Related Products of 5334-39-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.
To a mixture of 3-methyl-4-nitro-lH-pyrazole (5 g, 39.34 mmol) and (R)-2- methyloxirane (3.43 g, 59.01 mmol, 4.13 mL) in DMF (50 mL) was added Cs2C03 (19.23 g, 59.01 mmol) at 20 C. The mixture was heated to 80 C and stirred for 15 h then cooled to 20 C and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc = 10: 1 to 0: 1) to give the mixture of (R)-l-(5-methyl-4-nitro-lH-pyrazol-l -yl)propan-2-ol and (R)-l-(3-methyl-4-nitro-lH-pyrazol-l-yr)propan-2-ol as a yellow liquid. LCMS: RT 0.133 min, m/z = 186.1 [M+H]+ To a solution of the mixture (R)-l-(5- methyl-4-nitro-lH-pyrazol-l -yl)propan-2-ol and (R)-l -(3-methyl-4-nitro-lH-pyrazol-l-yl)propan-2-ol (3 g, 16.2 mmol) in CH3CN (150 mL) was added Cul (617 mg, 3.24 rnmol), then a solution of 2,2-difluoro- 2-fluorosulfonyl-acetic acid (4.33 g, 24.30 mmol, 2.5 mL) in CH3CN (150 mL) dropwise at 20 C over a period of 30 min under N2. The reaction mixture was wanned to 55 C and stirred for 2 h then cooled to 20 C and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc :=: 10: 1 to 0: 1) to give the mixture of (R)-l-(2-(difluoromethoxy)propyl)-5- methyl -4-nitro-lH-pyrazole and (R)-l-(2-(difluoromethoxy)prop}7l)-3-methyl-4-nitro-lH-pyrazole as a yellow oil. LCMS: RT 0.873 min, m/z = 236.1 [M + H]+.
The chemical industry reduces the impact on the environment during synthesis 3-Methyl-4-nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.