Day: March 17, 2021

Adding a certain compound to certain chemical reactions, such as: 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25016-20-0, Computed Properties of C5H6N2O2

Acid R2a (13.9 mg; 0.1 10mmol) is dissolved in DMF (2 mL) and TEA (51.2 muIota 0.367 mmol) and TBTU (34.0 mg; 0.1 10 mmol) are added and the mixture is stirred for 15 mins. The Boc de-protected macrocyclic amine hydrochloride Cf is dissolved in DMF (1.0 mL) and added to the acid solution and stirred at RT overnight. The resulting solution is filtered through a Millex filter and purified by prep HPLC (ammonium bicarbonate/MeOH). The pure fractions are combined, concentrated, frozen and lyophilized to provide compound 1003.FIA M.S.(electrospray) : 822.5/ 824.5 (M-H)- , 824.4/ 826.3 (M+H)+Retention time (min): 7.0 min1H NMR (400 MHz,DMSO-d6): delta 10.83 (s, 1 H) , 8.92 (s, 1 H), 7.86 (d, 1 H, J = 8.6 Hz), 7.79 (d, 1 H, J = 5.1 Hz), 7.75 (d, 1 H, J = 2 Hz), 7.29 (d, 1 H, J = 8.6 Hz), 6.57 (s, 1 H), 6.53 (d, 1 H, J = 2 Hz), 5.67- 5.55 (m, 1 H), 5.55- 5.44 (m, 2H), 5.12- 5.00(m, 1 H), 4.62- 4.50 (m, 2H), 4.45- 4.37 (m, 1 H), 4.05- 3.95 (m, 1 H), 3.88 (s, 3H), 2.66 (s, 3H), 2.40- 2.25 (m, 2H), 2.03- 1.87 (m, 1 H), 1.87-1.72 (m, 1 H), 1.60- 1.47(m, 3H), 1.47-1.15 (m, 19H), 0.95- 0.78 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 1904-31-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

Accordingly, as shown in step 3-i of Scheme 3, 1-methyl-1H-pyrazol-3-amine (compound 1007, 2.8 g, 28.8 mmol) and 2,5-hexanedione (3.38 mL, 28.8 mmol) were dissolved into 50 mL of toluene. p-Toluenesulfonic acid (1.4 mmol) was added, the reaction mixture refluxed, and water generated from the reaction collected in a Dean-Stark trap.When no more water was generated (about 4 hours), the reaction mixture was cooled and the volatiles removed under reduced pressure.The residue was passed through a plug of silica gel using dichloromethane as eluent to yield an oil, which solidified upon standing.The solid was broken up, suspended in hexane, vigorously stirred for one hour, and collected by filtration to provide 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole (compound 1008, 5.0 g, 98percent yield) as a white powder: ESMS (M+1)=175; 1H-NMR (CDCl3) delta 7.38 (d, J=4 Hz, 1H), 6.14 (d, J=4 Hz, 1H), 5.84 (s, 2H), 3.95 (s, 3H), 2.09 (s, 6H).

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 143426-52-2, name is 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 143426-52-2

Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine-8-carboxylate (250 mg, 0.83 mmol, 1.0 eq.), 4-(1-pyrazolyl)benzyl chloride (319 mg, 1.7 mmol, 2.0 eq.), cesium carbonate (542 mg, 1.6 mmol, 2.0 eq.), Pd(dppf)Cl2.DCM (101 mg, 0.12 mmol, 0.15 eq.), THF (5.5 mL) and H2O (1 mL) were added into a microwave vial. The vial was evacuated and purged with N2 (3*). The mixture was stirred at 90 C. After 1 h, the mixture was cooled to r.t., filtered through a pad of Celite which was rinsed thoroughly with EtOAc/DCM/MeOH. The filtrate was concentrated and purified using column chromatography on silica gel (0-50% DCM/EtOAc for 15 min then 50-100% of 10% MeOH/DCM solution) to provide the title compound with some impurities. Further purification was conducted using RP-HPLC (25-60% MeCN in 0.05% NH4OH aqueous solution over 20 min). The desired fractions were concentrated to provide the title compound as a tan solid (170 mg, 62%). 1H-NMR (400 MHz, DMSO) delta 8.73 (s, 1H), 8.46 (d, J=2.4 Hz, 1H), 8.04 (d, J=1.2 Hz, 1H), 7.81-7.78 (m, 2H), 7.72 (d, J=1.7 Hz, 2H), 7.63 (d, J=1.2 Hz, 1H), 7.44-7.42 (m, 2H), 6.53 (t, J=2.1 Hz, 1H), 4.06 (s, 2H), 3.87 (s, 3H); ES-MS [M+H]+=333.2.

