mL).Then, CuI (431 mg, 2.27 mmol) and CH2I2 (0.5 mL, 6.18 mmol) were added thereto.Next addNitrosoisoamyl ester(8.30 mL, 61.78 mmol).The mixture was heated to reflux for 5 hours and then cooled to room temperature.Then diluted with EtOAc (15 mL).The resulting mixture was washed with aq. aq.Filtered through a silica gel pad,The filtrate was washed with saturated brine (10 mL).The organic phase was dried over anhydrous sodium sulfate and then evaporated.The residue was chromatographed on silica gel (EtOAc /EtOAcThe title compound was obtained as a yellow liquid (233 mg, 54.4%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazol-3-amine, its application will become more common.