These common heterocyclic compound, 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H7N3O2
To a suspension of 3,5-dimethyl-4-nitro-1H-pyrazole (201 mg, 1.4 mmol) and K2CO3 (216 mg, 1.6 mmol) indry DMF (1 mL), iodomethane (93 mL, 1.5 mmol) was added at room temperature. After 5 h, the reaction was heated to 40 C and additional iodomethane (90 mL) and K2CO3 (200 mg) was added. After 1.5 h, the reaction was quenchedwith Et3N (150 mL), diluted with H2O (15 mL) and EtOAc (15 mL). The two layers were separated and the aqueous layerwas extracted with EtOAc (2 x 10 mL). The combined organics were dried (MgSO4), filtered, and concentrated in vacuo.Purification by column chromatography (30% EtOAc in PE) yielded 206 mg (93%) of the title compound
The synthetic route of 3,5-Dimethyl-4-nitro-1H-pyrazole has been constantly updated, and we look forward to future research findings.