Related Products of 3469-69-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3469-69-0 name is 4-Iodopyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[00235] 4-lodopyrazole (10.0 g, 51 .55 mmol) was dissolved in 1 ,4-dioxane (40 mL) and to this was added potassium carbonate (7.12 g, 51 .55 mmol) followed by 4-methoxybenzyl chloride (6.99 mL, 51 .55 mmol) and the reaction was stirred at reflux overnight. Upon cooling, the reaction mixture was concentrated and the residue was partitioned between ethyl acetate and water. The organic phase was washed with brine, dried over sodium sulphate, filtered and evaporated to give a yellow oil. This was purified by column chromatography eluting with an ethyl acetate/hexane gradient, 0-30% ethyl acetate. Fractions containing product were combined and evaporated to give the title compound (9.20 g, 57%) as a straw coloured oil which crystallized on standing. 1 H NMR (400 MHz, DMSO-cf6) delta 7.98 (d, J= 0.7 Hz, 1 H), 7.52 (d, J= 0.7 Hz, 1 H), 7.28 – 7.17 (m, 2H), 6.98 – 6.85 (m, 2H), 5.24 (s, 2H), 3.73 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodopyrazole, and friends who are interested can also refer to it.