According to the analysis of related databases, 143426-52-2, the application of this compound in the production field has become more and more popular.

Electric Literature of 138786-86-4, The chemical industry reduces the impact on the environment during synthesis 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.

Methyl 4-nitro-lH-pyrazole-3-carboxylate (5 g, 29.2 mmol),Toluenesulfonic acid (0.5 g, 2.9 mmol) was dissolved in dichloromethane (40 mL)3,4-Dihydro-2H-pyran (3.7 g, 44.0 mmol) was added dropwise at 0 C. The addition was completed, 20 C for 4 hours,Add 100mL dichloromethane and 100mL water, liquid separation, the organic phase spin dry,The residue was subjected to silica gel column chromatography (PE: EA = 10: 1) to give 5.3 g of the title product in a yield of 71.1%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-nitro-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4058-91-7, name is 5-Amino-1-methyl-1H-pyrazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Quality Control of 5-Amino-1-methyl-1H-pyrazole-4-carboxylic acid

56 To a solution of 5-AMINO-L-METHYL-LH-PYRAZOLE-4- carboxylic acid (7.1 g), N- (2-AMINOETHYL) tritylamine (15.1 g) and triethylamine (10.1 g) in chloroform (200 ml) was added N- (3-DIMETHYLAMINOPROPYL)-N – ethylcarbodiimide hydrochloride (9.6 g), and the mixture was stirred at room temperature for 16 hours. The reaction mixture was washed successively with 10% aqueous citric acid solution, brine and saturated aqueous sodium hydrogencarbonate solution. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was triturated with ethyl acetate and dried in vacuo to give 5-AMINO-1- METHYL-N- [2- (TRITYLAMINO) ETHYL]-LH-PYRAZOLE-4- carboxamide (11.4 g) as a solid. 1H-NMR (CDCl3) 8 2.35-2. 38 (2H, m), 3.45-3. 49 (2H, M), 3.63 (3H, s), 5.15 (1H, br), 5.91 (1H, br), 7.17-7. 49 (16H, m)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 14531-55-6,Some common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, molecular formula is C5H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3,5-dimethyl-4-nitro-1 H-pyrazole (0.5 g, 3.54 mmol) in acetonitrile (10 mL), K2C03 (1.4 g, 10.62 mmol) was added and the mixture was stirred at room temperature for 30 minutes. Then tert-butyl-(2-chloroethoxy)dimethylsilane (1.2 g, 5.31 mmol) was added dropwise. The mixture was heated at reflux overnight. To the cooled reaction mixture H20 (20 ml) was added and the product was extracted with ethyl acetate (3 x 50 ml), the organic layers were combined, dried over Na2S04 and evaporated under reduced pressure. The residue was purified on HP-Sil SNAP cartridges using a Biotage Isolera One purification system employing an EtOAc/n-heptane gradient (5/95 -> 40/60) to afford the title compound which was used in the next step without further purification (0.72 g, 68 %). 1H-NMR (400 MHz, DMSO-d6) delta = 4.20 (t, 2H), 3.90 (t, 2H), 2.60 (s, 3H), 2.41 (s, 3H), 0.78 (s, 9H), -0.09 (s, 6H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dimethyl-4-nitro-1H-pyrazole, its application will become more common.

