Day: March 15, 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, A new synthetic method of this compound is introduced below., Formula: C10H15N3O2

3 -(Bromomethyl)- 1,1 -difluoro-cyclobutane (505 mg, 2.73 mmol) was added dropwisc over 15 mm, to a mixture of tert-butyl 4,6-dihydro-2H-pyrrolo[3,4- c]pyrazole-5-carboxylate (560 mg, 2.67 mmol), cesium carbonate (1.39 g, 4.28 mmol) and DMF (5 mL) at 0 C. The reaction mixture was allowed to warm to ambient temperature and stirred for 18 h. The solvent was concentrated and the material was partitioned betweenwater (50 mL) and EtOAc. The aqueous layer was washed with EtOAc (2 x 30 mL). The combined organic layers were washed with brine, dried (MgSO4), and the solvent was concentrated. Purification (FCC, Si02 using ether) provided the title compound (344 mg, 41%). ?H NMR (300 MHz, CDC13) 3 = 7.10 (d, J = 10.0 Hz, 1H), 4.50 -4.37 (m, 4H), 4.18 (d, J = 5.5 Hz, 2H), 2.78-2.56 (m, 3H), 2.47-2.25 (m, 2H), 1.50 (s, 9H); [M+H] = 314.26.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 75415-03-1,Some common heterocyclic compound, 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, molecular formula is C8H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of CuCl2¡¤4H2O (20.84 mg, 0.1 mmol), Hpzpy(28.84 mg, 0.2 mmol), DMF (3 mL) and H2O(1 mL) wassealed in a 25-ml Teflon-lined stainless container and heatedat 130 C for 72 h. After cooling to room temperature at arate of 5 C/h, colorless block crystals were obtained in ca.62% yield based on Cu. Anal. Calcd. for C18H18Cu2N6O6:C 39.93%, H 3.35%, N 15.52%; found C 39.84%, H 3.24%,N 15.48%. IR (KBr, cm-1): 3138 w, 2040 s, 1584 s, 1512 w,1438 m, 1372 w, 1245 w, 1089 s, 1028 w, 777 m, 723 m,705 w, 692 w, 623 m.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1H-Pyrazol-3-yl)pyridine, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19968-17-3, name is 4-Bromo-3-(trifluoromethyl)-1H-pyrazole, A new synthetic method of this compound is introduced below., COA of Formula: C4H2BrF3N2

To a solution of 4-bromo-3- (trifluoromethyl) -1H-pyrazole (1.01 g, 4.7 mmol) in DMF (40 mL)2- (bromineMethyl) pyridine hydrobromide (1.76 g, 6.96 mmol), Cs2CO3 (5.3 g, 16 mmol) and KI (0.4 g, 2 mmol)100 for 10h. The reaction mixture was concentrated under reduced pressure to remove DMF, extracted with water (40 mL) and extracted with methylene chloride (50 mL ¡Á 3), and then the organicThe phases were dried over anhydrous Na2SO4. The concentrated crude product was isolated by silica gel column chromatography (eluent: PE / EtOAc (v / v) = 1 /1) to give 1.2 g of a yellow oil, yield: 83%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 105434-90-0, The chemical industry reduces the impact on the environment during synthesis 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.

