Application of 14531-55-6,Some common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, molecular formula is C5H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 3,5-dimethyl-4-nitro-1 H-pyrazole (0.5 g, 3.54 mmol) in acetonitrile (10 mL), K2C03 (1.4 g, 10.62 mmol) was added and the mixture was stirred at room temperature for 30 minutes. Then tert-butyl-(2-chloroethoxy)dimethylsilane (1.2 g, 5.31 mmol) was added dropwise. The mixture was heated at reflux overnight. To the cooled reaction mixture H20 (20 ml) was added and the product was extracted with ethyl acetate (3 x 50 ml), the organic layers were combined, dried over Na2S04 and evaporated under reduced pressure. The residue was purified on HP-Sil SNAP cartridges using a Biotage Isolera One purification system employing an EtOAc/n-heptane gradient (5/95 -> 40/60) to afford the title compound which was used in the next step without further purification (0.72 g, 68 %). 1H-NMR (400 MHz, DMSO-d6) delta = 4.20 (t, 2H), 3.90 (t, 2H), 2.60 (s, 3H), 2.41 (s, 3H), 0.78 (s, 9H), -0.09 (s, 6H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dimethyl-4-nitro-1H-pyrazole, its application will become more common.