Tag: 100-200

In 2012,Kabir, M. Shahjahan; Namjoshi, Ojas A.; Verma, Ranjit; Lorenz, Michael; Phani Babu Tiruveedhula, V. V. N.; Monte, Aaron; Bertz, Steven H.; Schwabacher, Alan W.; Cook, James M. published 《Base-mediated stereospecific synthesis of aryloxy and amino substituted ethyl acrylates》.Journal of Organic Chemistry published the findings.Synthetic Route of C4H3F3N2 The information in the text is summarized as follows:

The stereospecific synthesis of aryloxy and amino substituted E- and Z-ethyl-3-acrylates is of interest because of their potential in the polymer industry and in medicinal chem. During work on a copper-catalyzed cross-coupling reaction of Et (E)- and (Z)-3-iodoacrylates with phenols and N-heterocycles, we discovered a very simple (nonmetallic) method for the stereospecific synthesis of aryloxy and amino substituted acrylates. To study this long-standing problem on the stereoselectivity of aryloxy and amino substituted acrylates, a series of O- and N-substituted nucleophiles was allowed to react with Et (E)- and (Z)-3-iodoacrylates. Screening of different bases indicated that DABCO (1,4-diazabicyclo[2.2.2]octane) afforded successful conversion of Et (E)- and (Z)-3-iodoacrylates into aryloxy and amino substituted Et acrylates in a stereospecific manner. Herein are the details of this DABCO-mediated stereospecific synthesis of aryloxy and amino substituted E- or Z-acrylates. The experimental part of the paper was very detailed, including the reaction process of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Synthetic Route of C4H3F3N2)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Synthetic Route of C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of C6H8N2O2On October 31, 1991 ,《Synthesis of 5-chloropyrazoles by chlorodediazoniation with sulfur dioxide》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Yamamoto, Susumu; Morimoto, Katsushi; Sato, Toshiaki. The article conveys some information:

A facile synthesis of 5-chloropyrazoles I (R = Cl, R1 = Me, R2 = H, R3 = CO2Me, CO2Et, CN; R1 = Ph, R2 = H, R3 = CO2Et; R1 = R2 = Me, R3 = CO2Et) from 5-aminopyrazoles I (R = NH2) via diazotization followed by chlorodediazoniation is described. A new application of sulfur dioxide as a catalyst for the chlorodediazoniation of diazonium chlorides I (R% = N2+Cl-). In the experiment, the researchers used Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2Electric Literature of C6H8N2O2)

Methyl 1-methyl-1H-pyrazole-4-carboxylate(cas: 5952-93-2) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Electric Literature of C6H8N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

SDS of cas: 474432-62-7On October 10, 2002 ,《Interactive SAR Studies: Rational Discovery of Super-Potent and Highly Selective Dopamine D3 Receptor Antagonists and Partial Agonists》 was published in Journal of Medicinal Chemistry. The article was written by Bettinetti, Laura; Schlotter, Karin; Huebner, Harald; Gmeiner, Peter. The article contains the following contents:

Starting from dopamine receptor ligand BP897, an interactive drug discovery process leading to heterocyclic bioisosteres is demonstrated. The four step strategy involved a careful optimization of geometric and electronic properties by systematic modification of the attachment points and heteroatoms, resp. Efficacy tuning by modification of the Ph substituents led to both D3 partial agonists and full antagonists. The benzothiophenes FAUC346 and FAUC365 revealed outstanding D3 affinity and subtype selectivity.Pyrazolo[1,5-a]pyridine-7-carboxylic acid(cas: 474432-62-7SDS of cas: 474432-62-7) was used in this study.

Pyrazolo[1,5-a]pyridine-7-carboxylic acid(cas: 474432-62-7) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. SDS of cas: 474432-62-7

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Formula: C5H6N2O2In 1994 ,《Thermal and photochemical evolution of triazolines obtained by addition of diazo compounds to methyl esters of oximino-malonodinitriles, oximino-cyanoacetates and oximino-malonates》 was published in Canadian Journal of Chemistry. The article was written by Perrocheau, Jacques; Carrie, Robert; Fleury, Jean-Pierre. The article contains the following contents:

