Nale, Sagar D.; Thombal, Raju S.; Lee, Yong Rok published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Ruthenium(II)-Catalyzed Direct Ortho Functionalization of 1-Arylpyrazoles with Maleimides: A Condition Controlled Installation of Succinimides and Maleimides on Arenes》.Electric Literature of C4H3F3N2 The article contains the following contents:
Ruthenium(II)-catalyzed switchable ortho functionalization of 1-arylpyrazoles I (R1 = 2-Me, 4-OMe, 4-Cl, etc.; R2 = H, Me, CF3) and 1-(1-naphthalenyl)-1H-pyrazole with maleimides II (R3 = C2H5, C6H5, 4-BrC6H4, etc.) is developed in this study. This divergent reaction proceeds via five-membered ruthenacycle formation and selectively installs diverse succinimides III (R4 = 3-Me, 5-OMe, 5-Cl, etc.) and maleimides IV substituents on the aromatic ring of 1-arylpyrazoles I through alkylation and alkenylation under acidic and basic conditions. This methodol. features broad substrate scope, high functional group tolerance, selective functionalization, and superior reactivity. The experimental part of the paper was very detailed, including the reaction process of 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Electric Literature of C4H3F3N2)
3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.Electric Literature of C4H3F3N2
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics