SDS of cas: 474432-62-7On October 10, 2002 ,《Interactive SAR Studies: Rational Discovery of Super-Potent and Highly Selective Dopamine D3 Receptor Antagonists and Partial Agonists》 was published in Journal of Medicinal Chemistry. The article was written by Bettinetti, Laura; Schlotter, Karin; Huebner, Harald; Gmeiner, Peter. The article contains the following contents:
Starting from dopamine receptor ligand BP897, an interactive drug discovery process leading to heterocyclic bioisosteres is demonstrated. The four step strategy involved a careful optimization of geometric and electronic properties by systematic modification of the attachment points and heteroatoms, resp. Efficacy tuning by modification of the Ph substituents led to both D3 partial agonists and full antagonists. The benzothiophenes FAUC346 and FAUC365 revealed outstanding D3 affinity and subtype selectivity.Pyrazolo[1,5-a]pyridine-7-carboxylic acid(cas: 474432-62-7SDS of cas: 474432-62-7) was used in this study.
Pyrazolo[1,5-a]pyridine-7-carboxylic acid(cas: 474432-62-7) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. SDS of cas: 474432-62-7
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics