The important role of 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole

The synthetic route of 60061-68-9 has been constantly updated, and we look forward to future research findings.

Related Products of 60061-68-9, A common heterocyclic compound, 60061-68-9, name is 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole, molecular formula is C5H4BrF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 37; [4-(5-Methyl-3-trifluoromethyl-1H-pyrazol-4-vfl-phenviyacetonitrile; 37A. 4-Bromo-5-methyl-1 -(tetrahvdro-pyran-2-yl)-3-trifluoromethyl-1 H-pyrazole; To a solution of 4-bromo-5-methyl-3-trif.uorornethy.-1 H-pyrazole (1.4g, 6.2mmol, LOequiv) in chloroform (31ml) was added p-toluene sulphonic acid monohydrate (118mg, 0.62mmol, O.iequiv). The solution was cooled to EPO O0C and 3,4-dihydro-2H-pyran (0.85ml, 9.3mmol, 1.5equiv) was added drop-wise over 5 minutes. The mixture was allowed to warm to room temperature for 1 hour and the solvents were removed under reduced pressure. The crude mixture was purified by column chromatography (Sitheta2), eluting with 0->25% EtOAc-petrol over a linear gradient to afford the title compound 1.4 g (59%), LCMS (PS-A) R1 3.72 min [M+H]+ 314.

The synthetic route of 60061-68-9 has been constantly updated, and we look forward to future research findings.