LAH (20 mg, 0.51 mmol) was added to an ice cooled solution of ethyl 5-amino-l-((2-(5-phenylisoxazole-3-carboxamido)ethyl)sulfonyl)-lH- pyrazole-3-carboxylate (100 mg, 0.2537 mmol) in THF (10 mL) and the reaction mixture was stirred for 1 h at the same temperature. Then the reaction mixture was quenched with saturated NH4C1 solution and filtered through celite pad. The filtrate was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford crude compound which was further purified by preparative HPLC to obtain N-(2-((5-amino-3-(hydroxymethyl)-lH-pyrazol-l- yl)sulfonyl)ethyl)-5-phenylisoxazole-3-carboxamide (23 mg, 7% over two steps). (0261) [00169] Appearance: white solid (0262) [00170] Analytical data: XH NMR (400 MHz, DMSO-d6): delta 8.89-8.87 (m, IH), 7.94-7.92 (m, 2H), 7.58-7.54 (m, 3H), 7.36 (s, IH), 6.07 (s, D20 exchangeable, 2H), 5.34 (s, IH), 5.16 (t, J=6.0 Hz, IH), 4.25 (d, J=6.0 Hz, 2H), 3.76 (t, J=6.6 Hz, 2H), 3.61-3.56 (m, 2H). (0263) [00171] LC-MS: [M+H]+=391.9 (0264) [00172] HPLC Purity: 98.50% at 254 nm and 98.37% at 220 nm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Related Products of 5334-39-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of 3-methyl-4-nitro-lH-pyrazole (5 g, 39.34 mmol) and (R)-2- methyloxirane (3.43 g, 59.01 mmol, 4.13 mL) in DMF (50 mL) was added Cs2C03 (19.23 g, 59.01 mmol) at 20 C. The mixture was heated to 80 C and stirred for 15 h then cooled to 20 C and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc = 10: 1 to 0: 1) to give the mixture of (R)-l-(5-methyl-4-nitro-lH-pyrazol-l -yl)propan-2-ol and (R)-l-(3-methyl-4-nitro-lH-pyrazol-l-yr)propan-2-ol as a yellow liquid. LCMS: RT 0.133 min, m/z = 186.1 [M+H]+ To a solution of the mixture (R)-l-(5- methyl-4-nitro-lH-pyrazol-l -yl)propan-2-ol and (R)-l -(3-methyl-4-nitro-lH-pyrazol-l-yl)propan-2-ol (3 g, 16.2 mmol) in CH3CN (150 mL) was added Cul (617 mg, 3.24 rnmol), then a solution of 2,2-difluoro- 2-fluorosulfonyl-acetic acid (4.33 g, 24.30 mmol, 2.5 mL) in CH3CN (150 mL) dropwise at 20 C over a period of 30 min under N2. The reaction mixture was wanned to 55 C and stirred for 2 h then cooled to 20 C and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc :=: 10: 1 to 0: 1) to give the mixture of (R)-l-(2-(difluoromethoxy)propyl)-5- methyl -4-nitro-lH-pyrazole and (R)-l-(2-(difluoromethoxy)prop}7l)-3-methyl-4-nitro-lH-pyrazole as a yellow oil. LCMS: RT 0.873 min, m/z = 236.1 [M + H]+.

The chemical industry reduces the impact on the environment during synthesis 3-Methyl-4-nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Related Products of 3469-69-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3469-69-0 name is 4-Iodopyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[00235] 4-lodopyrazole (10.0 g, 51 .55 mmol) was dissolved in 1 ,4-dioxane (40 mL) and to this was added potassium carbonate (7.12 g, 51 .55 mmol) followed by 4-methoxybenzyl chloride (6.99 mL, 51 .55 mmol) and the reaction was stirred at reflux overnight. Upon cooling, the reaction mixture was concentrated and the residue was partitioned between ethyl acetate and water. The organic phase was washed with brine, dried over sodium sulphate, filtered and evaporated to give a yellow oil. This was purified by column chromatography eluting with an ethyl acetate/hexane gradient, 0-30% ethyl acetate. Fractions containing product were combined and evaporated to give the title compound (9.20 g, 57%) as a straw coloured oil which crystallized on standing. 1 H NMR (400 MHz, DMSO-cf6) delta 7.98 (d, J= 0.7 Hz, 1 H), 7.52 (d, J= 0.7 Hz, 1 H), 7.28 – 7.17 (m, 2H), 6.98 – 6.85 (m, 2H), 5.24 (s, 2H), 3.73 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodopyrazole, and friends who are interested can also refer to it.