Thermolysis of 1,2,3-triazolines I [R = Ts, COC6H4Z-4, Ac; R1 = H, Me, Ph, (MeO)2CH] leads to the corresponding aziridines only when X = Y = CO2Me, and then with a very low yield. However, photolysis or evolution in the presence of trifluoroacetic acid gives good results when carried out at sufficiently low temperature The thermolysis study of I shows a new route to 1,2,3-triazoline decomposition that has not yet been mentioned in the literature. The easy elimination of the p-toluenesulfonate or benzoate group explains this particular behavior. The experimental part of the paper was very detailed, including the reaction process of Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4Formula: C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazoleIn 2019 ,《Chemo- and regioselective reactions of 5-bromo enones/enaminones with pyrazoles》 was published in Organic & Biomolecular Chemistry. The article was written by Moraes, Paulo A.; Lobo, Marcio M.; Marangoni, Mario A.; Meyer, Alexandre R.; Frizzo, Clarissa P.; Bonacorso, Helio G.; Martins, Marcos A. P.; Zanatta, Nilo. The article contains the following contents:

Reaction of 5-bromo enones with pyrazoles provided a series of unexpected N,O-aminal derivatives, I [Y = Me, CF3; R1 = H, Me; R2 = H, Me, n-Pr, etc.; R3 = Me, Et, n-Pr, n-Bu; R1R2 = (CH2)3, (CH2)4] through a 1,4-conjugated addition at the β-carbon of the 5-bromo enones instead of the expected nucleophilic substitution of the bromine. This reaction also furnished the 1,3-regioisomer of the pyrazole. A similar reaction of pyrazoles using 5-bromo enaminones furnished only N-alkylated pyrazoles II [R4 = Me, i-Bu, (CH2)4, etc.] with high regioselectivity and at good yields through nucleophilic substitution of the bromine. In the part of experimental materials, we found many familiar compounds, such as 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Polina, Saibabu; Putta, V. P. Rama Kishore; Gujjarappa, Raghuram; Pujar, Prasad Pralhad; Malakar, Chandi C. published their research in Journal of Heterocyclic Chemistry in 2021. The article was titled 《Aza-Michael addition of 1,2-diazoles to structurally diverse enones: Efficient methods toward β-amino ketones》.COA of Formula: C5H6N2O2 The article contains the following contents:

An efficient and mild protocol was realized using 1,2-diazoles and related heterocycles with cyclic and acyclic enones in presence of T3P (2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide) toward the regioselective formation of N-cycloalkyl heterocycles at room temperature The developed reaction conditions showcased good selectivity over a wide range of 1,2-diazoles and enones by delivering N-cycloalkyl heterocycles in excellent yields. In the experiment, the researchers used many compounds, for example, Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4COA of Formula: C5H6N2O2)

Methyl 1H-pyrazole-3-carboxylate(cas: 15366-34-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.COA of Formula: C5H6N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Nale, Sagar D.; Thombal, Raju S.; Lee, Yong Rok published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Ruthenium(II)-Catalyzed Direct Ortho Functionalization of 1-Arylpyrazoles with Maleimides: A Condition Controlled Installation of Succinimides and Maleimides on Arenes》.Electric Literature of C4H3F3N2 The article contains the following contents:

Ruthenium(II)-catalyzed switchable ortho functionalization of 1-arylpyrazoles I (R1 = 2-Me, 4-OMe, 4-Cl, etc.; R2 = H, Me, CF3) and 1-(1-naphthalenyl)-1H-pyrazole with maleimides II (R3 = C2H5, C6H5, 4-BrC6H4, etc.) is developed in this study. This divergent reaction proceeds via five-membered ruthenacycle formation and selectively installs diverse succinimides III (R4 = 3-Me, 5-OMe, 5-Cl, etc.) and maleimides IV substituents on the aromatic ring of 1-arylpyrazoles I through alkylation and alkenylation under acidic and basic conditions. This methodol. features broad substrate scope, high functional group tolerance, selective functionalization, and superior reactivity. The experimental part of the paper was very detailed, including the reaction process of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Electric Literature of C4H3F3N2)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Electric Literature of C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma》 was written by Chen, Yun; Bai, Gang; Ning, Yi; Cai, Shi; Zhang, Tao; Song, Peiran; Zhou, Jinpei; Duan, Wenhu; Ding, Jian; Xie, Hua; Zhang, Huibin. Quality Control of 3-(Trifluoromethyl)-1H-pyrazole And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

