Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1780-72-9, name is 4-Bromo-5-methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., name: 4-Bromo-5-methyl-1H-pyrazol-3-amine
General procedure: The kinetics of reactions were followed by measuring the change in absorbance at suitable wavelengthsas a function of time. Working wavelengths were determined for each reaction system, recording thespectra of reaction mixture over wavelength range between 220 and 600 nm. Substitution reactionswere studied under pseudo-first-order conditions whereas the concentration of entering ligand wasalways in large excess (at least 10-fold). Reactions were initiated by mixing equal volumes (1.5 cm3) ofcomplex (2 × 10-4 M) and ligand (2 × 10-3; 4 × 10-3; 6 × 10-3; 8 × 10-3; 1 × 10-2 M) solutions in a quartzcuvette. The changes in absorbance versus time were fitted as a single-exponential function usingOrigin Pro 8. Values for the pseudo-first-order rate constants, kobsd, were calculated as the average valuefrom three to five independent kinetic runs. Experimental data are reported in tables S2-S13 (supplementarymaterial). The values of pseudo-first-order rate constants, kobsd, at 298 K were recalculatedby Guggenheim and Kezdy-Swinbourne methods (table 14S) [33, 34]. All reactions were studied atfour different temperatures (288, 298, 308, and 313 K). The activation parameters, DeltaH? and DeltaS?, werecalculated using the Eyring equation. Eyring plots for all studied systems are given in supplementarymaterial, figures 4S-15S.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kosovi?, Milica; Jovanovi?, Sne?ana; Bogdanovi?, Goran A.; Giester, Gerald; Ja?imovi?, ?eljko; Bugar?i?, ?ivadin D.; Petrovi?, Biljana; Journal of Coordination Chemistry; vol. 69; 19; (2016); p. 2819 – 2831;,
Pyrazole – Wikipedia,
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