In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35277-02-2 as follows. Application In Synthesis of 4-Fluoro-1H-pyrazole
In a 100mL single mouth bottle,Add 5-acetyl-2-bromopyridine (1i) (4.00 g, 20 mmol),4-fluoropyrazole (1j) (2.06 g, 24 mmol) and 50 mL of DMF,Reaction at 110 C for 7 hours,The reaction was detected by TLC until the starting point disappeared. After lowering the temperature to room temperature, it was poured into ice water to precipitate a yellow solid, which was washed with a large amount of water, filtered, and dried to obtain 3.31 g of a light yellow solid (1k) with a yield of 81%.
According to the analysis of related databases, 35277-02-2, the application of this compound in the production field has become more and more popular.