Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazoleIn 2019 ,《Chemo- and regioselective reactions of 5-bromo enones/enaminones with pyrazoles》 was published in Organic & Biomolecular Chemistry. The article was written by Moraes, Paulo A.; Lobo, Marcio M.; Marangoni, Mario A.; Meyer, Alexandre R.; Frizzo, Clarissa P.; Bonacorso, Helio G.; Martins, Marcos A. P.; Zanatta, Nilo. The article contains the following contents:
Reaction of 5-bromo enones with pyrazoles provided a series of unexpected N,O-aminal derivatives, I [Y = Me, CF3; R1 = H, Me; R2 = H, Me, n-Pr, etc.; R3 = Me, Et, n-Pr, n-Bu; R1R2 = (CH2)3, (CH2)4] through a 1,4-conjugated addition at the β-carbon of the 5-bromo enones instead of the expected nucleophilic substitution of the bromine. This reaction also furnished the 1,3-regioisomer of the pyrazole. A similar reaction of pyrazoles using 5-bromo enaminones furnished only N-alkylated pyrazoles II [R4 = Me, i-Bu, (CH2)4, etc.] with high regioselectivity and at good yields through nucleophilic substitution of the bromine. In the part of experimental materials, we found many familiar compounds, such as 3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole)
3-(Trifluoromethyl)-1H-pyrazole(cas: 20154-03-4) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazole
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics