Month: May 2021

Application of 2817-71-2, A common heterocyclic compound, 2817-71-2, name is 1-Ethylpyrazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3.102 g (18 mmol) of hydrobromic acid was gradually added dropwise to 1.44 g (15 mmol) of 1-ethylpyrazole,The reaction was stirred at 40 ~ 50 for 15 ~ 25h to ensure that all the substrates reacted completely, then cyclohexane was used as a water-carrying agent to remove the moisture therein,Further washing with ethyl acetate gave 1-ethylpyrazole hydrobromide as a pale yellow liquid (yield> 90%).

The synthetic route of 2817-71-2 has been constantly updated, and we look forward to future research findings.

Related Products of 60061-68-9, A common heterocyclic compound, 60061-68-9, name is 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole, molecular formula is C5H4BrF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 37; [4-(5-Methyl-3-trifluoromethyl-1H-pyrazol-4-vfl-phenviyacetonitrile; 37A. 4-Bromo-5-methyl-1 -(tetrahvdro-pyran-2-yl)-3-trifluoromethyl-1 H-pyrazole; To a solution of 4-bromo-5-methyl-3-trif.uorornethy.-1 H-pyrazole (1.4g, 6.2mmol, LOequiv) in chloroform (31ml) was added p-toluene sulphonic acid monohydrate (118mg, 0.62mmol, O.iequiv). The solution was cooled to EPO O0C and 3,4-dihydro-2H-pyran (0.85ml, 9.3mmol, 1.5equiv) was added drop-wise over 5 minutes. The mixture was allowed to warm to room temperature for 1 hour and the solvents were removed under reduced pressure. The crude mixture was purified by column chromatography (Sitheta2), eluting with 0->25% EtOAc-petrol over a linear gradient to afford the title compound 1.4 g (59%), LCMS (PS-A) R1 3.72 min [M+H]+ 314.

The synthetic route of 60061-68-9 has been constantly updated, and we look forward to future research findings.

Reference of 20154-03-4,Some common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, molecular formula is C4H3F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 2, 3-dichloropyridine (99.0 g, 0.67 mol) and 3-(trifluoromethyl)pyrazole (83 g, 0.61 mol) in N,N-dimethylformamide (300 ml) was added potassium carbonate (166.0 g, 1.2 mol) and the reaction was then heated to 110-125 °C over 48 hours. The reaction was cooled to 100 °C and filtered through Celite.(R).) diatomaceous filter aid to remove solids. N,N-dimethylformamide and excess dichloropyridine were removed by distillation at atmospheric pressure. Distillation of the product at reduced pressure (b. p. 139-141 °C, 7 mm) afforded 113.4 g of the desired intermediate as a clear yellow oil. 1H NMR (CDCl3): delta 8.45 (d,1H), 8.15 (s,1H), 7.93 (d,1H), 7.36 (t,1H), 6.78 (s,1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(Trifluoromethyl)-1H-pyrazole, its application will become more common.

Related Products of 35344-95-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Preparation 52: l-(2-Hydroxy-ethyl)-lH-pyrazole-4-carbaldehyde Combine lH-pyrazole-4-carbaldehyde (0.110 g, 1.14 mmol), 2-bromoethanol(0.172 g, 1.37 mmol), and potassium carbonate (0.236 g, 1.71 mmol) in acetonitrile (2 mL). Heat in microwave at 150 0C for 20 min.. Cool to room temperature and filter, washing with acetonitrile. Concentrate filtrate to give the title preparation (0.155 g, 97percent). GC-MS: m/z = 140 [M+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1280210-79-8 as follows. name: tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate

A mixture of (1R,2R)-N1,N2-dimethylcyclohexane-1,2-diamine (25 uL, 0.158 mmol), copper (I) iodide (4.0 mg, 0.021 mmol), potassium phosphate tribasic (69.7 mg, 0.328 mmol), tert-butyl 4,6-dihydro-2H-pyrrolo[3,4-c]pyrazole-5-carboxylate (42.7 mg, 0.204 mmol) and [(3R,3aR,6R,6aS)-3-(1-allyl-6-chloro-5-iodo-imidazo[4,5-b]pyridin-2-yl)oxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl]oxy-tert-butyl-dimethyl-silane (84 mg, 0.145 mmol) in dioxane (1.0 ml) was degassed (3×) and placed under nitrogen before being heated to 100 C. After 6 hours, the reaction mixture was diluted with EtOAc (30 ml), washed with water (20 ml), brine (10 mL), dried over MgSO4, filtered, and evaporated under reduced pressure to give an oil. The oil was purified on preparative silica plates (1×1000 u developed with 1:1 EtOAc/hexanes). The resulting solid (86.4 mg, 0.131 mmol) was dissolved in TFA (1.0 mL) and DCM (1.0 mL) and was stirred at room temperature. After 1 hour, the reaction mixture was evaporated to give an oil, and which was lyophilized from ethanol and benzene to give the title compound as a solid. LC-MS: calculated for C26H35ClN6O4Si 558.22 observed m/e: 559.27 (M+H)+ (Rt 1.15/2 min).