Synthetic Route of 89088-55-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89088-55-1, name is 5-Bromo-1-methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of tert-butyl ((1 r,4r)-4-(bi s(tert-butoxycarbonyl)amino)cyclohexyl)(8 – ethyl-6-(4,4, 5,5-tetramethyl- 1,3 ,2-dioxaborolan-2-yl)quinazolin-2-yl)carbamate (900 mg, 1.2 mmol), 5-bromo-i-methyl-1H-pyrazol-3-amine (227 mg, 1.2 mmol), K2C03 (536 mg, 3.9 mmol) and Pd(dppf)C12 (95 mg, 129.2 umol) in dioxane (4.0 mL) and H20 (400 uL) was degassed and purged with N2 for 3 times, and then the mixture was stirred at 90C for 12 h under N2 atmosphere. The reaction was concentrated to give a residue. The residue was purified by column chromatography (Si02, Petroleum ether / Ethyl acetate = 10/i to 0/i) to afford tert-butyl (6-(3 -amino-i-methyl-i H-pyrazol-5 -yl)-8 -ethylquinazolin-2-yl)(( 1 r,4r)-4-(bis(tert- butoxycarbonyl)amino)cyclohexyl)carbamate (590 mg, crude).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1-methyl-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.

Application of 3463-30-7, These common heterocyclic compound, 3463-30-7, name is 1-(4-Nitrophenyl)-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a typical reaction, 5.0 mg of Pd-gCN (5.0 wtpercent of Pd) catalyst was added to the solution of 1.0 mM of nitroarene in ethanol (2 mL)and 2 mM (1.2 equiv. 0.07 mL) of 60percent of hydrazine hydrate. The mixture was placed into a 10 mL round-bottom flask at the reflux temperature (70¡ã C) for the 4 h and then allowed to cool at room temperature. The resultant material was filtered and the filtrate was subjected to column chromatography over silica gel to obtain the corresponding products. For di-nitroarenes substrates 4.0 mM(2.4 equiv. 0.14 mL) of 60percent of hydrazine hydrate solution was used.

The synthetic route of 3463-30-7 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73387-46-9, name is 3-(4-Bromophenyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C9H7BrN2

To a heated (80 0C) solution of 3-(4-bromophenyl)-lH-pyrazole (1.0 g, 4.5 mmol) and trifluoroacetic acid (0.02 mL, 0.23 mmol) in toluene (5 mL) was added 3,4-dihydro- 2H-pyran (0.43 mL, 4.7 mol) over 1 hour. The reaction mixture was stirred for an additional hour and was then concentrated and dried to provide 3-(4-bromophenyl)-l-(tetrahydro-2H- pyran-2-yl)-lH-pyrazole (1.3 g, 94% yield). MS (EI) for Ci4H15BrN2O: 308 (MH+).

According to the analysis of related databases, 73387-46-9, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5744-56-9, name is 1,3-Dimethyl-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

The 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide was prepared from 3-nitrobenzoyl chloride using the following multiple step procedure: Step 1: 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide.; A dry 250 mL flask was charged with 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid (0.989 g, 7.057 mmol) and thionyl chloride (5 mL) and allowed to stir at 79 C. for 2 h. The thionyl chloride was then removed by concentration in vacuo. The crude acid chloride was cooled to room temperature, and then dissolved in THF (40 mL). 6-(3-Amino-benzoyl)-1,3-dihydro-indol-2-one (as prepared in Example 40, 1.26 g, 4.994 mmol) was added to the THF solution of the acid chloride, and the mixture was allowed to reflux for 4 h. The reaction mixture was then allowed to cool to room temperature. The room temperature reaction mixture was concentrated in vacuo. The solid residue was suspended in boiling EtOAc. The suspension was allowed to cool to room temperature before filtering to afford the 2,5-Dimethyl-2H-pyrazole-3-carboxylic acid [3-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide as a tan solid (1.4 g, 3.74 mmol, 75%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.