Reference of 14531-55-6, A common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, molecular formula is C5H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3,5-dimethyl-4-nitro-1H-pyrazole (199.5 mg, 1.4 mmol) and potassium t-butanoate (173.8 mg, 1.5 mmol) weredissolved in DMSO (1 mL). After 15 minutes, 4-fluorobenzonitrile (182.0 mg, 1.5 mmol) was added, and the reactionmixture was heated to 120 C and left stirring for 5 h. The reaction mixture was then diluted with water and DCM, thephases were separated and the aqueous phase was extracted 3 times with DCM. The reunited organic phase was driedover MgSO4, filtered and concentrated. The crude was purified by column chromatography (25% EtOAc in PE) yielding263 mg (77%) of the title compound.
The synthetic route of 14531-55-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Deutsches Krebsforschungszentrum; MILLER, Aubry; SCHUeLER, Peter; DE VITA, Elena; (147 pag.)EP3305781; (2018); A1;,
Pyrazole – Wikipedia,
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