Electric Literature of 138786-86-4, The chemical industry reduces the impact on the environment during synthesis 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.
Methyl 4-nitro-lH-pyrazole-3-carboxylate (5 g, 29.2 mmol),Toluenesulfonic acid (0.5 g, 2.9 mmol) was dissolved in dichloromethane (40 mL)3,4-Dihydro-2H-pyran (3.7 g, 44.0 mmol) was added dropwise at 0 C. The addition was completed, 20 C for 4 hours,Add 100mL dichloromethane and 100mL water, liquid separation, the organic phase spin dry,The residue was subjected to silica gel column chromatography (PE: EA = 10: 1) to give 5.3 g of the title product in a yield of 71.1%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-nitro-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.