Category: 14531-55-6

Reference of 14531-55-6, A common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, molecular formula is C5H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3,5-dimethyl-4-nitro-1H-pyrazole (199.5 mg, 1.4 mmol) and potassium t-butanoate (173.8 mg, 1.5 mmol) weredissolved in DMSO (1 mL). After 15 minutes, 4-fluorobenzonitrile (182.0 mg, 1.5 mmol) was added, and the reactionmixture was heated to 120 C and left stirring for 5 h. The reaction mixture was then diluted with water and DCM, thephases were separated and the aqueous phase was extracted 3 times with DCM. The reunited organic phase was driedover MgSO4, filtered and concentrated. The crude was purified by column chromatography (25% EtOAc in PE) yielding263 mg (77%) of the title compound.

The synthetic route of 14531-55-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Deutsches Krebsforschungszentrum; MILLER, Aubry; SCHUeLER, Peter; DE VITA, Elena; (147 pag.)EP3305781; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H7N3O2

To a suspension of 3,5-dimethyl-4-nitro-1H-pyrazole (201 mg, 1.4 mmol) and K2CO3 (216 mg, 1.6 mmol) indry DMF (1 mL), iodomethane (93 mL, 1.5 mmol) was added at room temperature. After 5 h, the reaction was heated to 40 C and additional iodomethane (90 mL) and K2CO3 (200 mg) was added. After 1.5 h, the reaction was quenchedwith Et3N (150 mL), diluted with H2O (15 mL) and EtOAc (15 mL). The two layers were separated and the aqueous layerwas extracted with EtOAc (2 x 10 mL). The combined organics were dried (MgSO4), filtered, and concentrated in vacuo.Purification by column chromatography (30% EtOAc in PE) yielded 206 mg (93%) of the title compound

The synthetic route of 3,5-Dimethyl-4-nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14531-55-6 as follows. Safety of 3,5-Dimethyl-4-nitro-1H-pyrazole

To a solution of 3,5-dimethyl-4-nitro-1H-pyrazole (2.5 g, 17.7 mmol) and caesium carbonate (6.06 g, 18.6 mmol) in DMF (50 mL) was added 2-bromoethyl methyl ether (2.59 g, 1.75 mL, 18.6 mmol). The mixture was heated at 100 C for 3.5 h. After cooling to room temperature, the mixture was poured into water and extracted with ethyl acetate (3x 50 mL).The combined organic layers were washed with brine (50 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (EtOAc/heptanes = 1/4 v/v%) to afford 1- (2-methoxyethyl) -3,5 -dimethyl-4- nitro-pyrazole (2.66 g, 75.4%) as a white crystalline solid.

According to the analysis of related databases, 14531-55-6, the application of this compound in the production field has become more and more popular.

Related Products of 14531-55-6, A common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, molecular formula is C5H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Lambda -(1 -(2-Hydroxyethyl)-3,5-dimethyl-1 H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamideStep 1 : To a solution of 3,5-dimethyl-4-nitro-1 H-pyrazole (500 mg, 3.52 mmol) in MeCN (5 ml_), Cs2C03 (1.26 g, 3.87 mmol) and 2-bromoethanol (0.3 ml_, 4.21 mmol) was added. The resulting mixture was refluxed (90 C) for 3 h, then the reaction mixture was allowed to reach rt. The mixture was diluted with DCM, filtered, the filter cake rinsed with DCM and the filtrate concentrated in vacuo. The residue was partitionned between water and EtOAc, the org. layer was separated and the aq. layer was extracted with EtOAc (1x). The combined org. layers were washed with brine, dried (MgS04), filtered and concentrated in vacuo to yield 2- (3,5-dimethyl-4-nitro-1 H-pyrazol-1-yl)ethanol as a white solid. LC-MS conditions A: tR = 0.53 min, [M+H]+= 186.39

The synthetic route of 14531-55-6 has been constantly updated, and we look forward to future research findings.

Application of 14531-55-6,Some common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, molecular formula is C5H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3,5-dimethyl-4-nitro-1 H-pyrazole (0.5 g, 3.54 mmol) in acetonitrile (10 mL), K2C03 (1.4 g, 10.62 mmol) was added and the mixture was stirred at room temperature for 30 minutes. Then tert-butyl-(2-chloroethoxy)dimethylsilane (1.2 g, 5.31 mmol) was added dropwise. The mixture was heated at reflux overnight. To the cooled reaction mixture H20 (20 ml) was added and the product was extracted with ethyl acetate (3 x 50 ml), the organic layers were combined, dried over Na2S04 and evaporated under reduced pressure. The residue was purified on HP-Sil SNAP cartridges using a Biotage Isolera One purification system employing an EtOAc/n-heptane gradient (5/95 -> 40/60) to afford the title compound which was used in the next step without further purification (0.72 g, 68 %). 1H-NMR (400 MHz, DMSO-d6) delta = 4.20 (t, 2H), 3.90 (t, 2H), 2.60 (s, 3H), 2.41 (s, 3H), 0.78 (s, 9H), -0.09 (s, 6H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dimethyl-4-nitro-1H-pyrazole, its application will become more common.

These common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3,5-Dimethyl-4-nitro-1H-pyrazole

3,5-dimethyl-4-nitro-1 H-pyrazole (201 mg, 1.4 mmol), K2CO3 (411 mg, 3.0 mmol), CuI (13.6 mg, 0.07 mmol),trans-N,N-dimethylcyclohexyldiamine (44.8 mL, 0.3 mmol) were 3-iodotoluene (528 mL, 4.1 mmol) were combined in amicrowave vial and irradiated for 4 h to 195 C in the microwave. The reaction mixture was filtered through celite, washedwith EtOAc, concentrated in vacuo and was purified by column chromatography (10% EtOAc in PE) to yield 233 mg(71%) of the title compound.

The synthetic route of 3,5-Dimethyl-4-nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Application of 14531-55-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A solution of L1 (0.21 g, 1.5 mmol) in methanol (20 mL) wasadded drop wise, under continuous stirring, to a solution of coppernitrate trihydrate Cu(NO3)2¡¤3H2O (0.348 g, 1.5 mmol) in methanol(5 mL). The resulting blue solution was stirred at room temperature.After 30 min, a solution of 1,10-phenanthroline (0.297 g,1.5 mmol) was added to the mixture reaction, sensing a colourenhancement. The solution was stirred for more 30 min at roomtemperature. After filtration, the solution rests at room temperature.Suitable blue crystals for (1), appear in few days, and wereused for all measurements. Yield (based on Cu2+): 76%. ElementalAnal. Calc. for C22H24CuN10O11 (Mr = 668.04): C, 39.55; H, 3.62; N,20.97. Found: C, 39.43; H, 6.43; N, 21.02%. IR (KBr, sigma/cm-1): 3207(m), 3137(m), 3067 (m), 2997(m), 2897 (m), 1585 (s), 1509 (s),1392 (vs), 1360 (vs), 1170 (s), 1142 (m) 1114 (m), 1029 (w), 849(s), 725 (s), 674 (w), 569 (w), 428 (w).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 14531-55-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

DIAD (837muIota_, 4.25mmol) was added to a solution of 3-methyl-4-nit.ro- 1 H-pyrazole (500mg, 3.54mmol), /V-methyl-4-piperidinol (408mg, 3.54mmol) and triphenylphosphine (860mg, 4.25mmol) in THF (25ml_). The reaction mixture was stirred at rt for 5 days. The mixture was cone, in vacuo before purification by flash chromatography on silica, washing with DCM, then 30%, 70%, 100% EtOAc/DCM mixtures. The product was eluted with 5%, 10% then 20% MeOH/DCM to give the title compound as an off-white crystalline solid (289mg, 34%). LCMS (Method 1 ) Rt 2.721 min, ESIMS m/z [M+H]+ 239.3.

The synthetic route of 3,5-Dimethyl-4-nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H7N3O2

1000941 To a stirred solution of 3,5-dimethyl-4-nitro-1H-pyrazole 27 (2.0 g, 1.41 mmol) in THF (20 mL), sodium hydride (0.4 g, 60% in mineral oil, 2.82 mmol) was charged at 0C. After stirring for 10 minutes, iodomethane (0.87 mE, 1.41 mmol) was charged and stirred at room temperature for 2 h. The reaction mixture was diluted with water (50 mL) and ethyl acetate (50 mL). The organic layer was dried (Na2SO4), filtered and evaporated to obtain l,3,5-trimethyl-4-nitro-1H-pyrazole 29 (2.1 g, 95% yield). ?HNMR (400 MHz, DMSO-d6): oe 3.77 (s, 3H), 2.59 (s, 311), 2.56 (s, 311).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 14531-55-6.

Synthetic Route of 14531-55-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A solution of 3,5-dimethyl-4-nitro-1H-pyrazole (5.00 g, 35.4 mmol) and (4-cyanophenyl)boronic acid (5.21 g, 35.4 mmol) in dichloromethane (50 ml, 780 mmol) was treated with anhydrous cupric acetate (9.65 g, 53.1 mmol), pyridine (29 ml, 350 mmol) and molecular sieves (7.93 g). The mixture was stirred under an argon atmosphere at ambient temperature for 2 days. The mixture was filtered over a pad of kieselgur, the remainng filter cake was washed with dichloromethane. The filtrate was washed with water, dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by falsh-chromatography on silics gel (dichloromethane/ethyl acetate 40: 1, column: SNAP Ultra 100 g) to yield 2.60 g (30%) of the desired product. LC-MS (method 9): Rt = 0.88 min; MS (ESIpos): m/z = 243 [M+H]+1H-NMR (400 MHz, dimethylsulfoxide-d6) delta [ppm]: 2.625 (16.00), 7.797 (0.49), 7.802 (3.48), 7.807 (1.24), 7.819 (1.33), 7.824 (4.13), 7.829 (0.63), 8.076 (0.59), 8.081 (3.97), 8.086 (1.28), 8.098 (1.17), 8.103 (3.35), 8.109 (0.49).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.