The design, synthesis and structure-activity relationships of imidazo[1,2-b]pyridazines I [R = 2-aminoethyl, 3-amino-piperidin-1-yl, piperazin-1-yl, etc.; R1 = CF2, CF3, CN, etc.; R2 =Me, Et, iPr, etc.; R3 = H, Me] as potent IRAK4 inhibitors was reported. The representative compound I [R = amino-piperidin-3-yl; R1 = CF2; R2 = Me; R3 = H] exhibited excellent IRAK4 potency (IRAK4 IC50 = 1.3 nM) and favorable kinase selectivity profile. It demonstrated cellular selectivity for activated B cell-like (ABC) subtype DLBCL with MYD88 L265P mutation in cytotoxicity assay. The kinase inhibitory efficiency of compound I [R = amino-piperidin-3-yl; R1 = CF2; R2 = Me; R3 = H] was further validated by western blot anal. of phosphorylation of IRAK4 and downstream signaling in OCI-LY10 and TMD8 cells. Besides, combination of compound I [R = amino-piperidin-3-yl; R1 = CF2; R2 = Me; R3 = H] and BTK inhibitor ibrutinib synergistically reduced the viability of TMD8 cells. These results indicated that compound I [R = amino-piperidin-3-yl; R1 = CF2; R2 = Me; R3 = H] could be a promising IRAK4 inhibitor for the treatment of mutant MYD88 DLBCL. After reading the article, we found that the author used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Quality Control of 3-(Trifluoromethyl)-1H-pyrazole)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Quality Control of 3-(Trifluoromethyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2016,Petrella, Stephanie; Aubry, Alexandra; Janvier, Genevieve; Coutant, Eloi P.; Cartier, Alex; Dao, Thuy-Ha; Bonhomme, Frederic J.; Motreff, Laurence; Pissis, Cedric; Bizet, Chantal; Clermont, Dominique; Begaud, Evelyne; Retailleau, Pascal; Munier-Lehmann, Helene; Capton, Estelle; Mayer, Claudine; Janin, Yves L. published 《Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors》.Canadian Journal of Chemistry published the findings.SDS of cas: 20154-03-4 The information in the text is summarized as follows:

A recently discovered series of inhibitors of the ATPase function of bacterial type IIA topoisomerases featuring a carboxypyrrole component led the authors to attempt to replace this group with a potentially bioisosteric carboxypyrazole. Accordingly, synthetic pathways to 2-(4-(1H-pyrazole-5-carboxamido)piperidin-1-yl)thiazole-5-carboxylic acids or 2-(4-(N-methyl-1H-pyrazole-5-carboxamido)piperidin-1-yl)thiazole-5-carboxylic acids featuring an array of substituents on the pyrazole ring were explored. Unfortunately, none of the analogs made were effective on the ATPase function of Mycobacterium tuberculosis gyrase as well on the DNA supercoiling activity of the whole gyrase of M. tuberculosis and Escherichia coli. However, this work is still providing original insights in chem. as well as in the structure-activity relationships of this series of inhibitors. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4SDS of cas: 20154-03-4) was used in this study.

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.SDS of cas: 20154-03-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2012,Bhanuchandra, M.; Kuram, Malleswara Rao; Sahoo, Akhila K. published 《A convenient approach to β-heteroarylated (C-N bond) ketones from Cs2CO3 promoted reaction between propargyl alcohols and nitrogen-heterocycles》.Organic & Biomolecular Chemistry published the findings.Synthetic Route of C4H3F3N2 The information in the text is summarized as follows:

An efficient and direct approach to β-heteroarylated (C-N bond) ketones is demonstrated. Base promoted redox isomerization of propargyl alc. to α,β-unsaturated ketone followed by conjugate addition to NH-heteroarenes affords a wide range of β-heteroarylated ketones in good to excellent yields. Aryl, heteroaryl, alkyl C(sp), and terminal alkynes containing unactivated propargyl alcs. effectively undergo redox-isomerization conjugate addition (RICA) with NH-heteroarenes. Reaction of 3-substituted pyrazoles or indazole with propargyl alcs. enables highly regioselective products. A diverse range of NH-bearing nucleophiles such as: pyrazoles, imidazole, triazoles, pyrrole, indoles, and aniline participate in this reaction and deliver the corresponding β-heteroarylated ketones. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Synthetic Route of C4H3F3N2)

3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Synthetic Route of C4H3F3N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics