Category: 2817-71-2

Some common heterocyclic compound, 2817-71-2, name is 1-Ethylpyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Ethylpyrazole

General procedure: In athree-necked bottle, 0.82 g (10 mmol)1-methylpyrazole and 1.25 g(10mmol) bromoethanolwere added into 10mL CH3CN. Then, themixtureswere stirred at reflux temperature for 48 h in a nitrogen atmosphere.After the reaction, the volatiles were removed under reducedpressure. The residual was washed several times by ethyl acetate togive a white solid. After filtration and drying in vacuum, the pureHEMPzBr was obtained: 1.532 g, yield 74%, white solid. 1H NMR(400 MHz, DMSO-d6) delta 8.58 (dd, J = 21.9, 2.8 Hz, 2H, Pz-H), 6.86 (t, J = 3.1 Hz, 1H, Pz-H), 5.26 (s, 1H, -OH), 4.61 (t, J = 5.0 Hz, 2H, -CH2-),4.20 (s, 3H, -CH3), 3.76 (t, J = 5.2 Hz, 2H, -CH2-).13C NMR (101 MHz,D2O) delta 138.38, 137.98, 107.43, 59.34, 52.34, 37.61. HR-MS (QTOF)calcd. for [C6H11N2O+] (m/z): 127.0866, found: 127.0868.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2817-71-2, its application will become more common.

Reference:
Article; Wang, Tengfei; Ma, Yuan; Jiang, Jiamin; Zhu, Xinrui; Fan, Baowan; Yu, Guanyao; Li, Ningning; Wang, Shasha; Ren, Tiegang; Wang, Li; Zhang, Jinglai; Journal of Molecular Liquids; vol. 293; (2019);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 2817-71-2, A common heterocyclic compound, 2817-71-2, name is 1-Ethylpyrazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3.102 g (18 mmol) of hydrobromic acid was gradually added dropwise to 1.44 g (15 mmol) of 1-ethylpyrazole,The reaction was stirred at 40 ~ 50 for 15 ~ 25h to ensure that all the substrates reacted completely, then cyclohexane was used as a water-carrying agent to remove the moisture therein,Further washing with ethyl acetate gave 1-ethylpyrazole hydrobromide as a pale yellow liquid (yield> 90%).

The synthetic route of 2817-71-2 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2817-71-2 as follows. Application In Synthesis of 1-Ethylpyrazole

Weigh 0.05 mol of 1-ethyl-1-H-pyrazole (4.8 g) and 0.05 mol of 3-bromopropylamine hydrobromide (10.946 g)Add to a three-necked flask, add 20 mL of absolute ethanol as a solvent, and stir at 80 C for 72 h.After cooling to room temperature, a white solid was separated from anhydrous ethanol, filtered, washed three times with 10 mL of anhydrous ethanol, and dried in a vacuum oven overnight to give a white powder solid.3.15 g of a white powder solid was dissolved in 10 mL of distilled water, the pH was adjusted to about 9 with KOH, and stirred at room temperature for 30 minutes, and then the water in the system was removed with cyclohexane.Pour out cyclohexane.The mixture was extracted with a mixed solution of tetrahydrofuran and methanol, and the inorganic salt solid was removed by filtration, and the obtained liquid was concentrated to give a yellow viscous liquid, yield: 85.16%.

According to the analysis of related databases, 2817-71-2, the application of this compound in the production field has become more and more popular.