Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 934758-92-6, name is 5-Chloro-1H-pyrazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H3ClN2
To a soution of 5-choro-1H-pyrazoe (3.88 g, 35.2 mmoD in AcOH (5.10 m, 89 mmoD was added at 0C dropwise 90% aqueous HNO3 (5.10 m, 35.2 mmo) and the reaction mixture was stirred at 0C for 2h. Ac20 (12.92 mL 137 mmo) was then added dropwise. The mixture was stirred at RT for 4h, The mixture was poured nto ce-water and AcOEt and Na2003 (33.6 g, 317 mmo) were added. The organic phase was separated and the aqueous phase was extracted with AcOEt, The combined organic ayers were washed with aqueous saturated NaHCO3 and brine, dried over Na2SO4 and concentrated to afford 5-choro-1-nitro-1H-pyrazoe. M/z = 146/148 [M-Hj-. Rt = 0.71 mm (UPLC Method E32), 1H NMR (400 MHz, DMSO-d6): 6 ppm: 8.91 (d, IH), 6.90 (d, IH).
The synthetic route of 934758-92-6 has been constantly updated, and we look forward to future research findings.