31108-57-3, name is 1H-Pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C4H3N3

Prepared according General Procedure E, Step 2 from compound Cll (60 mg, 0.14 mmol) and lH-pyrazole-4-carbonitrile (63 mg, 0.67 mmol), with purification by column chromatography on silica gel to provide compound 27 as an off-white solid (27.3 mg, 44%): mp 176-178 C; 1HNMR (300 MHz, CDCI3) delta 7.83 (d, J = 12.3 Hz, 2H), 4.95 (q, J = 18.3 Hz, 2H), 3.53 (d, J = 9.0 Hz, IH), 3.33 (s, 3H), 3.22 (d, J = 9.0 Hz, IH), 2.59 (t, J = 9.3 Hz, IH), 2.26-1.35 (m, 17H), 1.31-1.08 (m, 9H), 0.66 (s, 3H) ppm; ESI MS m/z 437 [M+H-H2Of .

The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.

Application of 25016-17-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-17-5, name is Methyl 5-methyl-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

b) Method for svnthesising the pyrazolecarboxylic acid ED-2b (synthesis method B)ED-5a (2.00 g, 14.3 mmol) in DMF (7 mL) is added dropwise to a suspension of NaH (694 mg, 60 %, 17.4 mmol) in anhydrous DMF (8 mL) while cooling with ice and the mixture is slowly thawed to RT over 1 h. Then isopropyl bromide (2.7 mL, 28.8 mmol) is added and the mixture is stirred for 20 h at RT. The reaction mixture is mixed with a little water, then for saponification aqueous LiOH solution (414 mg in 3 mL H20) is added and the mixture is stirred for 2 h at 40C. The reaction mixture is neutralised with hydrochloric acid, evaporated down to some extent using the rotary evaporator and the residue is purified by preparative RP-MPLC. The product-containing fractions of ED-2b (HPLC-MS: tRet. = 0.00 min; MS (M-H)” = 167) are combined and freeze-dried.

The chemical industry reduces the impact on the environment during synthesis Methyl 5-methyl-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.

Synthetic Route of 5203-77-0,Some common heterocyclic compound, 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Weigh 1.7g (0.015mol) 1,3- dimethyl-5-pyrazolone-ol in 250mLthree-necked flask was added 50mL1,2-Dichloroethane was dissolved and weighed 4.0g (0.040mol) oftriethylamine in the system. Under ice cooling, Intermediate (a-2) of1,2-dichloroethane solution (0.010mol (a-2)) was addeddropwise to the system, during the addition using argon. After the reaction 1hThe reaction was followed by HPLC, the reaction was completefeed reaction solution containing intermediate (a-3) a. Counter-containingintermediate (a-3) ofLiquid should be supplemented with 1.0g (0.010mol) oftriethylamine and several drops of acetone cyanohydrin, temperature controlledat 50 ~ 60 and argon gas protectionProtection, response 2h, HPLC trace reaction. Aftercompletion of the reaction was added 100mL of water was slowly added dropwiseHCl, stirring at room temperature, until pH = 3about. 200mL extract was washed with water to remove theaqueous layer, the organic layer was washed twice, dried over anhydrous sodiumsulfate, the organic solvent was removed by rotary evaporation,To give 3.6g a tan solid, a powdered compound a.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3-Dimethyl-1H-pyrazol-5-ol, its application will become more common.

Application of 473528-88-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 473528-88-0, name is 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Preparation 142: 1 -Methyl-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 H-pyrazole- e A mixture of 4-bromo-1 -methyl-1 H-pyrazole-5-carbaldehyde (150 mg, 0.794 mmol), KOAc (234 mg, 2.38 mmol), Pd(dppf)CI2 FontWeight=”Bold” FontSize=”10″ DCM (33.6 mg, 0.040 mmol) and bis(pinacolato)diboron (222 mg, 0.873 mmol) in dioxane (4 mL) was stirred at ^ 00 oC under microwave irradiation for 1 hour. The reaction mixture was diluted with EtOAc. The mixture was filtered and purified using Biotage silica gel column chromatography eluting with 20% EtOAc/ cyclohexanes to give the title compound (96 mg, 51 %). 1 H NMR (500 MHz, CDCI3): 0 10.28 (s, 1 H), 7.79 (s, 1 H), 4.20 (s, 3H), 1 .34 (s, 12H). LCMS (ESI) Rt = 2.55 minutes MS m/z 237 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.