In 2016,Petrella, Stephanie; Aubry, Alexandra; Janvier, Genevieve; Coutant, Eloi P.; Cartier, Alex; Dao, Thuy-Ha; Bonhomme, Frederic J.; Motreff, Laurence; Pissis, Cedric; Bizet, Chantal; Clermont, Dominique; Begaud, Evelyne; Retailleau, Pascal; Munier-Lehmann, Helene; Capton, Estelle; Mayer, Claudine; Janin, Yves L. published 《Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors》.Canadian Journal of Chemistry published the findings.SDS of cas: 20154-03-4 The information in the text is summarized as follows:
A recently discovered series of inhibitors of the ATPase function of bacterial type IIA topoisomerases featuring a carboxypyrrole component led the authors to attempt to replace this group with a potentially bioisosteric carboxypyrazole. Accordingly, synthetic pathways to 2-(4-(1H-pyrazole-5-carboxamido)piperidin-1-yl)thiazole-5-carboxylic acids or 2-(4-(N-methyl-1H-pyrazole-5-carboxamido)piperidin-1-yl)thiazole-5-carboxylic acids featuring an array of substituents on the pyrazole ring were explored. Unfortunately, none of the analogs made were effective on the ATPase function of Mycobacterium tuberculosis gyrase as well on the DNA supercoiling activity of the whole gyrase of M. tuberculosis and Escherichia coli. However, this work is still providing original insights in chem. as well as in the structure-activity relationships of this series of inhibitors. In addition to this study using 3-(Trifluoromethyl)-1H-pyrazole, there are many other studies that have used 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4SDS of cas: 20154-03-4) was used in this study.
3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified. Moreover, the medicinal features of a number of natural products incorporating pyrazole moiety such as pyrazofurin, pyrazofurin B, pyrazole-3(5)-carboxylic acid and 4-methylpyrazole-3(5)-carboxylic acid have been reported.SDS of cas: 20154-03-4
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics