Electric Literature of 105434-90-0, The chemical industry reduces the impact on the environment during synthesis 105434-90-0, name is Ethyl 5-amino-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.
LAH (20 mg, 0.51 mmol) was added to an ice cooled solution of ethyl 5-amino-l-((2-(5-phenylisoxazole-3-carboxamido)ethyl)sulfonyl)-lH- pyrazole-3-carboxylate (100 mg, 0.2537 mmol) in THF (10 mL) and the reaction mixture was stirred for 1 h at the same temperature. Then the reaction mixture was quenched with saturated NH4C1 solution and filtered through celite pad. The filtrate was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford crude compound which was further purified by preparative HPLC to obtain N-(2-((5-amino-3-(hydroxymethyl)-lH-pyrazol-l- yl)sulfonyl)ethyl)-5-phenylisoxazole-3-carboxamide (23 mg, 7% over two steps). (0261) [00169] Appearance: white solid (0262) [00170] Analytical data: XH NMR (400 MHz, DMSO-d6): delta 8.89-8.87 (m, IH), 7.94-7.92 (m, 2H), 7.58-7.54 (m, 3H), 7.36 (s, IH), 6.07 (s, D20 exchangeable, 2H), 5.34 (s, IH), 5.16 (t, J=6.0 Hz, IH), 4.25 (d, J=6.0 Hz, 2H), 3.76 (t, J=6.6 Hz, 2H), 3.61-3.56 (m, 2H). (0263) [00171] LC-MS: [M+H]+=391.9 (0264) [00172] HPLC Purity: 98.50% at 254 nm and 98.37% at 220 nm.
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