According to the analysis of related databases, 1280210-79-8, the application of this compound in the production field has become more and more popular.

Related Products of 52222-73-8,Some common heterocyclic compound, 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, molecular formula is C4H3F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Production Example 63A mixture of 0.28 g of 2-(3-fluoropyridin-4-yl)-5-(trifluoromethyl)benzoxazole, 0.18 g of 4-(trifluoromethyl)pyrazole, 0.55 g of potassium carbonate and 2 ml of DMF was stirred while heating at 50C for 1.5 hours. The reaction mixture was cooled to room temperature. Water was added to the reaction mixture, followed by extraction with ethyl acetate twice. The combined organic layers were washed with a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 0.36 g of 2- { 3 – [4-(trifluoromethyl)pyrazole- 1 -yl]pyridin-4-yl } -5 -(trifluoromethyl)benzoxazole (hereinafter, referred to as “active compound 62”).Active compound 621 H-NMR (CDC13) delta: 8.96 (d, J=5.1 Hz, IH), 8.93 (d, J=0.5 Hz, IH), 8.21 (dd, J=5.1, 0.5 Hz, IH), 8.13-8.11 (m, IH), 8.05-8.04 (m, IH), 7.95 (s, IH), 7.71-7.68 (m, IH), 7.56 (d, J=8.8 Hz, IH)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Trifluoromethyl)-1H-pyrazole, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 934758-92-6, name is 5-Chloro-1H-pyrazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H3ClN2

To a soution of 5-choro-1H-pyrazoe (3.88 g, 35.2 mmoD in AcOH (5.10 m, 89 mmoD was added at 0C dropwise 90% aqueous HNO3 (5.10 m, 35.2 mmo) and the reaction mixture was stirred at 0C for 2h. Ac20 (12.92 mL 137 mmo) was then added dropwise. The mixture was stirred at RT for 4h, The mixture was poured nto ce-water and AcOEt and Na2003 (33.6 g, 317 mmo) were added. The organic phase was separated and the aqueous phase was extracted with AcOEt, The combined organic ayers were washed with aqueous saturated NaHCO3 and brine, dried over Na2SO4 and concentrated to afford 5-choro-1-nitro-1H-pyrazoe. M/z = 146/148 [M-Hj-. Rt = 0.71 mm (UPLC Method E32), 1H NMR (400 MHz, DMSO-d6): 6 ppm: 8.91 (d, IH), 6.90 (d, IH).

The synthetic route of 934758-92-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1260243-04-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 53 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid, ethyl ester A stirred mixture of 10.88 g of 5-amino-4-pyrazolecarboxylic acid, ethyl ester, 11.51 g of malonaldehyde bis(dimethyl acetal) and 100 ml of glacial acetic acid was heated at reflux for 16 hours, then worked up as described in Example 50 to give 7.8 g of pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, ethyl ester.

The synthetic route of Ethyl 5-amino-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

Electric Literature of 84547-86-4, A common heterocyclic compound, 84547-86-4, name is 4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H5BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[00474] EXAMPLE 42A. Synthesis of Compound 265.[00 4-bromo-N-methoxy-N,l-dimethyl-lH-pyrazole-3-carboxamide. A mixture of 4-bromo-l -methyl- lH-pyrazole-3-carboxylic acid (2.04 g, 10 mmol), 2-(lH-benzotriazole-l-yl)-l,l,3,3-tetramethyluronium tetrafluoroborate (3.21 g, 10 mmol), Nu,Omicron-dimethylhydroxylamine (1.22 g, 20 mmol) in N,N-Diisopropylethylamine (5 mL) and N,N-Dimethylformamide (20 mL) was stirred for 12 h at room temperature. The mixture was concentrated in vacuum, and the residue was purified by flash chromatography eluting with petroleum ether/ethyl acetate = 5: 1 to give the titled product as a colorless oil (2.4 g, 97%). LC/MS m/z 247 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17827-61-1, name is Methyl 1-Methylpyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 17827-61-1

Step 2: To a solution of step 1 intermediate (7.0 g, 50 mmol) in a mixture of THF (20 mL) and MeOH (20 mL) was added a solution of LiOH H20 (4.2 g, 100 mmol) in water (20 mL) at 0C. The RM was stirred at rt for 3 h. The RM was concentrated and subsequently diluted with water. The aqueous layer was acidified with sat. NaHS04 solution up to pH~4-5 and extracted with EtOAc. The combined organic layers were dried and concentrated under reduced pressure to yield the desired product (6.2 g, 98%). LC-MS (Method 3): m/z [M+H]+ = 127.2 (MW calc. 126.11); R, = 0.44 min.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.