Electric Literature of 84547-86-4, A common heterocyclic compound, 84547-86-4, name is 4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H5BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[00474] EXAMPLE 42A. Synthesis of Compound 265.[00 4-bromo-N-methoxy-N,l-dimethyl-lH-pyrazole-3-carboxamide. A mixture of 4-bromo-l -methyl- lH-pyrazole-3-carboxylic acid (2.04 g, 10 mmol), 2-(lH-benzotriazole-l-yl)-l,l,3,3-tetramethyluronium tetrafluoroborate (3.21 g, 10 mmol), Nu,Omicron-dimethylhydroxylamine (1.22 g, 20 mmol) in N,N-Diisopropylethylamine (5 mL) and N,N-Dimethylformamide (20 mL) was stirred for 12 h at room temperature. The mixture was concentrated in vacuum, and the residue was purified by flash chromatography eluting with petroleum ether/ethyl acetate = 5: 1 to give the titled product as a colorless oil (2.4 g, 97%). LC/MS m/z 247 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.